Journal of Medical Pharmaceutical and Allied Sciences

 In conclusion, increasing the centrifugation time to 5 hours had the highest impact on SC-514 loaded PLGA particle size reduction. SC-514 loaded PLGA particles potentially possess high drug efficiency and effective drug release pharmacokinetics, if the particle size is appropriate for the application. SEM and TEM studies suggested that the morphology and size of SC-514 loaded PLGA particles formed in this study was appropriate to keep the SC-514 drug potent until the SC-514 drug is released. Thus, PLGA particles loaded with SC-514 drug has the potential to solve the problem of low solubility or low bioavailability of SC-514 drug during prostate cancer treatments. For complete details visit :  Toluleke Oloruntobi Famuyiwa, Joubin Jebelli , Zoey Bowers , Austin Bentley, Davian Caraballo, Paulynice Subtil , James Kwasi Kumi Diaka, Waseem Asghar . A NEW APPROACH FOR PREPARING SC-514 LOADED PLGA PARTICLES BY SINGLE EMULSION METHOD, Journal of Medical Pharmaceutical and Allied Scie...

 The proposed method was checked for the performance characteristics and has also been validated and the method can easily and conveniently be adopted for the estimation of Prasugrel Hydrochloride. For complete details visit : Dr. Juluri Krishna Dutta Tejaswi. ESTIMATION OF PRASUGREL HYDROCHLORIDE IN BULK DOSAGE FORM BY UV, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 910. March-April 2020, P-2449-2454. 

 The HPTLC technique is a very scientific method for the quantification of individual ingredients used in Polyherbal formulations. The HPTLC fingerprinting can be used as a reliable method for the identification of individual crude drugs in a formulation. Having established official standards for the crude drugs and Ayurvedic formulations, it now becomes possible to fix a range for all the ingredients present in a formulation. The HPTLC method described for Patoladi Ghrita can be extended to other type of formulations with suitable modifications. For example, in the case of liquid oral preparations, a Chloroform extract may be prepared instead of the methanol preparation. For complete details visit :  P. N. Presannakumaran, P. Jayasekhar. HPTLC METHOD FOR THE ESTIMATION OF COLEUS VETTIVEROIDES IN PATOLADI GHRITA- AN AYURVEDIC POLYHERBAL FORMULATION, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 909. March-April 2020, 2437-2448.

 On the basis of results obtained it can be concluded that 100% alcohol crude extract, partially purified petroleum ether fraction of Eucalyptus globulus leaf were showed maximum inhibition against Alternaria solani as compare to standard fungicides. This will be used to develop an eco-friendly natural fungicide which will not leave any toxic substance in the environment. For complete details visit : Mehta Surbhi , Sharma Kanika . PREVENTION OF FUNGI BY NATURAL ANTIMICROBIAL AGENTS, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 907. March-April 2020, 2428-2436.

 Disintegrants, a significant excipient of the tablet detailing, are constantly added to tablet to prompt separation of tablet when it interacts with watery liquid and this procedure of integration of constituent particles before the medication disintegration happens, is known as deterioration process and excipients which instigate this procedure are known as disintegrants. The targets behind option of disintegrants are to expand surface territory of the tablet sections and to defeat firm powers that keep particles together in a tablet. Disintegrants grow and disintegrate when wet making the tablet break separated in the stomach related,discharging the dynamic elements for assimilation. They guarantee that when the tablet is in contact with water, it quickly separates into little pieces. Superdisintegrants assumes a basic job in the plan of mouth dissolving tablets. These operators help and encourage tablets to scatter into its littler sections. For complete details visit :  K...

 COVID-19 is a pandemic which is triggered by corona virus. It mainly effects the respiratory system as of now there is no specific treatment for the disease. To cure the infection in this limited period of time, the repurposing of available drugs is best possible way. In this we concluded some of the drugs which can effectively work in the cure of COVID-19. For complete details visit :  Ravella Sai Yamini, Ravella Sai Bhargavi, Kotha Bhuvaneswari . DRUG REPOSITIONING IN THE TREATMENT OF COVID-19,Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 903. March-April 2020, 2412-2417. 

 Several techniques have been used for the collection of gingival crevicular fluid but in case of GCF collection methods, absorbent filter paper strip method are easiest and more precise method. The most common technique of collection was absorbent filter paper strip, which could be extra crevicular or intra crevicular. The best procedure of assortment; is intra crevicular system. It's viewed as the most ideal route for observing the progression of GCF as it gives tests to quantitative investigation of the GCF parts. For complete details visit :  Gajbhiye Pranali, Gholse Yogesh, Kasliwal Rahul, Thakre Anup. A COMPREHENSIVE UPDATED REVIEW ON GINGIVAL CREVICULAR FLUID: CHARACTERISTICS, COLLECTION AND ESTIMATION, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 901. March-April 2020, 2405-241.

 In conclusion, radiosurgery treatment planning for brain lymphomas may be improved by incorporation of MRI into the target definition process despite the need for further supporting evidence. For complete details visit :  Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Murat Beyzadeoglu. RADIOSURGERY TREATMENT VOLUME DETERMINATION FOR BRAIN LYMPHOMAS WITH AND WITHOUT INCORPORATION OF MULTIMODALITY IMAGING, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 893. March-April 2020, 2398-2404.

 G. cambogia fruit typically has high content of the organic acid, HCA as active ingredient. Several other constituents have been isolated from various plant parts having various therapeutic activities such as appetite-suppressant, anti-obesity and hyperlipidaemic activity. G. indica and G. cambogia exerted anticancer potential. The research undergoing at present is potentially very useful which calls out a need for careful planning and application of these therapeutic mechanism. However, detailed mechanistic studies are needed for potential beneficial effects of this fruit rind which having potential in human health and diseases. For complete details visit :  Priya Hargunani, Sarita Sharma, Aruna Pai, Bhagyashree Patil, Dr. Ashish Jain. GARCINIA CAMBOGIA: AN ANCIENT FRUIT RIND WITH RECENTLY DISCOVERED THERAPEUTIC ACTIVITY, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 892. March-April 2020, 2391-2397.

 Oxidative stress and low serum paraoxonase activity are associated with cardiovascular diseases in subjects of Bangladeshi origin. Paraoxonase activity may serve as a new prognostic biomarker for patients with cardiovascular diseases, and a high level of paraoxonase activity may serve as protective. For complete details visit :  Md Amir Hossain, Israth Jahan Tuhin , Md. Mahfuzur Rahman , Muhammad Saiedullah2. LOSS OF PROTECTIVE FUNCTION OF PARAOXONASE ASSOCIATED WITH CARDIOVASCULAR DISEASES IN BANGLADESHI ORIGIN, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 1, 891. March-April 2020, 2381-2390.

 Wernicke Encephalopathy is a deadly illness mostly seen in alcoholics as a consequence of deficiency in thiamine intake, it primarily targets the nervous system. This article reports an unusual case of Non-Alcoholic Wernicke Encephalopathy in a 28 years old female patient, with 17 weeks of gestation, complaints of severe hyperemesis gravidum. Patient presented with SOB, Nystagmus, Opthalmoplegia and altered speech since 2 weeks. MRI Brain has shown hyperintense signals on T2W FLAIR in bilateral thalami, periaqueductal grey matter and mammillary bodies. The case was managed with 500mg Thiamine given twice daily and other supplementary treatment, patient had underwent an Intrauterine fetal demise followed by cardiac arrest. For complete details visit :  Bulla Sri Vidya1, Shaik Ameena , Nandyala Bhargavi Reddy , Ramavathu Vijaya Shree, NON-ALCOHOLIC WERNICKE ENCEPHALOPATHY COMPLICATING WITH HYPEREMESIS GRAVIDUM, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 2, 947...

 The study concluded that greater part of the study participants had self-medication (84.21%), the study states that more than 10% among elderly practiced selfmedication. The study showed females practiced selfmedication more than males. Their common reason were for practice were found to be previous experience, knowledge in relation to the drug, the study found that the fever, headache, infection. Were the main ailments for the participants that took to self-medication the most recurrently used class of drugs were analgesics (25.26%), antipyretics (19.47%), antibacterial (13.68%). The monthly income & knowledge about selfmedication drugs were both associated with SMP (selfmedication practice). For complete details visit :  Rowinea Fernandez, Dr.Sushma Muchukota, Priyanka Dey, Karishma Praveen, Alkayum Ahmed, Rashi L, Bhoomika, Dr. Rinkumathappan . IMPACT OF CLINICAL PHARMACIST TO IDENTIFY RISK FACTORS OF SELFMEDICATION PRACTICES AMONG ELDERLY IN BANGALORE- A SURVEY , Jour...

 Conventional chemotherapy kills not only the cancerous cells but also the healthy ones, which results in very strong side-effects. This significantly hampers the maximum administration of chemotherapeutic drugs. Moreover, short half-life and rapid plasma clearance requires the administration of a high amount of active drug which is costly and often leads to undesirable toxicity effect. Hence novel drug delivery methodologies are developed and employed for the effective treatment of various kinds of diseases. These methods decrease the dose frequency (through controlled and sustained drug delivery) and improve patient compliance. For complete details visit :  Anita Sharma, Sameer PMD. A COMPREHENSIVE REVIEW ON POLYMERIC NANO PARTICLES ,Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 2, 919. May-June 2020, P-2492-2501.

 The potential of fenugreek gum as a film-coating agent or polymer was investigated, with paracetamol tablets as model drug. The tablets were evaluated for diverse parameters such as uniformity of weight, friability, disintegration time, and dissolution profiles. Fenugreek seed gum can be used for development of visual qualities of dosage forms, masking disagreeable taste or odor, easing digestion, improving stability, and modifying the drug release characteristics of the drug. For complete details visit :  Ajay Kumar Shukla, Ajay Yadav, Ravi Kant Vishwakarma, Santosh Kumar Mishra. APPLICATIONS, ISOLATION AND CHARACTERIZATION OF FENUGREEK SEED GUM AS PHARMACEUTICAL EXCIPIENT, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 2, 920. May-June 2020, P-2484-2491.

 The End TB strategy milestones for 2020 and 2025 within the context of progress towards universal health coverage (UHC), can only achieved if TB diagnosis, treatment and prevention services provided, and if there is multisectoral action to address the broader determinants that influence TB epidemic and their socioeconomic impact. The vision and meaning of UHC that everyone can obtain the health services whenever they need without suffering financial hardship. The two indicators to monitor are a UHC service coverage index (SCI), and the percentage of the population experiencing household expenditures on health care that are large in relation to household expenditures or income that is the target of SDG 3.8 is to achieve UHC by 2030. Without the intensified research and development the SDG and End TB strategy targets set for 2030 cannot be achieved. The annual decline in the global TB incidence rate can be accelerated to an average of 17% per year, so those technological breakthroug...

 In light of trial considers, it was inferred that all the promoted toothpaste assessed and contrasted and the standard by Bureau of Indian Standards. This preliminary in vitro study showed that each of the six showcased toothpaste was similarly viable as far as all assessment properties. Consequently, by the proof of in vitro considers it was reasoned that the different parameters were assessed and thought about in the research center and was seen as a decent quality and among this closeup found to be better quality. For complete details visit :  Charde kirti, Upadhye Kanchan, Kawade Dinesh, Gholse Yogesh, Gajbhiye Pranali, Chaple Dinesh . COMPARISON OF EVALUATION PARAMETERS OF DIFFERENT BRANDS OF MARKETED TOOTHPASTE, Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 2, 916. May-June 2020, P-2472-2475. 

 Rural residents and communities lack easy access to healthcare services often due to geographical and demographic factors. Telepharmacy holds a significant role as a technology to improve access to pharmaceutical care for people living in rural and remote communities. It is an integral part of modern pharmacy practice that has the potential to provide quality pharmaceutical services, such as medication management, dispensing, patient counseling, and drug information as clinical benefits of tele-pharmacy. Likewise, the case study Express ECG helps the cardiac patient by providing the expert view with a quick and quality response. Apollo hospitals are performing many good works in reaching out to rural areas. It provides many services in a way to show their corporate social responsibilities. But, in medical treatment, the human interaction is less between medical professionals and patients, which may lead to an increased risk of error in medical services due to the registered profes...

 Intranasal drug delivery delivery system having a numerous advantages over the other routes of drug administration. Intranasal route provides a huge surface area, non- invasive, permeable endothelial membrane, high supply of blood flow, bypassing the hepatic metabolism and more accessibility. In the upcoming years, various approaches are made to prevail over the limitation of this drug delivery system. This drug delivery system having a novel approach to deliver the drug to the affected site of a brain which is hardly possible by other routes. Nasal formulations are beneficial and show efficacious results in case of asthma patients and patients having respiratory tract infections. It can be used for all kind of patients. This drug delivery received an excellent deal of attention for its convenient, promising, and reliable way of systemic administration for drugs, chiefly for those drugs which are ineffective orally and administered by injections. Hence, this delivery system must g...

 A new, simple, sensitive, and economical UV spectrophotometric method was developed for the simultaneous estimation of SAXA and DAPA in their tablet formulation. Validation of developed methods was performed according to ICH guidelines. The standard deviation, % RSD for the methods are low, reflecting a high degree of precision of the methods. The results of the recovery studies performed show the high degree of accuracy of the proposed methods. Vierordt’s method has the advantage of being simple, economic, rapid, and subsequently not required sophisticated technique, instrument, and costly solvents. Thus, the proposed methods can be successfully applied for the determination and dissolution testing of SAXA and DAPA in a commercial formulation (Qtern). For complete details visit :  Patel Aneesh Kumar, Dr. Omray Lavakesh, Soni Pushpendra. SPECTOPHOTOMETRIC METHOD DEVELOPMENT FOR THE ESTIMATION OF SAXAGLIPTIN AND DAPAGLIFLOZIN IN BULK AND FORMULATION,Journal of Medical Pharmace...

 In spite of the fact that the existing literature underpins the management of symptoms of manifestation of novel COVID-19 using turmeric is a broadly used in Ayurvedic, home remedies having antiseptic, antiviral, immunity booster potential, one of the significant concerns with developing Curcumin for clinical adequacy in novel methodologies but lack of standard formulations limits its use. This is the need of time to begin with translational research to give scientific proof the efficacy and build up standard formulations of turmeric in the management and treatment of high infections and deadly viral infections. For complete details visit :  Anil Kumar V. , Kamini Sethy , Dr. Himasree P.  . POSSIBLE CHARACTER OF CLASSICAL THERAPEUTIC RHIZOME OF TURMERIC FOR THE PREVENTION AND THE EXECUTIVES OF NOVEL CORONA VIRUS ,Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 3, 948. July 2020, P-2527-2535.

 The suitable chromatographic methods (RP-HPLC, HPTLC) were developed and validated for estimating a simple, economic, selective, and precise. HPLC method for stability indicating approach has been validated and developed for routine or specific analysis of acetazolamide tablets and its related compounds. Reversed phase chromatography was performed on a C-18 column with Acetonitrile: Phosphate Buffer in mobile phase with flow rate 1.0 ml/minute, spectra recording was performed on wavelength 265nm, occur adequate peak response and height at approximately 7.8 minutes retention time. The % RSD of peak area response of acetazolamide in LOQ level concentrated shown less than 5%. The chromatographic method was validated in many parameters such as specificity, accuracy, precision, robustness, reproducibility according to ICH guidelines. Statistically found that method was qualify with all validation parameters on acetazolamide tablets. This method was suitable for routine analysis be...

  Ocimum tenuiflorum Linn (Tulsi) is an aromatic perennial plant with numerous branches, subshrub, and 30-60 cm tall hairy stems, which is found in all regions of India because tulsi is a worshiping plant in Hindus. Tulsi has been used from medieval times in Ayurveda and Siddha practices for its capability of treating various diseases which are confirmed by the scientist through different pharmacological screenings. Staggering endeavors have been made with the aid of experts to concentrate the concoction and natural capability of the plant. The detailed pharmacological effects of Ocimum tenuiflorum Linn are as an antibiotic, antiseptic, analgesic, CNS depressant, anthelmintic, antipyretic, combats respiratory ailments, lowers blood pressure and reduces stress, treats gastrointestinal disorders, regulates blood sugar, increases immunity and many other effects which are beneficial to the human body. Ocimum tenuiflorum Linn is available formulations are available in the form of tulsi ...

 Atherosclerosis can cause chest pain, dizziness, weakness. The process takes lots of years and is asymptomatic in starting and symptoms appear at a late stage and few times it cannot show any symptoms but leads to more complications. But when mild symptoms appear the stage can be seen. By looking at the plaque phenotype at different stages, the prevention on early treatment could prevent complications. For complete details visit : Monaji Sanjana Reddy. STEPS OF ATHEROSCLEROSIS AND ITS COMPLICATION ,Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 4, 967. August - September 2020, P-2577-2579.

 In the current pandemic situation, a promising, repurposing, or repositioning treatment execution for COVID-19 in association with the therapy which compensates the prevention of critical illness is the immense challenge to global medical science. Although several studies, research works, and analytical research encouraging on already listed agents and potential benefits for COVID-19 but convinced results to remain indecisive. Most of the research work has elaborated about the mild to severe symptoms which further leading to hospitalization, sometimes due to pneumonia, overproduction of pro-inflammatory cytokines (Cytokinine storm). These symptoms are being treated with Remdesivir or Tocilizumab for the stability of patients and to reduce viral loads, through antiinflammatory mechanism or might be reducing mortality rate. But apart from these weighed benefits, still the research field is unanswered about the safety and risk issue of these agents which must be addressed concer...

 Multiple sclerosis (MS) is a disease of demyelinating nature affecting the central nervous system. The chronic inflammation gives rise to plaques in the white and grey matter of the spinal cord and brain regions and also leads to diffuse neurodegeneration in the majority of the brain. Molecular biomarkers for MS are derived from the branches of neurobiology and immunology owing to the causal pathomechanisms. Currently, there is no definite cure for MS and its treatment is mainly centered on the administration of immunosuppressive and immunomodulating agents. Existing management approaches are dedicated to the reduction of biological activity through DMTs, treating acute attacks, and symptomatic treatment. Experimental models are essential to evolving the complexity and pathogenetic mechanisms of the disease and in the design of specific and effective treatments. Various in vitro and in vivo models have been developed in the quest for the design of experimental models of MS. For co...

 Hydroxychloroquine or related antimalarial have shown a wide range of other indications as conditions including diabetes mellitus, malignancy, Dyslipidemia, reducing thrombosis, and many more pleiotropic effects in alone or combination therapy which further helps in reducing cardiovascular events. Considering the global prevalence of diabetes patients and related mortality rates, HCQ has promised hypoglycemic effects through novel mechanisms of action for reducing blood glucose levels. Even it has shown prophylactic blood sugar lowering effect when given in RA or SLE patients. Some studies have revealed antiviral effects also. Considering the current pandemic disease outbreak of COVID 19, USFDA has not approved any therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but several global studies have been under clinical trials because of reducing viral load. So Hydroxychloroquine has come out as a novel milestone with multifaceted uses, long term experience of us...

 BCT is being more frequently used for management of breast cancers. RT is a critical component of BCT. WBRT with an additional boost dose focused on lumpectomy cavity is a widely accepted treatment strategy. While the benefit of adding boost RT to WBRT has been demonstrated with accumulating evidence from several centers around the globe, there may be concerns about adverse effects such as induration, fibrosis, telangiectasia and overall Cosmesis. In this context, normal tissue sparing techniques are being more commonly used in WBRT. BT may offer an excellent method for administering the additional boost dose after WBRT with its inherent advantages of improved conformity and reduced surrounding tissue exposure, which may potentially translate into decreased risk of late effects. This has been supported by several comparative studies and experiences from different centers. Clearly, future studies may provide high level evidence regarding the optimal treatment of patients after BCS....

 Candida albicans is normally present 80% in human body in cellular form but in favorable temperature it forms pseudohyphae and causes infection. Its overgrowth causes diseases like vaginities, oral thrush in infants and dreadful diseases in HIV and cancer patients. The results of our study clearly demonstrated that different extracts of Rhizopus stolonifer, R.nigricans, Aspergillus niger, A.Fumigatus, Penicillum notatum exhibit anti-candidal activity which might be helpful in preventing the growth of these organisms causing various diseases and can be used in alternative system of medicine. For complete details visit : Aakriti Shukla, Dr. Apoorva Pathak.SCREENING, IDENTIFICATION AND ISOLATION OF SOME FUNGAL SPECIES AGAINST OPPORTUNISTIC FUNGAL PATHOGEN CANDIDA ALBICANS , Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 5, 970. October 2020, P-2601-2604.  

 Upcoming proof suggests that antioxidants, oxidative stress, and paraoxonase may also play a part in cardiovascular diseases.[16] Similarly, atherosclerotic heart disease can also result in a heart attack or angina. The frequency and burden of Atrial Fibrillation on a global level calls for an urgent rise for investment in basic and translational research within industries, government, and academia. Important developments in research and newer translation methods are required, so that indispensable scientific challenges can be conquered, which include growing the grasp of AF mechanisms, figuring out and validating targets, creating predictive biologic and computational models, recognizing dependable biomarkers for affected person stratification and as endpoints for medical trials, preventing arrhythmia towards clearing regulatory pathways, and ensuring the reliability and reproducibility of posted data, as properly as information sharing and collaboration. We document the Molecula...

 Exercise is the base of good health. It is necessary to understand its benefits and limitations for the individual, this study reveals the effect of excessive exercise causes metabolic changes and serious health-related issues as mentioned above. Exercise beyond physical strength leads to the destruction of strength and life. For complete details visit : Patel Mayur, Gadhavi Sachin, Hetal Patel. A CRITICAL REVIEW OF THE SIDE EFFECT OF EXCESSIVE EXERCISE ACCORDING TO AYURVEDA WITH CONTEMPORARY MEDICAL SCIENCE , Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 5, 972. October 2020, P-2592-2594 .

 Synchronous use of systemic treatment with RT after BCS allows for shortened treatment time without any delay in use of both modaities, and may exploit the biological interplay of both modalities to achieve a potentially greater anti-tumoral effect than that could be achieved by their sequential administration through different mechanisms such as radio-sensitization. Vigilance is required for toxicity monitoring during the course of synchronous treatment, nevertheless, contemporary technologies including adaptive RT and breathing adapted RT may improve the toxicity profile of management. Clearly, further investigation is needed to shed light on optimal sequencing of treatment modalities after BCS. For complete details visit : Omer Sager, Murat Beyzadeoglu, Selcuk Demiral, Ferrat Dincoglan, Hakan Gamsiz, Bora Uysal . UTILITY OF SYNCHRONOUS CHEMO RADIOTHERAPY AS A VIABLE ALTERNATIVE TO SEQUENTIAL CHEMOTHERAPY AND RADIOTHERAPY (RT) AFTER BREAST CONSERVING SURGERY (BCS), Journal ...

 The current review records a few dangerous components of dental caries which had various mediations to prevent caries. Since broad harm from caries can prompt major issues for the individual, influencing personal satisfaction both functionally and aesthetically. Expanding the awareness and information about dental caries, by and large, can build their information and skill in oral medical services. Having the ability to distinguish potential wellbeing hazard factors, for example, way of life, ethnicity, wellbeing status, and social determinants associated with oral wellbeing status hazard, medical services suppliers can play a major role in dental preventive services and identifying medical issues. With legitimate information and oral wellbeing conduct, medical services professionals can assume a significant function in the oral wellbeing education of people and gatherings and go about as good examples for patients, companions, families, and the network on the loose. Great general...

 By the above discussion these four medicinal plants are Balya (Tonic- Promotes strength), Vrishya (Acts as aphrodisiac), Rasayana effect (Act as tissue vitalizer). These plants alleviate the Shosha (Emaciation), Daha (Burning sensation), Jwara (Fever). The name Parni is given to the plants as they appear and reassemble of the particular plant. For example Shalaparni (Desmodium gangeticum (Linn), DC) means its leaves resembles the shape of the Shala (Shorea robusta Gaertn) tree(Leaf is ovate in shape). The Prishniparni (Ureria picta Desv) means it has very few leaves and painted with colors.      The Mudgaparni (Phaseolus trilobus Ait) can live and easily be boiled even with very little quantity of water. This type of Mudga will grow against all odds i.e even in forests. The Mashaparni (Teramnus labialis Spreng) leaves resemble those of Masha (Phaseolus mungo Linn). Here an attempt was made to highlight the botanical source, Pharmacological actions were elaborated sy...

The survey is clearly explaining that eating habits play a major in psychological and physical appearances in college students. Eating unplanned meals not only causes fat deposition it results in critical mental changes in college students regarding their physical appearances. Health care team like unionist may conduct special awareness programs to advice the youngsters regarding their food and habits and its clinical outcomes. This data shows the exact mindset of college students regarding their food habits. Furthermore, the analysis required to overcome nutrient oriented disorders. It has been hypothesized that food plays a more role in energy production and many major activities. We believe this research will create a special awareness in understanding impact and consequence of eating disorder among all the college girls in Chennai city. For complete details visit : Dr. B. Gowsalya, Dr Joseph Maria Adaikalam . ASSESSMENT OF KNOWLEDGE REGARDING EATING DISORDERS AMONG COLLEGE GIRL...

 Cetilistat, diiodohydroxyquinoline, abiraterone, bexarotene, hispidin, lepidine E, folic acid, curcumin, maraviroc, glecaprevir, Sofosbuvir, MSC transplantation, RUX, baricitinib, eculizumab, blood purification, ECMO, and TCM were identified and demonstrated benefits in various in vivo and in vitro studies of COVID-19. These miscellaneous groups of drugs have the potential to interfere with viral replication, reduce viral load, modulate the immune function, oxygenation, and thereby reduce clinical symptoms, severity, mortality, and transmission of the disease. It may also reduce the burden on the health sector. For complete details visit :  Mathew Steffi Rose. MISCELLANEOUS THERAPY FOR COVID-19. A SYSTEMATIC REVIEW, Journal of Medical Pharmaceutical and Allied Sciences, V9-I6, 979. November-December 2020, P-2610-2617.

 Type 2 DM is a metabolic disease that can be prevented through lifestyle modification, diet control, control of overweight and obesity. Education of the populace is still key to the control of this emerging epidemic. For complete details visit :  Roshan Kumar , Purabi Saha, Priyatosh Pathak , Ramayani Mukherjee , Abhishek Kumar, Rakesh Kumar Arya. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS Journal of Medical Pharmaceutical and Allied Sciences, V 9-I 6, 956. November-December 2020, P-2605-2609.

 The enhanced delivery of tazarotene using niosomes can be ascribed to an interaction niosomes and skin lipids. The drug release deeply into the skin and transdermal absorption of drug may due the fusion of niosomes with skin lipids and drug releases occurs at various points along the penetration pathway. It was concluded that niosomes loaded with Tazarotene gel formulation possessed prolonged action and it will be developed successfully against the dermal infections. For complete details visit : Roshan Kumar, Purabi Saha, Priyatosh Pathak, Ramayani Mukherjee, Abhishek Kumar, Rakesh Kumar Arya. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Journal of Medical Pharmaceutical and Allied Sciences, V9-I6, 956. November-December 2020, P-2605-2609.

 Between 1982 and 2016, three thousand eight hundred and thirty-four pediatric cancer cases are registered in the Madras Metropolitan Tumor Registry. The long-term trend indicates that childhood cancer gradually decreased during the recent years (2012-16) while maximum cases are reported during 2007-11.The results show a higher incidence of cancer among the male children (60.3%) of 0-4 years of age. The prevalence of cancer was found more common in 0- 4 years of age except for lymphoid leukemia, NHL, Hodgkin’s disease, brain tumor, and kidney cancer which were found high among children of 5-9 years of age. Leukemia is the most common pediatric cancer and it constitutes 27 percent in males and 25 percent in females. Across the social groups, more cases are reported from the Hindu community, while specific types like myeloid leukemia, NHL, brain tumor, and multiple myeloma are found high in the Jain community. Similarly, lymphoid leukemia and rectum cancer are more common among ...

 FDTs are dosage forms that are formulated to dissolve/disintegrate rapidly in the saliva generally within few seconds. They are specially designed to overcome some of the problems seen in conventional solid dosage form i.e. difficulty in swallowing the tablet in the elderly and for children, especially for infants. FDTs are structured to dissolve or disintegrate swiftly when coming in contact with saliva generally within 60 seconds (range of 5-60 seconds). Fast dissolving tablets have widely accepted patient compliance and acceptance and may improve biopharmaceutical properties, bioavailability improved efficacy, convenience, and better safety compared with conventional oral dosage forms. The popularity of FDTs has increased fabulously over the last decade. FDTs should be developed for psychotic patients, bedridden, geriatric, pediatric patients, patients who is facing scarcity of drinking water, patients who are travelling most of their time. FDTs formulations formulated by ...

 In the present study, 98 patients with implantation of pacemaker who completed 12 months follow- up were enrolled.  ➢ Mean age was 65.92 ± 9.64 years with 60.2% male.  ➢ More prevalent comorbid condition was hypertension (49.5%) followed by diabetes mellitus type II (24.5%), coronary artery disease (9.2%),hypothyroidism (4.1%) and cerebrovascular accident (2.0%).  ➢ Most common indication for pacemaker was complete heart block (85.7%) followed by high degree AV block (14.3%).  ➢ No patients had developed congestive heart failure or atrial fibrillat ion at 12 months of follow-up.  ➢ Paced QRS had a significantly increased at 12 months of follow-up . Our is a prospective study of 98 patients without any structural heart disease, who were implanted with single chamber pacemaker with RV apical pacing and having pacing of more than 90%, over a one year follow- up period. The patients remain asymptomatic for heart failure and arrhythmias on follow-up. The QRS du...

 Healthcare workers remain at increased peril of moral harm and mental health problems and need to proactive steps to protect their mental wellbeing during this COVID-19 pandemic. HCWs must be vigorously monitored, supported, and, where necessary, provided with evidence based treatment. Reducing stress by capitalizing on coping policies akin to encouraging lifestyle behaviors can enormously improve mental health well-being. Continuing convention with loved ones either direct or through social media with maintaining precautions also helps to reduce fear and anxiety. Engaging in habitual physical work, eating healthy food, practicing good sleep hygiene where possible, and guaranteeing sufficient rest and breaks between shifts have been recommended by the WHO. Avoid tobacco and consumption of alcohol or other drugs also beneficial for mental health. For complete details visit : Ramakant Yadav, Ankur Vaidya, Raj Kumar, Shweta Jain, Ajay Kumar Shukla, 2021. Psychological distress i...

 FDE is a fairly common drug eruption. Because of recurrences, it is important to recognize FDE and its causative trigger to avoid recurrences in the future by the administration of the same or structurally related drug. FDE is difficult to diagnose when it manifests as atypical cutaneous lesions. Hence, a clinician should be aware of the variants of FDE and be able to differentiate from diseases with similar lesions and detailed drug history should be taken in cases with high suspicion index. Very few cases of FDE (including a case of generalized non-pigmenting bullous FDE) due to Mefenamic acid has been reported previously in the literature. [2][3][4] Mefenamic acid is frequently taken without any medical advice and is usually forgotten by patients. For complete details visit : Das Somnath, Chatterjee Gobinda, Nayak ParthaSarathi, Prakash Aishwarya, Rudra Olympia, Mandal Aniruddha, 2021. Bullous eruptions in a patient of systemic lupus erythematosus. Jour. of Med. P’ceu...

 Liver is the body's heaviest gland that performs a variety of functions, including synthesis, storage, digestion, excretion. Up to today, only Ayurvedic formulations were available for the treatment of liver disorders. Synthetic molecules were prepared using synthetic molecules for generic drug applications. Tablets were coated using Opadry Pink 21K540020® as a coating agent to enhance physical appearance, and provide moisture safety. The goal was to achieve tablets with the same disintegration time as innovator tablets to obtain f1 value less than 15, and an f2 value of more than 50. All the stability samples were prepared as per optimized formulation and kept for stability study as per ICH guideline Q1A (R2) at 40°C ± 2°C/75% RH ± 5% RH, 30°C ± 2°C/65% RH ± 5% RH and 25°C ± 2°C/60% RH ± 5% RH. Six months stability data at 40°C ± 2°C/75% RH ± 5% RH were found within specifications. For complete details visit : Prashant L Pingale, Sunil V Amrutkar, Darshan R Telange, 2021. Fo...

 Current cancer treatment management and drugs have several limitations like new drug resistance, doselimiting toxicity, the non-specific bio-distribution of the cancer drugs. These several limitations lead to the development of a liposomal drug delivery system very rapidly to cure cancer patients with the limited side effect. Various ways of supramolecular designs have been discussed which can be incorporated alongside drug delivery systems and drug design strategies to improve the treatment of cancer. The long history of the use of macro-cycles as drug carriers, whereby a guest drug is included within a host carrier, is one proven example. Advances in recent years for the creation of supramolecular materials offer opportunities to develop controlled release depots, which may further be designed to respond to a specific biomarker or disease indicator. These materials may themselves elicit drug-like function, either through therapeutic bio-mimicry or through bioactivity associated ...

 From this paper and previous reports and literature, it is confirmed that Emblica officinalis has tremendous biological potential and can be successfully used for the treatment and management of variety of ailments. The results for these studies are so much satisfactory and therefore this plant is considered in the Ayurvedic and Chinese medicines. However, there is a need for further standardization and isolation of its active constituent because there is tremendous scope for further research. This drug can be used as a precursor or as an active ingredient for the preparation of various medicines in the pharmaceutical industry. This review therefore will provide satisfactory and effective evidence for its use in preparation of different medicines. For complete details visit : Deshmukh Chinmay Devidas*, Choudhari Shradha Pramod, 2021. Phytochemical And Pharmacological Profile Of Emblica Officinalis Linn. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 2, 1054. P-2698-2703. ...

 From the results of current investigation, reveals that more number of patients faces the moderate or severe pain in the postoperative conditions, even though there were standard treatment guidelines for effective against postoperative pain. Analgesics may be failure to show effectiveness in some population. The current study concludes the type of department, occupation, genetics may show impact on severity of pain. For complete details visit : Vrushali H Talmale*, Rahul H Kasliwal, Yogesh N Gholse, 2021. Current Updates On Herbal Oil Vs Synthetic Antibiotics Use For Topical Application. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 2, 1051. P-2688- 2697. DOI: 10.22270/jmpas.V10I2.1051.

 Complementary and alternative remedy has given the new wish to reduce the unwanted effects of synthetic drugs. Antibiotics to the above information, we can conclude that the herbal oils are more effective than synthetic antibiotics for topical application. Oils are easily penetrate into the skin barrier for treatment of skin condition. Herbal oils are also beneficial for topical application but they possibility to produce local hypersensitivity reaction and slower the rate of penetration into the skin surface. However, an antibiotic can be bactericidal at excessive dose and bacteriostatic at a minimum dose its effectiveness may be determined through well-known test which may be misleading as predictors of medical efficacy for unique antibiotics. So, that the herbal oils are beneficial to treat skin condition. For complete details visit : Vrushali H Talmale*, Rahul H Kasliwal, Yogesh N Gholse, 2021. Current Updates On Herbal Oil Vs Synthetic Antibiotics Use For Topical Applica...

 From the trial-and-error optimization design, drugloaded Gatifloxacin Niosomes were successfully evaluated. Pre-formulation study confirms the purity of the drug and compatibility of the drug with excipients using FT-IR and DSC study. Tween 80 was found significant with the experimental results. It was confirmed that increasing the concentration of Tween 80 increases the deformability of niosomes. From characterization parameters and stability study, it was concluded that the formulation has acceptable morphology and particle size, no any chemical interaction, and was stable at refrigerated condition respectively. An extensive investigation is needed regarding the depth of penetration into the skin, determination of zeta potential, and confirmation of configuration of phospholipids in the lipid bilayer. There is a need to develop a suitable formulation for commercial exploitation. Thus, the specific objective listed in the plan of work of this thesis were achieved namely design, c...

 Endometrial Hyperplasia is the abnormal condition of the endometrium. The lining of the endometrium becomes thick due to increased proliferation of the cells (hyperplasia). It is not a cancer but it is a pre-cancerous condition that may lead to cancer. This condition of endometrial proliferation is caused by certain medical conditions such as PCOS (polycystic ovarian syndrome), lynch syndrome (hereditary non-polyposis colorectal cancer), chronic anovulation, obesity etc. Sometimes in rare cases it is asymptomatic or symptomatic such as abnormal uterine bleeding with or without pain, bleeding between periods, menorrhagia etc. On experiencing these symptoms, endometrial samples are collected from the patients. Before collection of samples trans vaginal ultrasound is preferred in order to ensure the endometrial thickness. Endometrial samples are collected by Biopsy, D&C. EH is treated based on the type. Surgery is not considered as the first-line treatment for endometrial hyperpl...

 Glycemic regulation is easier in spinal anesthesia than in general anesthesia since the stress response to surgery is comparatively lower. Where necessary, we prefer spinal anesthesia to epidural and general anesthesia for minimizing surgical stress response. Other factors that can influence the stress response and blood glucose level were not addressed in the report. As compared to a similar technique in the nondiabetic community, surgical tension is higher in the diabetic group in both techniques. Wherever possible, regional techniques can reduce a diabetic's response to surgical stress. The need for an intraoperative insulin regimen may not be required in all procedures, but it is more dependent on the length and severity of the procedure. Increased blood glucose levels in general anesthesia may be due to a blunting of the stress response during endotracheal intubation or pain during the intraoperative phase, which were not clarified in the research. For complete details v...

 This study examined whether there is a difference in children's psycho-social development variables according to the presence of children's atopic dermatitis symptoms, and analyzed the relationship among variables. In the results of comparing the difference in the problem behavior factors of young children according to the presence or absence of atopic dermatitis symptoms, it was found that there were significant differences in internalization and externalization of problem behavior. The score of problem Behavior of children with atopic dermatitis symptoms was higher than that of no-symptom children.2, 4, 5 Second, it was reported that children with atopic dermatitis tend to be immature and unsociable compared to healthy children.4 but in this result, the sub-factors of peer interaction such as play interaction, interference with play, and play break according to The presence or absence of atopic dermatitis symptoms showed no difference between groups.8,14 In the other case o...

 Women, in particular, have more to do with changes in their sleep patterns than men, and have more sleep disturbances than men. In other words, it can be seen that women have many sleep-related problems, such as lower quality of sleep compared to men and complaining of more sleep disorders.9 In this study, we are trying to provide basic data to help establish a program to help in-crease the quality of sleep in middle-aged women with non-drug interventions with fewer side effects that can improve sleep effects. Based on these findings, the presence or absence of disease and daytime drowsiness were factors influencing the sleep quality of middle-aged women? The more severe the daytime drowsiness and the presence of the disease, the worse the sleep quality of middle-aged women. Therefore, when developing nursing intervention for improving sleep quality in middle-aged women, it is necessary to consider the conditions of disease and daytime drowsiness identified in this study. this res...

 This study attempted to provide the basic data for the development of health education programs for the management of the PMS symptoms in female college students by examining the behavior caused by the exposure to endocrine disruptors in female college students and the degree of the premenstrual syndrome, and understanding the correlation between the variables. There were statistically significant differences in the premenstrual syndrome depending on the risk of an exposure to endocrine disruptors. In addition, there was a significant positive correlation between the exposure to endocrine disruptors and the premenstrual syndrome. Endocrine disruptors may pose a health threat to indi-viduals or their offspring such as women's breast cancer, increased infertility and malformations, attention deficit, and increased number of children with learning disabilities. I think it is very important to remind female college students about the risks that endocrine disruptors pose to the endocri...

 In the surgical area, acute intestinal obstruction is still a major surgical emergency. Intestinal obstruction is often caused by postoperative adhesions. Early operative procedures, in combination with clinical diagnosis and radiological findings, may enhance the outcome of acute intestinal obstruction. When clinical and initial traditional radiographic results are inconclusive or strangulation is suspected, a CT scan is recommended for evaluation. While, with a better understanding of pathophysiology, improvements in diagnostic methods, fluid and electrolyte correction, more potent antimicrobials, and intensive care information, mortality from acute intestinal obstruction is decreasing. For complete details visit : Dr. Samadhan Patil, Dr. Pradeep M. Wagh, 2021. “Study of surgical management of intestinal obstruction from central india: a cross sectional study”. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1231 P-3070-3073. DOI: 10.22270/jmpas.V10I3.1231.

 Shivering caused by post-spinal anaesthesia can be effectively treated with Dexmedetomidine and Tramadol Hydrochloride. As compared to Tramadol Hydrochloride, Dexmedetomidine takes less time to suppress shivering. It has an advantage over Tramadol Hydrochloride in that it has less side results such as nausea and vomiting. Shivering is caused by a complex network of neurotransmitter pathways including opioids, -2 adrenergic, serotonergic, and anti-cholinergic receptors. In order to avoid or treat this disorder, drugs that operate on these mechanisms are used. Dexmedetomidine's anti-shivering activity has not been thoroughly studied. Dexmedetomidine, like clonidine, is linked to a reduced incidence of shivering. The vasoconstriction and shivering thresholds were decreased after an intravenous infusion of dexmedetomidine. For complete details visit : Dr. Shraddha Naik, Dr. Ashutosh Bahulekar, 2021. “Comparison of tramadol hydrochloride and dexmedetomidine for the management of i...

 Our immune system is a system provided with self-defensive mechanism in order to shield the host from pathogenic microorganisms and exogenous noxious agents within our environment. Many mechanisms get used by the immune system to combat infection by microbes. Toxic or allergenic components entered through surfaces of mucosa get erased by the host’s immune system. It responds to foreign pathogens and cancer cells by activating specific and non-specific immune responses. The different sources which are depicted in this article might be useful for the readers to maintain a good immunity to fight with many diseases which are uncontrollable now-a-days. For complete details visit :  Gottipati Kavya, Darsi Eswar Tony, Ankem Narendra Babu, Rama Rao Nadendla, Yerram settee Gayathri, Kanda Bala Bhavana, 2021. Prosper the immunity through diet – a must in unease situations. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1093 P-2979-2983. DOI: 10.22270 /jmpas.V10I3.1093....

 In Kasisadi Ghruta, the ingredients used are Shothahara, Veda nasthapana, and Ropana which is why it assists in Fissure Heal ing in Ano. Along with diet and oral care Kasisadi Ghruta med ication maybe the best choice for Healing wound without any hand of Parikartika Repercussions. For complete details visit : Kukade S, Mate M, Thakre A, 2021. Clinical assessment of a local application of kasisadi ghritain parikartika (fissurein-ano). Jour. of Med. P’ceutical &Alli. Sci. V 10 - I 3, 1159 P-3059-3060. DOI: 10.22270/jmpas.V10I3.1159.

 It is evident in conclusion that PCOS is an enigma. There is no complete understanding of its fundamental pathophysiology as per modern science. No therapy is a panacea, as therapies have so far been targeted at the symptoms but not at the syndrome itself. To make treatment more effective and to postpone the severe long-term effects of the disease on the health of patients, comprehensive attempts should be made to thoroughly examine the syndrome. In this scenario, Ayurveda throws clear light on the pathophysiology of PCOS. Hence accordingly, treatment for the disorder can be planned. For complete details visit :  Andhare R, Jadhao S, Shrivas Y, Gabhane S, Thakre A, 2021. Multiple approaches in ayurveda for pathophysiology in polycystic ovarian syndrome. Jour. of Med. P’ceutical &Alli. Sci. V 10 - I 3, 1158 P-3022-3026. DOI: 10.22270/jmpas.V10I3.1158.

 Here the sample genuine Ativisha with both small and big sized starch grains and taste is bitter followed by salivation in the mouth it may official Ativisha. Where the other sample with big starch grains with sweet taste may be adulterated market sample sold under the name of Ativisha. Though this groundwork requisites for preliminary pharmacognostic standardization of Ativisha is covered in the current study, additional important analysis and investigations are required for the identification of all the physico-chemical characters of test drugs to substantiate the clinical efficacy. For complete details visit : Khobragade P, Rathi B, Hande M, Nagpure S, 2021. Preliminary comparative pharmacognostic study of genuine and adulterant raw material in ativisha (aconitumheterophyllum wall. ex royle). Jour. of Med. P’ceutical &Alli. Sci. V 10 - I 3, 1157 P-3051-3054. DOI: 10.22270/jmpas.V10I3.1157.

 Management of Hypothyroidism with synthetic thyroid hormone derivatives may bring the value of TSH, T3 and T4 to normal range but the daily intake of medicine for lifetime, the known side-effects thereafter and increase in the dosage with time as the disease become chronic, is troublesome for the patients. Also the quality of Life of the patients taking medicine regularly for long durations is compromised. The consequences of Subclinical thyroid disease are minimal, hence routine treatment - Levothyroxineis not necessary. Management of patients with a serum TSH level less than10mIU/L is controversial. Hence, Ayurvedic medicines orformulations can be used as independent therapy in management of Subclinical Hypothyroidism. If Subclinical Hypothyroidism goes untreated, it may lead to Clinical Hypothyroidism in some cases. Hence, Ayurvedic medicines orformulations, which will cure the root cause of the disease by addressing all the factors of Samprapti or pathogenesis of Hypothyroidis...

 Since the patient was old, having low immunity from such a long time combination therapy was given and marked improvement was found in all signs and symptoms. This case is a successful presentation of the management of an acute condition like visarpathrough combination therapy. It has shown relief in the symptoms of visarpa like daha and pidika. Use of kashaya - tikta rasa pradhan shaman aushadhihas relived kanduand toda. Based on the conceptual analysis and observations made in this clinical study, the following conclusions are drawn. The disease herpes zoster in modern medicine and visarpa has a lot of similarities, particularly pittaja and vatapittaja visarpascan be correlated with herpes zoster. Elderly people are more prone to this disease. The disease herpes zoster in modern medicine and visarpa has a lot of similarities, particularly pittaja and vatapittajavisarpascan be correlated with herpes zoster. Ayurvedic treatment with antiviral acyclovir as a combination therapy has...

 Out of the six drugs stated by Kashyapa for treating eye diseases some are common with other textbooks and well known. They have been traditionally used by local people with good results for years but there is a need to re-establish the use of these drugs in prophylaxis and management of eye conditions in a scientific way including standardization and aseptic use of these drugs. This urges further in-vitro and invivo research studies to understand the role of Chakshushya, Mata, Pushpanjan, Gorochan, Rasanjan, and Katak specifically in ophthalmic conditions. For complete details visit : Shrivas Y, Andhare R, Shamkuwar S, Salankar H, Nagpure S, 2021. Indigenous drugs for eye disorders in shatkalpa adhyay of kashyapa samhita: A review. Jour. of Med. P’ceutical &Alli. Sci. V 10 - I 3, 1153 P-2999-3004. DOI: 10.22270/jmpas.V10I3.1153.

 Ancient Acharyas have stated a multidimensional approach towards the management of Darunaka. The multidimensional approach of Ayurveda towards management of Darunaka in the form of Shodhana Chikitsa, Shamana Aushadhis, and Sthanika Chikitsa along with Nidana Parivarjana gives satisfactory results to the patient. These leaps (paste) nourishes the scalp and restore moister balance, eliminate dandruff and scalp infections, reduces scaling and irritation of the skin cell repair, and rejuvenate the tresses effectively. Being an anti-fungal, anti-bacterial, antiinflammatory agents; this lepa helps to eliminate fungal growth, bacterial infections and inflammation due to scratching the scalp and treated the issue of dandruff. Thus, the combined effect of Shodhana Chikitsa and Shamana Aushadhis along with Sthanika Chikitsa gave excellent results in reliving the complaints of Darunaka. For complete details visit : Wairagade S, Wairagade T, Giri D, Singh S, Singh A, 2021. A review of ay...

 The present study was undertaken to evaluate physicochemical standards of viparit lajjalu (biophytumsensitivum linn.) And its effect on sperm and quality of sperm in adult male wistar rat. In our daily activities, medicinal plants are widely used by traditional medical practitioners to treat various diseases. One of those used as traditional folk medicine is in various conditions such as stomach ache and burning sensation, inflammation, arthritis, wounds, gonorrhea, amenorrhea and dysmenorrhea, asthma, cough, degenerative joint disease, urinary calculus, diabetes, snake bite, viparitlajjalu (biophytumsensitivum linn) of the family oxalidaceae. It has ethanobotanical articles that explain the aphrodisiac activity and sterility activity of the same plant. Due to different opinions on the activity on sperm of b. Sensitivum linn, the proper scientific study should be done for an accurate conclusion of the effect on sperm. Thus, there is a requirement to study the effect of b. Sensitiv...

 All the method validation parameter performed for development trail 03 and found all parameter within acceptance criteria. During method validation system suitability of each parameter was found within limit. In specificity no placebo and other interference was found and in force degradation studies we obtained desired degradation on Acid, base and peroxide conditions. In Linearity both ezetimibe and simvastatin with their relevant impurities correlation coefficient within acceptance criteria simultaneously we performed Accuracy, precision, solution stability and filter equivalency and result obtained in each of parameter was well within limit. Method validation performed As per ICH guidelines Q2 (R1). For complete details visit :  Neelu Jain, Srinivasarao Kosanam, Surendra Singh Rao, Asheesh Singh, 2021. Cost effective stability indicating rapid, efficient analytical method development and validation of related substances method for simultaneous determination of simvast...

 After considering the assessment parameters of dissolution study, disintegration time, and wetting time, an excellent batch of fast disintegrating tablets was selected. Batch FB3 of fast disintegrating tablets (containing 12 mg, or 6%, of dehydrated banana powder) were chosen as the best batch because of drug release using dissolution study, disintegration time, and wetting time. The maximal in-vitro cumulative percentage release of the drug from FB3 was 97.75 ±1.74. For complete details visit : Prashant L Pingale, Sahebrao S Boraste, Sunil V Amrutkar, 2021. Formulation and Evaluation of Pravastatin Fast Disintegrating Tablets using Natural Superdisintegrant. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 2, 1450. P-2977-2981. DOI: 10.22270/jmpas.V10I2.1450.

 The novel benzofused heterocylic compounds were synthesised and characterised as derivatives of 2-(1H-1,2,3- Benzotriazol-1-yl)-N-substituted acetamide. When compared to standard drugs, the compounds showed moderate antimicrobial activity. Increased dosages of the respective compounds resulted in increased activity. The findings also showed that synthesised compounds could be more effective antifungal agents than antibacterial agents. According to a docking analysis, this compound has antimicrobial activity. Compound BT6 possesses the best antimicrobial activity. For complete details visit : Patil tejaswini d., amrutkar sunil v., 2021. Design, insilico screening, molecular docking, synthesis and biological evaluation of benzo-fused five membered nitrogen containing heterocycle against dna gyrase subunit b as potential antimicrobial agent. Jour. Of med. P’ceutical &alli. Sci. V 10 - i 3, 1176 p- 3040-3047. Doi: 10.22270/jmpas.v10i3.1176.

 Diagnosed and confirmed cases of either sex between the age group of 40 to 60 years having Patients with cardinal signs and symptoms of Amsasandhishoola(shoulder pain), Amsasandhistabdhata(shoulder stiffness), Sparshaasahishnuta(Local tenderness), Bahupraspandhitahara(Restricted movements of shoulder region), with or without Amsasosha(muscle wasting). For complete details visit : Wairagade S, Kumar S, Wajpeyi S, Dandekar P, Bhawane A, 2021. Comparative clinical study of amsabasti and snehan – swedan therapy by laghuvishgarbha tail along with trayodashangguggulu in avabahuka (frozen shoulder). Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1150 P3011-3015. DOI: 10.22270/jmpas.V10I3.1150.

 The review finds that the most explored and now and again used therapeutic plants for the treatment of hypertension are Jatamamsi, Sarpagandha, Rason, and Arjuna. Moreover, we found that there are logical confirmations of the utilization of some Ayurvedic herbal plants for the treatment of high BP. There should be rational use of these drugs in hypertension and need to increase the demand to all doctors worldwide.      There is a need for further research to identify the gaps in previous research studies. For complete details visit : Bhokardankar P, Rathi B, Kukade S, Gupta R, Bhawane A, 2021. Critical review on potential ayurvedic drugs functional in hypertension. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1149 P-2917-2920. DOI: 10.22270/jmpas.V10I3.1149.

 Sprint measurements quantified the improvements in running speed by both FIFA 11+ as well as the Harmoknee warm-up program. All the groups FIFA 11+, the Harmoknee and control showed significant improvements in vertical jump height. None of the warm-up programs produced a significant difference in the kicking accuracy of the athlete. Athletes from both groups showed significant improvements in the Illinois agility test whereas no significant changes were seen in the Control group. It is concluded that no clear superiority could be established between FIFA 11+ and the Harmoknee warmup program. Both the programs improve physical performance in elite football players. For complete details visit : Sayyad A, Kahile M., Deshmukh N, Guhe A, Chandi D, Bhoyar K, 2021. Effects of the FIFA 11+ and harmoknee warm-up programs on physical performance measures inindian elite football players (an experimental study). Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1148 P-3001- 3006. DOI...

 The following conclusions were drawn based on the finding of the study. The finding of the pre-test showed that none of the patients had adequate knowledge on awareness of postoperative self-care among cataracts. After the planned teaching program although they had gained knowledge about post-operative self-care. The paired ‟test which was computed between pre-test and post-test knowledge scores indicates a true gain in knowledge. Hence it was concluded that planned teaching program as an effective method to improve the knowledge among the patients. For complete details visit :  Ms. Pratiksha Kamdi, Ms. Ruchira Ankar, Ms. Madhavi Narayane, Dr. Swapnil Bhirange, 2021. To assess the impact of proposed teaching programme on post-operative self-care among cataract patients. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1147 P-2997-3000. DOI: 10.22270/jmpas.V10I3.1147.

 In short, as seen here by the study of three cases, the concept of Samanya and Vishesha has good applicability. Rather, some of these are so robust that they are widely applicable across structures and fields of knowledge, including science, technology, and humanities, as well as science, experience and conventional knowledge systems, as applicable from Ayurveda. In order to justify the need to investigate other Ayurveda concepts from the perspective of broader applicability, the findings have significant implications, which can in turn demonstrate their robustness across information domains. Another implication was that attempts should be made in research studies to recognize the relative effect of Samanya Vishesh in clinical environments. This may provide new insights into the development of more robust clinical approaches. For example, Ayurveda recommends various food products as safe and healthy for the body, but it can be researched to understand the degree of Vishesha t...

 The present modality of integrated yoga therapy as adjunct therapy may serve as an alternate therapy for hypothyroid disorders. If this proves successful further studies may be done on different endocrine disorders. For complete details visit : Tiwari M, Dandekar P, Desai P Wanjari A, Bhirange S, 2021. Comparative evaluation of structural and functional changes in thyroid gland after implementation of integrated yoga module (iym) as adjunct therapy versus conventional levothyroxine therapy in hypothyroid females. Jour. of Med. P’ceutical & Alli. Sci. V 10 - I 3, 1145 P-2989-2992. DOI: 10.22270/jmpas. V10I3.1145.

 The availability of proper ventilation to every urban building or house reduces personal exhaustion and filter air properly to refresh air and Sunlight which is coming from the window. People recommend that saturation and fatigue in filtered air or fresh air be minimized by complying with all-natural air ventilation as per WHO guidelines. If the use of fans is inevitable, the possible spread of any airborne or aerosolized viruses can be minimized by the outdoor air exchange and minimizing the air flowing from one person directly to another. Well-controlled and regulated air conditioning and ventilation systems should not raise the risk of transmitting viruses. In single-occupancy rooms, ventilators are safe. When several persons are present in this room, fans for air circulation in collective spaces should be avoided. Both air conditioning and industrial ventilation systems for both residential and high-occupancy buildings (government buildings, schools, hotels, and hospitals) sho...

 Ayurveda is an ancient Indian system of medicine; in fact, it is the world’s oldest healing science. Ayurveda means “the science of life”. This is made up of two words – ‘Ayur’ which means “longevity” or “life” and the other is ‘Veda’ which stands for “science”. Ayurveda believes that each individual is unique and made up of three Doshas, that is - Vata, Pitta, and Kapha. When these Doshas become assimilated, it will lead to diseases. The digestive fire or Agni is another important aspect that plays a role in overall health. If it is impaired, it may lead to the accumulation of toxins/ poisons and can further lead to various diseases. Hence restoration or strengthening of the Agni and balance of the three Doshas is very essential for good health. For this periodic cleansing is suggested which works both as curative and preventive because of its rejuvenating action. One of the prominent branches of Ayurveda is panchakarma meaning "Five procedures" as it consists of five techn...

 We all agree that online learning is a new normal way to learn almost anything. Initially, students were not adaptive towards online learning but with time they have become comfortable and now prefer online learning. The reason identified for preference towards online learning is suitable assessment, time-saving which enables students to do additional work and provides an environment for self-learning. However, some of the students feel that they are not getting full attention from the teacher in online class compared to the traditional classroom environment. Some of them also feel puzzled & frustrated with the content delivered in an online class. Although online learning has a significant role to play in India in near future, it is at its very nascent stage & requires more efforts from teachers & HEIs to make it more effective & comfortable for students. In conclusion, it cannot be a replacement for traditional face-to-face classroom learning. To addresses t...

 Tinospora cordifolia is a plant with a diverse role as it is an accomplished source for all kinds of life. Several plant extracts have potential compounds in active forms. The above vital ingredients have physiological and biological functions, hence illustrating the different adaptability of Tinospora cordifolia. Researches have to take place including features of interaction of the active ingredients with living organisms and their effects on the structure-function correlations, it can also lead us to the active resources of nature which will lead us to various interactions between the evolving and evolutionarily linked organisms. Advances have to be made in developing the important pathways including biochemical for the important constituents of Tinospora cordifolia, empowering active infection targeting. With all such potential benefits, Tinospora cordifolia functions as a spectacular source of therapeutic advancements. For complete details visit :  Saiee P Joshi, Sa...

 Though COVID-19 has created many challenges, various new streams of opportunities are also coming out. Online education has grown over the last few years and has experienced mainstream acceptance. To develop a deeper understanding of degree courses students get to control their learning environment with an online class. New models and materials of learning are always springing up in the market, Due to this various opportunities for furnishing their study. The future of online degree education looks promising and opens up education to a larger section of the population than ever before. For complete details visit :  Dhole S, Tiwari M, Andhare R, Gabhane S, Dakhode S, 2021. Covid 19 and academics-advantages and disadvantages. Jour. of Med. P’ceutical &Alli. Sci. V 10 - I 3, 1141, P-2961-2964. DOI: 10.22270/jmpas.V10I3.1141.

 In this review we discussed about medicinal plant for treatment of Diabetes mellitus. It showed that these plants have hypoglycaemic effects. Numerous new bioactive compounds isolated from herbal plants having anti-diabetic effects exist anti-diabetic activity. However, several other bioactive agents obtained from medicinal plant have not been well characterized. In-addition investigations have to be carried out to assess the mechanism of action of herbal plants with anti-diabetic effect. At the same time, this review study has shown various mechanisms of action and active components in plants which have greatly enhanced our understanding on the rationale underpinning popular usage of some plants for the prevention and treatment of diabetic complications in order to develop effective medicines for the prevention and treatment of diabetic complications. The side effect of these herbal plants should also be elucidated. We have focused on herbal plants belonging to numerous dive...