Journal of Medical Pharmaceutical and Allied Sciences

  Abnormal stress due to poor posture and work environment are contributing factors in musculoskeletal adaptations resulting in problems like neck pain, back pain, shoulder pain, etc. The scapula plays several roles in facilitating optimal shoulder function and it is very important for the function of the upper extremity. Thereby impact of work-related posture & stress on computer professionals with scapular dyskinesis should be established. 350 male computer professionals (Mean Age = 34.89±8.51 years) following written informed consent were recruited from IT companies and volunteered for this study. Computer professionals involved in fieldwork, with BMI ≥ 25 Kg/m2, having congenital postural deformities, undergone neck/shoulder surgeries were excluded from the study. Each professional was examined for scapular dyskinesis using Kibler’s rating system (Yes/No method). Professionals were then examined for Work related posture using - Rapid Office Strain Assessment (ROSA) & Ra...

  The preliminary studies showed that Melaleuca cajuputi essential oil (MCEO) contained several phytochemicals of antidepressant and anxiolytic properties. Therefore, the aim of this study is to evaluate the antidepressant and anxiolytic effects of MCEO on chronic immobilization stress (CIS)-induced mice.Eight groups of male Swiss albino mice were divided into control, CIS+DMSO, CIS+amitriptyline and CIS+MCEO at different concentrations (1, 2.5, 5, 7.5 and 10% v/v). All mice groups except the control were subjected to a 2-hours CIS procedure for 15 days. All MCEO treatments were administered through the inhalation route, while the amitriptyline was via intraperitoneal from day 16 to 20. The anxiolyticandantidepressant effects of MCEO were evaluated via behavioural tests, histopathological changes and corticotrophin-releasing hormone (CRH) level on day 21. Results were analysed using one-way ANOVA followed by Dunnet’s posthoc test with the significant level of P<0> https://jmp...

  The public health concern is very important for the growing burden of chronic metabolic disease like Diabetes mellitus. It is foreseeable that by 2045 India would reach rank first in Type-2 Diabetes Mellitus which contributes to 90% of diabetes. Therefore, more care or attention should be given to this disease. There are so many medications available in the market including herbal drugs. But due to more side effects of oral hypoglycemic agents, attention grabs more towards the alternative of synthetic drugs or using Nano-carriers to avoid side effects. Presently, many novel drug delivery systems for oral hypoglycemic agents are available in the market. But herbal drugs grab more attention due to lesser side effects, efficacy and cost-effective. However, there is very less work is reported on nanotechnology like liposomes, nanoparticles/microparticles, gold nanoparticles, noisome, and nano-capsules/microcapsules of herbal drugs, which is currently emerging therapy for diabetes. Na...

  In South Asia, cattle are afflicted by the expanding virulent condition known as Lumpy Skin Disease (LSD), and sheep pox and goat pox are caused by the Capri virus. These illnesses endanger worldwide trade. Due to inadequate immunisations and poverty in rural areas, Capricorn poxviruses are spreading. This is due to the economic repercussions of the COVID-19 epidemic, debilitating sanctions in endemic countries, a growth in the legal and criminal trade of live animals and animal products, and global climate change. Skin spores are the main route of infection; however, the virus is also excreted through bodily fluids and semen. As a result, the virus is transmitted to susceptible hosts by biting flies, mosquitoes, and other insects. Insects can be transstadial and transovarial. Lumpy skin disease lesions can swell and rupture after 7 to 14 days in experimental settings, but it usually takes 2 to 5 weeks in a normal infection. Lumpy skin disease is characterised by hard, constricti...

  It was in Uganda that the Zika virus was discovered for the first time in 1947. Later in 1952, researchers isolated an infectious agent from rhesus monkeys. 60 years later, in 2007, the first outbreak of Zika virus happened in Brazil. Afterwards cases of infection were reported from Tanzania, Egypt, South Asia, India, Bangladesh, Pakistan, Vietnam, Indonesia, Thailand, Malaysia, Philippines. The most common reason for infection was travelling to infected regions. The main concern in this infection is microcephaly in new born babies and foetuses. In 2016, the first outbreak of Zika virus infection occurred in India, the first three cases were discovered in Gujarat and later one case was found in Tamil Nadu. After two years in two Indian states another outbreak was reported in Rajasthan and Madhya Pradesh with 153 and 130 cases, respectively. Infection spreads due to Aedes aegypti mosquito bites or sexual transmission. Zika virus symptoms include mild fever, rash, joint pain and co...

  The synthesis of Nanoparticle using plant extracts considered as clean and environmentally accepted “green chemistry” concept. The utilization of zinc nanoparticle in the field of agriculture as growth promoting agent were not adequately studied. The present study was intended to synthesise the zinc nanoparticle using aqueous extracts of Schrebera swietenioides Roxb., and the synthesized nanoparticle was evaluated for its applications in the field of agriculture and removal of pollutants in water.The zinc oxide nanoparticles were synthesised using aqueous leaf extract of S. swietenioides and 0.1 M zinc acetate. The formation nanoparticle were identified by observing the colour change of the reaction mixture. The formed nanoparticle was collected by centrifugation followed by washing several times with distilled water and then drying of the particles in air oven. The nanoparticle was characterized using various characterization techniques such as UV spectra ,SEM, and FT-IR. The ap...

  During the COVID-19 pandemic, nurses working in the clinical sector encountered a variety of challenges related to increased stress, which had an influence on the nurses' ability to provide care for patients. The Aim of study was to determine the impact of COVID-19 pandemic on emergency nurses’ stress at the emergency department of King Salman Specialist Hospital in Hail, Saudi Arabia. A descriptive research design was utilized. Subjects included all available nurses who were working in the previous setting. The Instruments used in data collection consisted of the socio demographic data sheet of the studied nurses, the Perceived stress scale (PSS), and the nurses’ pandemic-related experiences questionnaire (PREQ). The results revealed that, the studied nurses had experienced moderate stress regarding the PSS with total mean scores around “2” out of “4”. There was a significant statistical difference in the total mean scores of nurses’ PREQ as regards to work status. The study con...

  Pyrrole is privileged and active heterocycle with diverse pharmacological activities that specifically serve as a promising scaffold for antiinflammatory, antimalarial, antimicrobial, antiviral, antitubercular, and enzyme-inhibiting drugs. In an attempt to explore this scaffold, a series of 2-amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3-carbonitrilewere synthesized and screened for anti-inflammatory activity. The structures of synthesized novel compounds were characterized by 1H Nuclear Magnetic Resonance, Mass and Fourier Transfer Infrared spectroscopic data. All the compounds are screened for anti-inflammatory activity using the rat paw edema method. Among all, compound 1e exhibited more potent activity than the standard drug etoricoxib with the highest inhibition in paw edema at 3 hours and 5 hours. https://jmpas.com/abstract/1128

  Tuberculosis, a major contagious air-borne disease, killing millions in a year. Many of the existing anti-tubercular drugs have acquired bacterial resistance. Though they are highly bactericidal but, later on due to several factors like poor patient compliance, incomplete therapy, etc. leading to treatment relapse. This enables researcher to focus on identifying new leads utilizing structure-based drug design which plays a crucial role in drug development. The mycolic acid synthesized by Pks 13 is identified as a perfect target and hence a series of molecules were designed and the best fit ligands with a least energy were picked and analysed for Insilco bioactivity and drug likeness. Five best docked Molecules satisfied the Lipinski rule of five, namely the number of hydrogen bond donors, acceptors, log P, total polar surface area and the number of rotatable bonds. The bioactivity was found to be moderate to excellent against the receptor. The target molecules were synthesised vi...

  Terbinafine hydrochloride is an antifungal drug belonging to the class of allylamines. The drug exhibits poor aqueous solubility and thus results in decrease in oral bioavailability. In the present study, an attempt was made to enhance the solubility of terbinafine hydrochloride using hydrotropic solubilization technique employing different hydrotropesnamely sodium benzoate and ureain different proportions and their combinations. The different hydrotropes were selected based on the saturation solubility exhibited by the drug. Among them best batches of the drug-hydrotrope combinations of varying concentrations of 5% w/v, 10% w/v and 15% w/v were further subjected for the in vitro dissolution studies and solid-state characterization studies. The results so obtained were an indicative of solubility enhancement of terbinafine hydrochloride in combination of 10% urea, and combinationhydrotropes of 10% urea and 15% sodium benzoate. Thus, the experimental investigation concluded that t...

  Ciclopirox is an anti-mycotic drug, used topically, that belongs to the hydroxypyridone molecular class and is not linked to azole drugs or other anti-fungal medication. Ciclopirox was first designed to treat vaginal candidiasis and fungal skin infections, and it is now widely used for these conditions. Drug repurposing is a method for discovering new applications for authorized or experimental medicines that go beyond the original medical indication. Ciclopirox received acknowledgement as repurposed anti-cancer agent (anti-bladder cancer, anti-Ewing sarcoma, anti-pancreatic cancer, hematologic malignancy inhibitor, proliferating cell lines inhibitor, etc.) owing to multiple therapeutic excellencies, where numerous signaling pathways plays role in treating diverse cancer forms. This review article paved a new way by eventually opening newer possibilities for the enthusiastic (medicinal)-chemists,pharmacologists, and researchers of allied branches to design better drugs, repurpose...

  The fatty liver disease (FLD) considered as major health problem worldwide but its prevalence related to occupation and lifestyle habits is seldom assessed. This research study was conduct to find out the occurrence of FLD among occupation and associated metabolic changes.In this hospital-based study total 328 patients were enrolled. The anthropometric measurement, radiological & clinical examination and biochemical estimation were carried out in all enrolled subjects. On the basis of abdominal sonography; the patients were categorized into three groups such as Normal (without liver disease), non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD). For comparison of continuous variables, analysis of variance (ANOVA) was used to compare the means of study groups. A p-value <0·05 was considered as statistically significant. Mean BMI of NAFLD, AFLD and Normal subjects were 25.39±0.38, 20.13±0.3 and 19.47±0.25 respectively. AFLD group were found sign...

  Duplex kidneys are one of the commonest congenital malformations of the urogenital system that one comes across in urological practice. It can be complete or incomplete. Ureteral duplication is usually asymptomatic but can accompany by urinary infections, ureterocele, vesicoureteral reflux or other congenital complications. The presence of stone in one of the systems may sometimes pose a therapeutic challenge to the urologists, especially when they attempt to remove the ureteric stone endoscopically. We report a 33-year-female who presented with acute left ureteric colic. Axial imaging revealed a large distal ureteric calculus. During ureteroscopy, no calculi were seen in the entire course of ureter upto renal pelvis. Screening with an image intensifier revealed a stone adjacent to the line of ureteroscope, raising suspicion of a duplex system or radio-opaque shadow outside the lumen of ureter. On further evaluation, a mucosal elevation with oedema was seen above and lateral to t...

  Combination therapy of Montelukast (MNK) and Ebastine (EBA) provide anti-asthmatic effector the maintain treatment of asthma and relieve symptoms of allergies. The objective of this study is development of a new simple, accurate, sensitive, and reproducible RP-HPLC method for simultaneous estimation of MNK and EBA in pharmaceutical formulation (tablet) using Ofloxacin (OFL) as an internal standard and validate the same as per ICH guidelines. The chromatogram separation was achieved on Qualisil-5 BDS C8 column (250 mm × 4.6 mm, 5μm) column with mobile phase acetonitrile: water (pH 2.8 with TFA) in the composition of 84:16 v/v at a flow rate of 1 mL/min using PDA detector at 254 nm at ambient column temperature, keeping the injection volume 20 μL. The retention time of OFL, MNK, and EBA was observed to be 2.107 min, 2.517 min, and 3.819 min, respectively. All the criteria for the validation (linearity, accuracy, precision, and robustness) were observed to be within the acceptation ...

  Postpartum depression is a mental disorder which affects most of the adult women with major depressive symptoms. Increased thyroid profile levels and postpartum depression symptoms can effect on mother’s and child’s health. The aim of this study is to test whether there is arelationship between thyroid profile levels and postpartum depression.The design of this study is Correlational observational.A total of 200 patients having either one or two children with previous normal vaginal deliveries, attending the Obstetrics and Gynaecology (OBG) outpatient department between 30 to36 weeks were screened and 28 subjects selected for the study after satisfying inclusion criteria from the University Hospital. A written consent was taken from all the subjects before recruitment. The demographic data of all subjects such as age, period of gestation (POG), hemoglobin, thyroid profile and vitals were recorded at the time of recruitment. The Thyroid profile was checked at the time of recruitme...

The most common primary central nervous system (CNS) tumor originating from glial cells is Glioma. It accounts for approximately 80% of all primary malignant brain tumors. Our aim was to study the expressionof Epidermal Growth Factor Receptors (EGFR) and p53 by Immunohistochemistry (IHC) in Gliomas and to correlate with various histological types and grades as well as clinical parameters like age and gender of patients. It was an ambispective study for 1year and 2 months conducted in IMS Sum Hospital, Bhubaneswar. 38 cases of Gliomas operated in Neurosurgery Department were studied. Histological typing & grading were done according to WHO 2016 classification of CNS tumors. EGFR & p53 study was done by immunohistochemistry (IHC).Out of 38 cases, 14 cases (36.8%), 6 cases (15.7%), 6 cases (15.7%), 4 cases (10.5%), 6 cases (15.7%) and 2 cases (5.2%) were Astrocytoma, Oligodendroglioma, Glioblastoma, GBM with oligodendroglioma, Gliosarcoma and Ependymoma respectively. 2 cases (5.2%...

  Background and Purpose finding out why people choose to engage in mindfulness-based practises can help in the development of effective health promotion outreach efforts. The impact of health attitudes and perceived stress on the intention to practise mindfulness meditation among undergraduate college students in Uttarakhand was studied in this study. Experimental Approach the research is descriptive in nature based upon primary data. A total of 15 aspects have been studied to assess the impact of meditation on mental & emotional state, physical & psychological wellbeing and academic performance of students. For collection of data, convenience sampling technique has been used. Data has been collected via mail survey using questionnaire technique. Descriptive analysis has been conducted to fulfil the objective of the study, where SPSS version 21 was used for data analysis. Key results indicate that meditation has a positive impact on improving mental & emotional state o...

  Severe periodontal disease, which may result in tooth loss, was estimated to be the 11th most prevalent disease globally. Despite such high prevalence awareness regarding it is still very little. Understanding of health seeking behaviour is essential to provide need based health care services to the population and managing periodontal diseases. Hence the present research was carried out to identify the determinants of health seeking behaviour in patients visiting private dental college and hospital with severe periodontitis. A cross sectional study was conducted among the patients visiting private dental colleges and hospitals with severe periodontitis between the age group of 18 and above. Data was recorded by a self- administered, structured, pre-tested questionnaire based on items to determine health seeking behaviour of participants in this study. Study included 512 participants, 279 (54.5%) males and 233 (45.5%) females. It was observed that mobile tooth was the most common ...

  Fucoidan, a sulfated polysaccharide is a well known active principle of marine brown algae, extensively used in food supplement and in pharmaceutical industry. The present study is aimed at evaluation of toxicological profile of fucoidan, isolated from Turbinaria conoides (J.Agardh) Kutzing in both male and female Wistar albino rats. Fucoidan was isolated and studied for Fourier Transform-Infrared spectroscopic analysis to confirm the functional groups. Acute and sub-acute toxicity studies were carried out by Organization for Economic Cooperation and Development guidelines 423 and 407. After treatment period all the animals were sacrificed to evaluate hematological and biochemical parameters. The weights of internal organs recorded and histopathological studies performed. Fourier Transform-Infrared spectroscopic analysis confirms the groups that are correlated with the standard. The animals did not show morbidity or mortality in acute toxicity study at single oral administration ...

  A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL) than standard drugs. Compounds 5a and 5e were reported to be most active antimalarial analogue having IC50 value of 0.24-0.49μg/mL. Compounds 5a, 5e and 5f showed shortest mean paralysis time of (25.6±4.56 min, 26.4±4.97 min and 26.8±4.76 min) and mean death time (47.6±8.01min, 45.6±3.04min and 46.6±7.40min), respectively. Compound 5e showed moderate cytotoxicity with IC50 value of 65.4 ag...

  Dihydropyrimidinone/thiones (DHPMs) hold earmarked place in the field of natural and synthetic organic chemistry, because of their therapeutic and pharmacological properties. Synthesis of such biologically important compounds assumes great concern. Objectives The aim of the present work was to synthesize structurally challenging DHPMs through green procedure, evaluated for antibacterial activity and to perform QSAR analysis to attain the structural requirements for the antibacterial activity. The synthesis of dihydropyrimidinone/thiones was accomplished via three-component one-pot cyclocondensation between substituted alkyl/aryl aldehydes, diketone and urea/thiourea in the presence of pine apple juice at room temperature. The structures of the compounds were established by spectral analysis and evaluated for antibacterial activity. Possible correlation between observed biological activity and physicochemical descriptors was studied. Synthesis of DHPMs by pineapple juice as a cata...

  The main objective is to develop and validate the methodology to study the genetic polymorphism of Organic cation transporter (OCT1) rs622342. The Reverse Transcriptase-PCR method for identifying the OCT1 rs622342 genetic polymorphism was developed and validated. This study is a prospective open-label study conducted over a period of six months with 61 South Indian healthy male volunteers. Phenol chloroform method was used for the DNA isolation, which was subjected to PCR for identifying the polymorphism. The method was successfully developed. After the addition of restriction enzyme (PsiI) in the ten samples, none of the samples showed fragmentation, which shows that there is a lack of rs622342 genetic polymorphism in the selected ten samples. https://jmpas.com/abstract/945

  HACCP (Hazard analysis critical control point) is a WHO (World Health Organization) recommended, renowned and widely practiced control tool towards food safety to counter the possibilities of FBD (food borne diseases) be it chemical or biological in food handling areas. Experimental Approach the study embarks upon the identification and controlling the possibilities of food contamination in each and every step even before it may occur. In the modern scenario, guests visiting the hotels are health and hygiene conscious and are also equipped with latest knowledge. Apart from that, Government with its rules and regulations is highly attentive towards public health. The study suggests that adherence to HACCP procedures helps in establishing maintain better hygiene leading to better rapport between the service providers and the customers. Methods this paper is an attempt to find out HACCP practical implications and its effect on operations of food production areas of 12 five-star cate...

  Corona Virus-19 had a detrimental effect on people's ability to live a healthy and active lifestyle. Social life is impacted by this outbreak, resulting in anxiety and psychosomatic illness. The purpose of this study is to determine the effect of social, physical, and psychological factors on perinatal women enrolled in tertiary health care facilities established during the COVID-19 pandemic. At Saifai' tertiary level hospital, a cross-sectional observational study was conducted. A questionnaire calibrated on the Likert scale was administered to 72 inpatient perinatal mothers to assess their levels of anxiety (n=04), social network dependency (n=03), and quality of life (n=02). Physical characteristics were derived from baseline data. Each section's scores were added together. Group C has the highest mean anxiety level, followed by Groups D, A, and B. When compared using one-way ANOVA, the results are statistically significant at p<0> https://jmpas.com/abstract/942

  An innovative, straightforward, precise, accurate, reproducible, and efficient simultaneous equation method, or Vierordt's technique, was successfully developed for predicting Miconazole and Neomycin in pharmaceutical Non-Pressurized Topical spray. Miconazole and Neomycin absorbance in 6.8 pH phosphate buffer and in ethanol were established at two wavelengths of 246 nm and 224 nm, respectively. Miconazole and Neomycin spectrum of standard curve showed to be linear in concentrations of 5-12 μg/ml and 2-10 μg/ml, respectively, with correlation coefficients of 0.9988. The LOD along with LOQ for Miconazole were 0.59 μg/ml and 7.385 μg/ml, significantly, whereas the LOD and LOQ for Neomycin were 0.28 μg/ml and 1.493 μg/ml. The precision investigation examined at the percent relative standard deviation, values were confirmed to be within allowable limits. At various levels, the percentage rate of recovery for Miconazole ranged from 0.12 to 0.47 percent and 0.23 to 0.31 percent for Neom...

  The synthesis of a novel family of pyrimidine derivatives has been completed. Infrared–infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectrum data were used to describe these pyrimidine derivatives. All the compounds were evaluated for their in vitro antimicrobial activity against Gram negative strain (Escherichia coli) and Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger) and anticancer potential against Human breast cancer cell line (MCF-7). Results of antimicrobial and anticancer study revealed that compounds (E)-N'-(3-nitrobenzylidene)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (4) and (E)-N'-(3-chlorobenzylidene)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (10) were found to be the most potent antimicrobial and anticancer agents respectively. https://jmpas.com/abstract/923

  Nowadays, one of the most common tumors in the world is colorectal cancer (CRC) which is increasing day by day and attributes to the mortality of many lives around the globe. It is also the second most lethal and third most widespread cancer diagnosis for both males and females. However, numerous inventive treatments had been developed for both primary and advanced colorectal cancer which include surgery, chemotherapy, immunotherapy, and utilizing some of the novel drug delivery systems. In the present review, we have attempted to address several innovative, novel treatment methods, procedures, and targeting strategies employing different polymers and drugs to deliver at colonic region. Also, the present review highlighted the applications of nanocarriers such as carbon nanotubes, gold nanoparticles, dendrimers, liposomes, hydrogels, and phytotomies for the effective treatment of CRC https://jmpas.com/abstract/1125

  Around 5—10% women in their productive age could suffer from endometriosis, a condition where viable endometrial tissue is present outside the uterine cavity. This disease could progress into ovarian cancer and infertility with long-lasting chronic pain. Thus, innovation for safe and efficacious management of this disease is urgent. Exploring the abilities of medicinal plants for endometriosis therapy is quite promising. Of which, Phaleria macrocarpa has been suggested as a strong candidate for the therapy. This review begins with explanations of endometriosis; its aetiology and pathobiology. Thereafter, we present the medicinal properties of P. macrocarpa for being anti-inflammatory, anti-angiogenesis, and anti-proliferation. Results from pre-clinical studies and an ongoing trial of P. macrocarpa as a therapy for endometriosis were also discussed in this review. Future study will explore the activity of this plant extracts against hypoxia inducible factor-1α (HIF-1α), vascular e...

  Embelia ribes is the most widely used plant in numerous Ayurvedic preparations to treat various disorders. The most commonly used plant parts like leaves and fruit are in the Indian traditional system for CNS (Central Nervous System) disease, Anti-bacterial Anthelmintic, and Anti-ulcer activity. The proposed work aimed to optimize different extraction parameters (Part of Crude drug, Solvent and Temperature) to increase the extraction yield of the Embelin from Embelia ribes fruits. Extraction was done by using Chloroform as a solvent, and extraction yield was optimized by using independent variables, such as solvent, drug parts, time and temperature, with the help of the design of expert software. One part of the crude drug kept in 3 parts of Chloroform for 34 mins at 49 oC temperature gives the maximum yield (38.73±1.13%) of Embelin. HPTLC was done by using the mobile phase of Chloroform: Ethyl acetate: Formic acid (5:4:0.5 v/v/v). A single band appeared in the TLC plate exhibiti...

  Drugs are a common reason for kidney injury. Antibiotic like gentamicin which is clinically a highly effective drug, is not preferred by physicians primarily because of the renal damage caused by it. Medication-induced renal injury has an intricate mechanism that includes a multitude of elements together with the innate nature of medications, innate patient characteristics that increase the chances of renal damage, and the pharmacokinetics of the drug. A particular drug can produce varied amount of damage in different individuals, which implies that the risk is not same for all. The reason behind this is that, there are different factors which determine the amount of renal damage that occurs due to drugs. In this article, we have reviewed the various elements linked to drug-induced nephrotoxicity. https://jmpas.com/abstract/1122

  With the rapid development of modern life science, computational Molecular docking has gradually become one of the core disciplines and methods of modern life science research. Computational docking studies the relationship between the structure and pharmacodynamics of biological macromolecules and the interaction between biological macromolecules and ligands. It promotes the development of protein engineering, protein design, and computer-aided drug design with powerful and various docking software in predicting the three-dimensional structure and dynamic characteristics of proteins from protein sequences. Nowadays, this computing power can be provided by the GPU through the use of a general-purpose computing model on GPUs. This article presents two approaches to parallelizing the descriptive algorithms on the GPU to solve the molecular docking problem and then evaluating them in terms of the computation time achieved. The proposed approaches are effective in accelerating molecu...

  Triple-negative breast carcinomas are defined by a lack of expression of the steroid hormone receptors i.e., Estrogen Receptor, Progesterone Receptor, and Human epidermal growth factor Receptor-2. They are characterized by distinct molecular, histological, and clinical features. With higher mortality and early relapse, management of these tumors relies on clinicopathologic prognostic factors. Nottingham's prognostic index is a widely used prognostic tool that integrates three independent prognostic factors, namely tumor size, lymph node status, and histologic grade. It is a sensitive index of clinical aggressiveness in breast carcinomas. This study aims to evaluate morphologic features of Triple negative breast carcinomas and correlate them with Nottingham prognostic index. 22 modified radical mastectomies with triple-negative status were considered for this study. Tumor size, histologic type, grade, node involvement, necrosis, lymphovascular invasion, and Nottingham prognostic i...

  During clinical trials, special populations such as children, pregnant women and elderly are excluded, creating lack of information on safety profile of medicines in these population. The lack of reliable efficacy and safety data often leads to under- or over-dosing in paediatric age groups which make them susceptible to adverse drug reactions (ADRs). This study was aimed to investigate the characteristics of ADR reports and serious ADRs among paediatric population in Malaysia. Descriptive analyses were undertaken for demographic characteristics and severity of the ADRs. Binary logistic regression was performed to identify association between selected variables and ADRs. A total of 3410 paediatric case reports for 6769 ADRs were reported within the 5-year period. Children aged one to 12 years old were the most frequently reported to experience ADRs (n=5488, 81%). Male gender exceeds more than half of the ADR reports (n=3812, 56.3%) and Malay race has the highest ADR reports (n=47...

  One of the most important, globally controllable risk factors for cardiovascular diseases and early mortality is hypertension. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, both of which inhibit the renin-angiotensin system, are becoming more common as initial treatments for the management of hypertension patients with which ramipril and telmisartan being the most frequently used. Telmisartan has the highest affinity for the AT1 receptor of all the ARBs.Ramipril and telmisartan both are found to provide a variety of therapeutic advantages. In this study, a detailed comparative analysis has been done between ramipril and telmisartan regarding their efficacy, safety, monotherapy as well as combination therapy outcome and measures to be taken while considering both drugs. This study focused on which one is more successful in treating hypertension individuals, while also having a superior safety profile and combining the two medications which one is link...

  Currently in the world of medicine doctors use computer technology since the use of it can greatly facilitate their work, currently there are brain aneurysms which is a cerebrovascular disease characterized by a dilation of the arterial wall that can trigger internal bleeding and the detection of this has to be carried out by specialized doctors which are trained for an extensive time of training and purpose of this work is to automate the detection of aneurysms by applying artificial intelligence. https://jmpas.com/abstract/1117

  Biofilms are organized communities of micro-organisms buried firmly on an extra polymeric matrix attached to the living surface. The matrix which is formed surrounding the bacteria makes them tolerant to harsh environmental conditions as well as resistant to antibacterial treatment. The development of biofilms in clinical or hospital settings is the major reason for several infections. They have a negative impact when they are formed on medical devices as it is difficult to eradicate them using disinfectants or antibiotics available. Several in vitro models have been implemented in the last decade to evaluate antimicrobial activity on bacterial biofilms. Although well-established static biofilm methods are available; there is a lack of simple dynamic biofilm models to replicate the clinical settings of biofilm development. In this scenario, considering the importance of this research area, we planned to design laboratory-scale working models to study biofilms. We used Pseudomonas...

  A total of 50 patients were enrolled in the study from October 2021 to April 2022. Total numbers of drugs prescribed were found to be 244 including the anti-psychotics. The total numbers of anti-psychotics prescribed were found to be 160. The ratio of anti-psychotics to the total number of drugs was found to be 65.7%. Antipsychotics were the most used drugs (69.6%) followed by multivitamins (7.37%), following them were proton pump inhibitors (5.73%), they were followed by analgesics (5.32%), following analgesics were cognition enhancers (4.9%), cognition enhancers were followed by mood stabilizers (4.09%), mood stabilizers were followed by anti-hypertensives (3.2%) which in turn were followed by anticholinergics (2.04%) and calcium+ vitamin D3 supplements (1.6%) https://jmpas.com/abstract/1115

  The main issue in India and at a global level that led to antibiotic resistance is misuse, irrational prescribing of antibiotics, and lack of sufficient data on antibiotic resistance at a local,regional, and national level to develop antibiotic policy that guides all healthcare professional while prescribing antibiotics. The present study was carried out for 12 months in a tertiary care teaching hospital in western India to develop an antibiogram and to check antimicrobial resistance trends in the hospital. Out of 500 patients, 53.6% were male and 46.4% were female patients. A total of 17 bacterial species were identified throughout the study with gram-negative species infections being most common in hospitals. Escherichia coli was the most frequently isolated gram-negative species. Ceftriaxone was most prescribed frequently followed by amoxicillin and azithromycin, respectively. In the gram-positive organism, ceftriaxone and amoxicillin resistance rate was 65.35% and 35% respect...

This study aims to evaluate diagnostic reference levels (DRLs) for nuclear medicine (NM) imaging studies in Jordan. The parameters of the current study obtained from different NM modalities conducted for adult patients imaging. The Administrated Activity (AA) of a radioactive substance (MBq) was collected from four hospitals specialized in nuclear medicine imaging at Amman City. According to ICRP recommendation, the established DRLs values obtained based on the 75th percentile of the AA values. The obtained results were compared with several international results. The DRLs' values for Jordan were located within the recommended range. https://jmpas.com/abstract/1113