Journal of Medical Pharmaceutical and Allied Sciences

  Pollution is now the main problem for man and his survival. Waste, which can originate from any source, whether mining, industrial, biological or household, is now on the priority list of all countries? The treatment and disposal of waste is a source of local and central government concern. The methods used to dispose of waste create a new problem for society. Dumping solid waste and burying it underground pollutes the soil and handling liquid waste on the ground or in water both causes pollution. Therefore, the pollution caused by the continuous disposal of wastes underground and in the water is not only harmful to the environment, but also has a negative impact on the health of living organisms. This review aims to highlight the status of several Indian states and cities that are suffering from soil and water pollution. The review will attempt to shows oil and water standards, heavy metal status, seasonal changes in soil and water pollution, contaminated agricultural crops, pol...

  Cancer is a lethal illness, and research into the development of effective anti-cancer medications is ongoing at all hours of the day and night. This is where 1,3,4-oxadiazoles come into play, since they are privileged and authenticated compounds because of their anti-cancer capabilities. In the field of drug development, 1,3,4-oxadiazole entities are characteristic heterocyclic rings with dominant anti-cancer activities. As a result, the primary goal of this article is to review the synthesis and screening of new 1,3,4-oxadiazole powerful derivatives is to determine their anti-cancer, antitumor, and other potential applications in the creation of anti-neoplastic drugs. In this study, the focus is on the 1,3,4-oxadiazole hybrids as well as the most significant bioactivity and potentiality of these anti-cancer compounds. This review article will include references to significant current reviews in the material, as well as a relevant discussion on the general background of anti-can...

  In the present study, we examined the potential biological activities of two marginal weeds, Centella asiatica (L.) Urb and Eichhornia crassipes (Mart.) solms, using various solvents (water, methanol, and ethyl acetate). The ethyl acetate and ethanol crude extracts of Centella asiatica exhibited notable antioxidant activity, as indicated by their DPPH radical scavenging ability, with values of 349.33±3.92 and 348.48±2.96 µg Vitamin C equivalents/0.01 g dry matter, respectively. These extracts effectively inhibited free radicals from DPPH at half maximal effective concentrations (EC50) of 160.46±1.62 and 1,330±25.25 µg/mL, respectively. Furthermore, the ethyl acetate crude extract of E. crassipes (Mart.) solms, demonstrated the highest content of total phenolic compounds, with 185.88 ± 2.31µg GAE/0.01 g dry matter, as determined by the Folin-Ciocalteu colorimetric assay. Additionally, the ethyl acetate extract of E. crassipes (Mart.) solms, displayed potent tyrosinase inhibitory a...

  Many phytochemicals such as tannins, terpenoids and flavonoids are hydrophilic in nature, but have low absorption, because they are unable to cross lipid membranes of cells. It has been proposed to combine phytomedicine to nanotechnology, because nanocarrier can deliver active phytochemical during entire treatment period, directing it to the desired site of action. The main aim of this work is to review Phytochemicals which possess promising anti-carcinogenic capabilities in a variety of skin cancer cell lines, animal models and their mechanism of action. The commercial formulations for skin cancer prevention and therapy that are now on the market that is derived from plants are also covered in this review. This paper focused on the recent assessment of the biological obstacles to topical applications of phytoconstituents and also focuses on review of the enormous potential for bioactive phytochemical distribution via developing nanotechnology. https://jmpas.com/abstract/1173

  Apple, (Malus domestica, Brokh), is a vital source of phenolic and polyphenolic compounds whose accumulation in the different parts of the fruit depends upon various intrinsic and extrinsic factors. This study aimed to perform a comparative evaluation of phenolics of peels of three red-skinned (“Delicious”, “Maharaji”, “Royal delicious”), and one yellow-skinned (“Golden Delicious”) apple varieties incorporating preliminary secondary metabolite perusal followed by estimation of Total phenol and total flavonoid contents. Secondary phytocompounds being usually polar in nature were extracted from peels via the Soxhlet and hot maceration processes using different menstruum systems of varied polarity. Comparative assessment of Free radical scavenging, anti-pigmentation, and anti-inflammatory properties of all the decoctures was analyzed thereafter.Free radical scavenging capacity was analyzed via 2, 2-diphenyl-1-picrylhydrazyl assay.Tyrosinase inhibitory activity was assessed by studyi...

  Acanthus ilicifolius is an emergent aquatic plant with potential in environmental phytotechnology. The concept of phytotechnology focuses on the role of plants as a natural technology to solve environmental problems. The plant is an herb used in traditional medicine to cure illnesses ranging from skin problems to snake bites. It contains various phytochemicals, including alkaloids and glucosides, such as lignan and phenylethanoid. Therefore, this study aims to map Achantus ilicifolius extract using the bibliometric method. A bibliometric investigation was adopted through metadata planning with the keywords “Acanthus ilicifolius AND extract” from Scopus Database (1997-2021). Metadata is stored in CSV and BibTex types. Furthermore, CSV format of Scopus metadata for analysis using the counting method on VOS viewer and R-Package with a maximum number of 25 documents. Mapping results showed that the number of publications related to the Acanthus ilicifolius extract experienced a fluct...