Journal of Medical Pharmaceutical and Allied Sciences

  People with chronic diseases are at higher risk of a pandemic threat because COVID-19 can affect their clinical outcomes, including mental illness and cardiovascular disease. COVID-19 has reduced access to healthcare facilities and physicians for patients with chronic diseases who require regular visits, follow-ups, testing and prescription refills. The aim of this study is to analyse the effectiveness of hypertension therapy based on the patient's blood pressure level at each visit. This is a descriptive-analytical study that uses a cross-sectional approach and retrospective data. Data collection started in April and ended in October 2021. Data were collected from the medical records of the Oesapa Health Centre in Kupang City to conduct the research. 165 respondents participated in the study. The results of the study of patients with hypertension in the area of research data showed non-compliance in carrying out health control or treatment, namely 229 respondents (83.27%), then ...

  The list of most useful Indian traditional medicinal plants includes Nyctanthes arbor-tristis, popularly known as Night jasmine. It is widely distributed in the sub-Himalayan regions and south of the Godavari.Each component of the plant has some significant medicinal value and can therefore be used for profit. The present review article illustrates an updated account of the analysis of different pharmacophores from the plant, N. arbor-tristis, and their potential biomedical applications. The significant pharmacological activities of different parts of the plant such as seeds, leaves, flowers, bark, and fruits, have been studied. Numerous phytochemicals contained in this plant including glycosides, flavonoids, essential oils, oleanic acid, carotene, tannic acid, lupeol, friedelin, benzoic acid, and glucose, have been studied and tested for their potential anti-inflammatory, hepatoprotective, anti-viral, anti-leishmaniasis, anti-pyretic, anti-fungal, anti-malarial, and anti-histami...

  The purpose of this article is to synthesize some novel quinoline-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help of elemental analysis, IR, NMR, and mass spectral data, the synthesized derivatives were identified. Derivatives' antibacterial activity was determined using the cup and plate diffusion method. At doses of 50 μg/ml and 100 μg/ml, the substance demonstrated substantial antibacterial potential against the tested strains. To predict the pharmacokinetic properties (ADME) of these derivatives, in-silico investigations were also carried out. For the current study, the in silico Swiss ADME-assisted results were shown to be suitable for the derivation and synthesis of efficient antibacterial drugs. https://jmpas.com/abstract/1187

  An injury to the cartilage is a physical disruption of the cartilage's architecture, resulting in fluid loss and pain to the individual. The earliest possible diagnosis of various cartilage defect complications is vital to facilitate healing. Moreover, to fasten the healing process of the cartilage defect, tissue-engineered materials should have several key characteristics, including ideal porosity, and minimal cytotoxicity. The primary characteristic of polymeric hydrogel scaffolds is that they offer a moist environment that accelerates the cartilage repair and good biocompatibility. Most often, biocompatible polymers and incorporated agents (such as stem cells, drug molecules, and bioactive agents) exhibit synergistic effects, resulting in very high therapeutic indexes. This review highlights the phases of cartilage repair, types of natural and synthetic Polymer loaded hydrogels used in Cartilage tissue regeneration, and the importance of the stem cells loaded hydrogel in carti...

  Cadmium Sulfide nanoparticles (CdS NPs) were synthesised and their characteristics were evaluated using XRD (X-ray diffraction), FTIR (Fourier transform infrared), FESEM (Field emission scanning electron microscopy), EDAX (Energy Dispersive X-ray Analysis), and UV-Vis (Ultraviolet-visible). Further, the impacts of CdS NPs on the growth, pigment content and antioxidative defence system of Pistia stratiotes were studied. The exposure of CdS NPs to Pistia stratiotes caused the negative repercussions, which were tested using a variety of biological tests. The findings demonstrated that CdS NPs were hazardous to the Pistia plant at high concentrations, while they were easy to grow at lower concentrations up to 30 ml/l. Both growth and colour characteristics declined at 40 mg/l concentration of CdS NPs. Antioxidant enzymes' activity like superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT) also decreased at 40 ml/l on 60 days. The Protein and photosynthetic pigment...

  Coffee contains more than a thousand molecules, including phenolic compounds, vitamins, minerals and alkaloids. Caffeine, cafestol, kahweol and chlorogenic acid are related to lipid metabolism and can affect serum lipid profiles. Clinical studies have reported the effects of caffeine on cardiac arrhythmias, liver function, serum cholesterol and blood pressure. Malondialdehyde (MDA) in the human body is a by-product of free radicals (oxidative stress), which can indicate whether oxidative stress is detrimental. This study aims to analyse the effect of strong coffee on MDA levels in healthy adults. This study used a quasi-experimental design with a nonequivalent control group. This design was divided into two groups: the treatment group and the control group. The treatment group was given the treatment of drinking coffee and not eating foods that can raise cholesterol. In the control group, they did not drink coffee or eat foods that could cause increased malondialdehyde levels. Th...

  The use of herbal medicinal plants has been found widely in the community as traditional medicine. One example is the Cinnamon plant (Cinnamomum burmannii) which contains cinnamaldehyde as the main compound. Cinnamaldehyde is known to have a major role in lowering blood sugar levels. Determination of the content of bioactive compounds in extracts is beneficial in determining the safety, quality, and efficacy of the plants used. So it is necessary to do a quantitative analysis test on the cinnamaldehyde compound in cinnamon plants by determining its levels using the HPLC method. It is necessary to validate the method analysis based on parameters including selectivity, linearity, accuracy, precision, detection limit, and quantitation limit. The mobile phases in this method were acetonitrile mobile and 0.04�etic acid solution (60:40), The stationary phase was octadecylsilane (C-18), The flow rate was adjusted at 1.0 mL/min with column temperature adjusted at 29°C, injection volume 2...

  In the current healthcare environment, nosocomial infection is regarded as one of the most life-threatening infections. Hospitalized patients are exposed to contaminants from a range of sources, including medical staff and other sick people. Bacteria associated biofilm infection spread in central line associated blood infections, catheter-associated urinary tract infection, surgical site infection and ventilator-associated respiratory system. According to WHO reports, nearly 15% of all hospitalized patients suffer from this infection. Patients with indwelling urinary catheters have a higher risk of developing urinary tract infections because biofilm formation bacteria can enter the urinary system directly. Metal based nanoparticles is the most advantageous in prevention of biofilm disruption rather than conventional antibiotics. The creation of engineering tailored nanoparticles may signal a new era in the efficient treatment of nosocomial infection caused by the growth of biofil...

  Vitamin D is a fat-soluble compound with antioxidant properties that are important for maintaining the body's mineral balance. Vitamin D can be obtained from exogenous sources (food) or endogenously synthesised by the skin through exposure to the sun's ultraviolet rays. Although it is a vitamin, it is also considered a hormone because it is activated by chemical reactions in the body. The aim of this study was to analyse the effect of walking on vitamin D levels and sleep quality. The research used a quasi-experimental method with a randomised pre- and post-test-controlled group design. In this study, two groups were randomised, the intervention group and the control group. Both groups were pre-tested and then post-tested to find out the difference in average vitamin D levels and sleep quality. Gender, age, BMI, systolic and diastolic blood pressure were not found to be confounding variables. There were no significant changes in the pre- and post-sleep quality scores of the c...

  Caffeine intake reduces sleep quality and melatonin secretion, the hormone responsible for regulating sleep. Chewing gum increases alertness and improves concentration. This study aims to investigate the impact of coffee consumption and gum chewing on serum melatonin levels in a study population of 40 Jordanian subjects (mean age, 21.15±3.21 years), including 23 males and 17 females. A total of 40 participants volunteered and met the inclusion criteria and were divided into four groups; a control group did not consume espresso coffee and chewed gum during the study period, a second group consumed two cups of espresso coffee (240 ml), and the third group chewed Gum constantly throughout the procedure; finally, the fourth group consumed two cups of espresso coffee and chewed Gum constantly throughout the process. Melatonin serum levels were measured one hour before and one hour after the completion of the study; the duration was five hours. The findings revealed that the coffee plu...

  In 2023, the field of pharmaceuticals witnessed the approval of several novel drugs by the United States Food and Drug Administration (USFDA). These drugs represent significant advancements in the treatment of various medical conditions and have undergone rigorous evaluation to ensure their safety and efficacy. To support their development and subsequent quality control, a variety of analytical methods have been employed. This review highlights the analytical methods employed for the evaluation and quality control of FDA approved drugs. These methods encompass a range of techniques that enable the characterization, quantification, and quality assessment of pharmaceutical compounds. Commonly employed analytical techniques include chromatographic methods such as high-performance liquid chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), Ultra-Performance Liquid Chromatography (UPLC), Ultra-high-performance liquid chromatography (UHPLC), Ultra- performance liquid...

  Antibiotics are antimicrobial drugs that kill germs and are crucial in the fight against bacterial infections. These medications are widely used in the prevention and treatment of diseases because they may either kill or stop bacteria from growing. Microbial resistance refers to bacteria's capacity to survive antibiotics' bacteriostatic or cytotoxic effects. The samples for this study are taken from Song and Suswa River, Dehradun, Uttarakhand. The main aim of this study is to isolate several species to find out if them are resistant to antibiotics. The methodologies used in this research are isolation and haracterization of bacteria, antibiotics sensitivity test. There were 17 types of antibiotics were used i.e. Azithromycin, Amikacin, Cefaclor, Cefepime, Cefoxitin, Doxycycline Hydrochloride,Erythromycin, Gentamycin, Kanamycin, Levofloxacin, Mecillinam, Mezolocilline, Penicillin G, Vancomycin, Tetracycline, Ticarcilline, Nitrofurantoin. The result was that species like Salmon...