Journal of Medical Pharmaceutical and Allied Sciences

 Archaeosomes, or liposomes produced with one or more Archaeobacteria-specific ether lipids, are a novel kind of liposome found in Archaea. The fundamental structures of Achaean-type lipids are archaeol (diether) and/or caldarchaeol (tetraether). To make archaeosomes at any temperature in the physiological range or lower which enable thermally stable compounds to be encapsulated, traditional procedures like hydrated film sonicated, extrusion, and detergent dialysis are used. A multitude of physiological and environmental factors impact its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery, and administration of natural antioxidant compounds. The major purpose of this study was to look at how this unique carrier technology may be used in the pharmaceutical industry SOURCE : Ajay G Pise, Shilpa A Pise, 2022. Archaeosomes for both cellbased delivery applications and drug-bas...

 Dendritic cells, the potent antigen presenting cells, originate from the bone marrow cells and are mostly seen in the lymphoid organs of the human body. Their main purpose is to induct T-helper immune responses whenever they come across an antigenic stimulus. The presence of dendritic cells in the human cervix evoked interest in many researchers to assess their locations, distribution in cervix and to analyze their actual contribution to host immune system. In our present study, we have analyzed the actual distribution of CD1a positive dendritic cells in the benign, premalignant and malignant lesions of the human cervix. This prospective analysis was done on cervical tissue taken from hysterectomy specimens or from cervical punch biopsies. A total of 30 specimens were included in the study. The number and distribution of the dendritic cells in each of the specimens per high power field was calculated. Bleeding per vaginum was the most common presentation. Chronic non-specific cerv...

 Drug administration via oral route is most suitable for drug delivery to patients. But this route is associated with several drawbacks such as high frequency of administration as well as gastric discomfort. To avoid these problems attempt was made to develop the sustained release system by using nanocomposite clay (MMT) and polymer (Na-Al) based microbeads for oral administration of CFR. The formulations were optimized and validated by using Box–Behnken design with 3 different levels of MMT, Na-Al and CaCl2 wherein the %EE and % drug release at 8 h were considered as dependent responses. The developed formulation was characterized by FT-IR, DSC as well as XRD. The optimized formulation was evaluated for % yield, swelling behavior, particle size, drug release and surface morphology by FESEM. The developed formulation showed physical interaction due to surface adsorption and intercalation of drug with that of MMT. The optimized formulation showed high yield, %EE and swelling behavio...

 One of the family i.e. Celastraceae, consists of around 90-100 genera and 1300-1350 species of vines, shrubs, herbs and small trees. It is commonly reported and found mainly in tropical regions. According to this family, scientists reported various species which showed various medicinal uses or properties and these are already described or mentioned in folk/traditional type of medicine. Most of the bioactive derived compounds from this family have been reported or described in the literature as well. In this study, we focused on traditional medicinal plant i.e. Gymnosporia montana of Celastraceae family and studied its phytochemical analysis in leaf extract using different solvent system i.e. aqueous, methanol and ethyl acetate and also analysing it’s in vitro anti-inflammatory and antimicrobial activity. The results showed there is slight variation in phytochemical analysis of leaf extract and showed in vitro anti-inflammatory and antimicrobial activities at higher doses. Overall...

Disasters have an extraordinary capacity to highlight vulnerabilities in systems structures, processes, and people, resulting in significant losses, and hospitals are no exception to this. Recent disasters have demonstrated that hospitals' operational resilience, as well as their structural resilience, must be addressed. Hospital preparedness is an integral part of effective mass casualty management in case of emergency situation arising out of a disaster. This review aims at finding qualitative data regarding an emergency plan that is suitable for a hospital with more than 200 beds. All the major medical databases were searched with relevant keywords and articles published between March 2005 and January 2020 were reviewed and 39 were selected for qualitative synthesis following PRISMA guidelines. Most of the information contained in the reviewed literature shows that a preparedness is related to architectural or design considerations and should be considered while building a new f...

The current study addresses the issues and challenges faced by industry and regulators from early planning for CP development to facilitate time to market with patient-centric solutions and commendations. Global CP regulations are evolving, and a literature study noted ambiguous definitions, inconsistent designations, filing requirements, and little uniformity in the application and assessment of registration processes. The online study was conducted from June 2021 to August 2021 to understand industry challenges around different regulatory world of drugs and devices. The questionnaire was prepared via primary and secondary research having 20 imperative questions/comments that were given to participants after explaining the purpose of the study. Since the questionnaire was broad and cannot cover everything in one research paper, it was decided to split the outcomes in into two parts on Combination products (CP’s) i.e. (i) 10 questions - To understand globally basic understanding & ...

The current study addresses the issues and challenges faced by industry and regulators from early planning for CP development to facilitate time to market with patient-centric solutions and commendations. Global CP regulations are evolving, and a literature study noted ambiguous definitions, inconsistent designations, filing requirements, and little uniformity in the application and assessment of registration processes. The online study was conducted from June 2021 to August 2021 to understand industry challenges around different regulatory world of drugs and devices. The questionnaire was prepared via primary and secondary research having 20 imperative questions/comments that were given to participants after explaining the purpose of the study. Since the questionnaire was broad and cannot cover everything in one research paper, it was decided to split the outcomes in into two parts on Combination products (CP’s) i.e. (i) 10 questions - To understand globally basic understanding & ...

Stroke is a neurological condition that causes damage to the brain tissue caused by the cutoff of normal blood flow due to vessel collapse or thrombosis. Depending on the areas affected, size, and the cause of injury, motor, sense, recognition, language, and perception deficits are common symptoms of the disease. Patients with stroke often presents with problems such as weakness, spasticity and impaired movement patterns along with decreased balance and mobility issues. There are many physiotherapeutic approaches focussing on early recovery of stroke patients. One approach which can be primarily used to improve strength when there are visible voluntary individual movement patterns is Proprioceptive Neuromuscular Facilitation techniques. The present case report is of a 50-year-old male with left hemiplegia who underwent physiotherapy for 4 weeks primarily emphasizing on strength through Proprioceptive Neuromuscular Facilitation. After 4 weeks there was improved strength in left upper an...

In literature, medicinal plants including fruits and vegetables may be considered as one of the better available sources of natural antioxidants. In view of this, we evaluated the antioxidant and anti-inflammatory activity of Cucumis sativus (vegetable) and Citrus sinensis (fruit). In this study, we tested different concentration of peel aqueous extract against 2,2-diphenyl-1-picrylhydrazyl. (DPPH) for measuring its antioxidant activity and evaluated its anti-inflammatory activity against Bovine serum albumin (BSA) and also analyzing its hemolytic activity. The results of these studies which showed that aqueous peel extract of Cucumis sativus and Citrus sinensis at higher doses showed dose dependent effect as compared to control. Hence, further investigation is required particularly in the potential discovery of active natural bioactive products from fruits and vegetables SOURCE : Kamboj Vaishali, Kamboj Abhilasha, Kumar Vijay, Gupta Amit, 2022. Exploration its antioxidant and anti...

The increasing applications of nanoparticles such as Silicon dioxide nanoparticles (SiO2 nanoparticles) are found in the various biotechnological and biomedical fields like drug delivery, disease diagnostics, imaging, biosensor development, cosmetics, foods, etc. In the new era of nanotechnology, we get new dimensions in medical and pharmaceutical fields such as vaccine design (as nano materials show good performances in antigen delivery, as it mimics viral body and also it acts as adjuvant). Thus, a systematic and mechanistic evaluation of the possible biotic and toxic effects of SiO2 nanoparticles needs to be tested for their safe applicability in human life. In the era of multiple drug resistance and the simultaneous outbreak of new bacterial, viral and other zoonotic strains, human beneficial gut bacteria play a major role in developing the body’s immunity. It controls mucosa-associated immune cells and produces a large number of antibodies. Thus, probiotic treatment becomes crucia...

Tobacco use is a leading cause of chronic diseases in India. It kills almost 1.3 million people every year. The country is the second largest producer and consumer of cigarettes. The use of tobacco is very easy to start and is available at very low prices. One of the biggest threats to public health is tobacco use. It leads to the deaths of thousands of people and has a heavy social and economic cost. There are around 267 million tobacco users in India. The most common type of tobacco used by Indians is smokeless tobacco. Khaini, which is a tobacco mixture used by almost every ninth adult, is followed by bidi smoking and gutkha tobacco. According to the Global Adult tobacco Survey, around 11% of Indian adults smoke cigarettes. This is a community-based study involving 626 patients having Immature cataracts with H/O chronic tobacco use from rural population of central Uttar Pradesh in North India coming from low Socio-economic strata with no major Ocular pathology who underwent Cataract...

Present work involves the development of novel in situ film-forming hydrogels (FFH) consisting of primarily Carbopol 934P, HPMC E50 LV and PEG 400. Here, propylene glycol was employed as a permeation enhancer for studying its effect in the formation of FFH and drug permeation. Prepared formulations were assessed for various parameters. Prepared FFH was uniform in weight and thickness with acceptable pH, viscosity and spreadability. Prepared FFH was able to form the in- situ film on the skin surface within 7min. propylene glycol was found to have a direct relationship with moisture content, moisture uptake and water vapour transmission. Higher drug encapsulation and better permeation were also observed when concentration of propylene glycol was increased. All formulations were non-irritating to the skin and thus acceptable. In conclusion, prepared in-situ film-forming hydrogel can be effectively used as a novel dermal drug delivery system SOURCE : Nidhi Dobhal, Jyotsana Bhatt, Bhuwa...

Shoulder flexion, abduction, and external rotation at 90 degrees of abduction are affected after breast cancer surgery. Rehabilitation is often customised to the individual needs of every patient. Not every patient experiences the same rehabilitation, and as such, physiotherapists are able to support patients with a variety of symptoms. When selecting a type of procedure, duration, location and the type of mastectomy are essential considerations. Exercises can be recommended as early as 24 hours after surgery to maintain the shoulder range of motion and arm mobility. In restoring strength and promoting good circulation, these exercises are important. These activities can be changed to achieve new objectives as recovery progresses. In previous years, the preferred treatment for allstages of breast cancer was complete removal of the breast or radical mastectomy. Currently, various forms of mastectomy are tactically performed on the patient, based on age, menopausal status, cancer stage, ...

Stress word itself causes stress for many. It is a state of mental or emotional strain. Infertility also similarly creates stress in the mind of the person suffering from it. Interestingly Stress also lead to Infertility, by altering the hormonal milieu of an individual. Treatment of infertility therefore requires interventions to reduce Stress. Diagnosing and quantifying this stress is very important. Stress reduction requires a multimodality approach. It should include pharmacological, non-pharmacological, behavioral, psychological, social, lifestyle, educational and mind-body interventions or strategies. These various approaches to reduce stress and manage infertility needs a structured clinical testing and trials. Once these interventions are routinely included in all clinics and hospitals managing infertility, their effects could be better studied. The purpose of this review is to inculcate this multimodality approach in each and every heath care provider who is involved in managi...

Interprofessional education (IPE) is preparing health professions students to work as a team in a collaborative environment to provide holistic patient care. The objective of this study was to measure the preparedness of faculty and undergraduate health professions students toward Interprofessional education and to evaluate the Interprofessional teaching module delivered by IPTBL pedagogy. A quantitative Pretest-Posttest experimental study design was adopted using homogeneous convenience sampling. An IPE program was developed by IP Team which had three phases, first to measure the Readiness for Interprofessional Learning using (RIPLS) questionnaire, and second, to develop a Learning module for noncommunicable disease (Acute coronary syndrome), and the third Implementation of the module using IPTBL pedagogy. Seventy-eight participants volunteered for this IPE program, out of which 48 undergraduate health professions students from medicine and nursing programs and 30 faculties working in...

The current circumstances have led towards a consideration to keep proper hygiene and sanitation in hotels kitchen during Covid-19 pandemic to prevent from food contamination. This study aims to assess need analysis on maintaining the level of hygiene and sanitation in hotels kitchen amid Covid-19 outbreak. Food handlers should be aware about the necessary to improve the hygiene practices. Proper utilization of disinfectants and chemicals with utmost care is very necessary to maintain hygiene and sanitation. This paper is aims to assess need analysis on maintaining the level of hygiene and sanitation in hotels kitchen amid Covid-19 outbreak. The current circumstances have led towards a consideration to keep proper hygiene and sanitation in hotels kitchen during Covid-19 pandemic to prevent from food contamination. Data was collected through a survey during the lockdown period from the professionals hailing from Food and Beverage Production and Service departments of renowned hotels. Th...

Metagenomics is the combination of genomics branch and meta that means huge set of genomes from different organisms. Metagenomics is also called as environmental genomics or community metagenomics it is the field to study microbial community in the natural sample like soil, ocean, river, plants, animals, humans etc. With the advent of next generation sequencing techniques and capability of high-end sophisticated software and tools it is possible to analysed mixed population of genomes. Metagenomics has enabled researchers to study microbes and their interaction within themselves and environment to explore microbe interaction and functions. This approach of studying microbiome in any natural samples or biological samples has tremendous application in research like agriculture, animal breeding, textile, industry, clinical and medicine, food and beverages, drug discovery etc. Relationship between a human being and their microbiome is a mutualistic symbiosis. It aids in immune system devel...

Spinal Tuberculosis (TB) is also known as a disorder that typically leads to a progressive onset of neurological deficits. The anterior part of the vertebral body adjacent to the subchondral plate is the usual involvement site which occurs most often in the lower thoracic vertebrae. Vertebral collapse is a potential consequence of this disease and if this happens anteriorly, anterior wedging results, leading to kyphotic spine deformity. The present case report is of a 30-year-old male diagnosed with Potts spine, presented with neurological deficits and pain. He underwent 4 weeks of physiotherapy primarily focussing on lower limb functional activities. He was under medical management for same. After 4 weeks patient showed good clinical response towards therapy and there was a significant improvement in his range, strength and transitions involving lower limbs. Through this case report we want to conclude that medical and physiotherapy management should go on hand in hand to gain optimal...

Spinal Tuberculosis (TB) is also known as a disorder that typically leads to a progressive onset of neurological deficits. The anterior part of the vertebral body adjacent to the subchondral plate is the usual involvement site which occurs most often in the lower thoracic vertebrae. Vertebral collapse is a potential consequence of this disease and if this happens anteriorly, anterior wedging results, leading to kyphotic spine deformity. The present case report is of a 30-year-old male diagnosed with Potts spine, presented with neurological deficits and pain. He underwent 4 weeks of physiotherapy primarily focussing on lower limb functional activities. He was under medical management for same. After 4 weeks patient showed good clinical response towards therapy and there was a significant improvement in his range, strength and transitions involving lower limbs. Through this case report we want to conclude that medical and physiotherapy management should go on hand in hand to gain optimal...

Pre-eclampsia is a pregnancy disease that affects many systemsin women who were previously normotensive and develop high blood pressure after 20 weeks of pregnancy. This study aims to see if serum anti-malaria hormone levels between 11 and 14 weeks of pregnancy have any link to preeclampsia, and if so, what function it plays in the pathogenesis and prevention of preeclampsia and subsequent cardiovascular abnormalities later in life. This study will be conducted on 350 antenatal women who will be subjected for serum anti-malarial hormone (AMH). Women with altered values will be divided into two groups and will be followed till 7 days postpartum for development of pre-eclampsia and pregnancy outcome. Various studies have been carried out in developed countries have proven the association between AMH and preeclampsia but also the long-term effect on the cardiovascular system. This study will emphasize the role of AMH in a developing country like India where the burden of pre-eclampsia is ...

The novel Coronavirus Disease (COVID-19) pandemic has affected all the parts of the world. India has seen two peaks in the first and second waves, and currently in second place globally after USA. The peak in the first wave was observed in the mid of September, 2020 and in the second wave, the peak is said to be crossed during early May, 2021. Although India is visualizing declining trend and crossed peak on 20th January 2022, many research studies and scientists are still recommending not to lower guard due to possibility of new variants. Proper modelling of COVID-19 distribution may help in determining the course of pandemic and planning the future requirements. The purpose of this study is to analyse the COVID-19 data in India using various probabilistic distributions and identify the best fit model. Further, regression analysis is also carried out to predict the relation among variables like daily cases, deaths, number of people vaccinated and reproduction rate. The effect of curre...

Recently , photobiomodulation has been shown to positively modulate the properties of dental pulp stem cells (DPSCs) in regenerative endodontics which is considered a promising solution to standard therapies for preserving pulp vitality and avoiding more extensive treatments such as endodontic therapy and tooth extraction. Therefore, the present study evaluated the effects of photobiomodulation and exsosomes of DPSCs for pulp regeneration in dogs . Five healthy mature mongrel dogs were divided into four groups ;group I, negative control; group II; Positive control(exposed pulp covered by A sterile piece of polytetrafluoroethylene (PTFE, Teflon tape) , group III: PBM group with 980 nm diode laser with output power 100 mw for one minute , group IV; exosomes, group V: exosomes + PBM.. Each dog represented one group. Blood samples were collected from dogs after 14dayspostoperatively. Biochemicals as total and ionized calcium, phosphorus, and alkaline phosphatase levels and the gene express...

High throughput sequencing technology that are also called as second generation or Next Generation (NGS) sequencing techniques has enabled researchers to study genome, transcriptome, metabolome of any organism in high throughput manner. RNA seq (Ribonucleic Acid Sequencing) is a NGS technique that is used to sequence total transcripts of cell and to study gene expression. This technique is widely used to identify differentially expressed genes and to identify variants. RNAseq technique has been used to study several diseases like cancers, neurological diseases, bacterial infections diseases and to understand the key mechanism of genes and its functions. Melanoma is a threatening tumor and one of the most successive metastatic diseases. Melanomas ordinarily happen inside the skin yet inside the mouth, digestion tracts or eye. Melanoma carcinoma is also called as cutaneous melanoma or melanoma of the skin. In current research Pair end RNA-seq sequencing data for melanoma cell was retriev...

Distal radius and ulnar fractures usually have a significant role in affecting the functions of hand. They are the most common fractures of the forearm caused by either direct trauma (hit by bat) or indirect trauma (fall). Important clinical features are pain, swelling and decreased forearm and hand functions. These fractures are diagnosed by X-rays and usually managed either conservatively if the fragments are not displaced or by open reduction if the fragments are displaced. The present case report is of a female of age 55 years met with an accident 3 weeks prior. She was operated on the next day with open reduction and internal fixation and physiotherapy started immediately the next day. Patient was given early physiotherapy training to fingers and shoulder joint of left side to prevent disuse atrophy and to improve circulation. Along with this the patient was also encouraged to perform gripping activities of affected hand, Thumb movements an also generalised active movements for re...

Celiac Disease (CD) is an immune reaction caused due to intake of gluten protein called gliadin in susceptible individuals. Studies had shown correlation between celiac disease and increase in ROS (Reactive Oxygen Species) in the body which resulted in oxidative stress in people with celiac. Glutathione, a natural antioxidant, present in the body could be regenerated with diet rich in antioxidants. This research aims to alleviate the oxidative stress caused by ingestion of gluten in celiac patients. It focuses on developing plant based antioxidant rich powdered dietary supplement from medicinal plants such as Emblica officinalis, Zingiber officinalis, Curcuma longa, Terminalia chebula, Piper longum, Azadirachta indica and Foeniculum vulgare, that has the ability to reduce the oxidative stress and makeup the nutrients deficiencies in Celiac patients. The Free Radical Scavenging Assay using DPPH (1, 1-Diphenyl-2-picrylhydrazyl) method and protein estimation using Lowry’s method were used...

The WHO claimsthat the disorders of the airways and lungs are known as chronic lung illnesses. Among the most serious are COPD, asthma, pulmonary hypertension, occupational lung disorders, and asthma. Adults with chronic respiratory disease are categorized into two categories: obstructive and restrictive. Reduced lung volumes are a feature of restrictive lung disorders, which can be caused by lung parenchymal alterations. Postural abnormalities are a result of these presenting signs of chronic respiratory disease. It mostly affects the cervical and lumbar regions of the spine, with symptoms such as forward head position and upper thoracic kyphosis caused by the continued usage of accessory breathing muscles. The 6MWT distance is used to assessthe functional capacity of patients. It is a simple way to assessthe status of cardiac and pulmonary diseases. To assess postural deviation and functional capacity of the patients with chronic lung diseases and correlate 6 MWT, Vo2 peak with postu...

Metoprolol succinate is a cardio selective β-blocker used in the management of secondary hypertension complications. Metoprolol succinate is prescribed to suppress the hypertension condition and to minimize the cardiac related disorder. In the present study, metoprolol succinate sustained-release tablets were successfully prepared by the wet granulation method. Carnauba and beeswax as natural resources were used as drug release modifying polymers in varying ratios of 1:0, 0:1, and 1:1 respectively. All developed tablets were passed the uniformity of weight, friability, uniformity of thickness, and uniformity of diameter test respectively. The crushing strength of formulated tablet was in ranges of 1.4 to 2.4megapascal (MPa) and showed the optimum tensile strength. The formulated tablet's percentage of drug content and content of uniformity had97.50 and 99.24.The formulated batch F3 (ratio of 1:0) which are capable for provide the desirable drug release over a twelve hours period. T...

Structures around the cervical spine are a common source of neck pain and have numerous aetiologies. One of the aetiologies considered here is the sustained abnormal posture; this type of presentation can be seen in the population which works tirelessly in the same position for hours like the patient in our case who works as a technician. Patient’s main concerns were pain in right shoulder radiating till the elbow, the severity of the pain kept the patient awake for nights. Clinical findings include severely restricted extension of neck and reduced lateral flexion and rotation of the affected side; Spurling’s test positive for the affected side and distraction test positive. MRI revealed cervical intervertebral disc protrusion at multiple levels (C3-C4, C4-C.5, C5-C6, and C6-C7). This case report concluded that poor cervical posture responsible for overloading on cervical spine leads to disc protrusion in people who work for long hours in abnormal posture   SOURCE : Lakka...

 Physiotherapist plays an important role in prevention of diabetic polyneuropathy (DPN) by planning of exercise protocol and educating about the foot self-care behaviors. Thus, the objective of the study was to determine their interpretation and level of Physiotherapy awareness. Diabetic neuropathy population identified in the community screening camps were included after the final confirmation by the Diabetologist. Patient Interpretation of Neuropathy (PIN) Questionnaire (modified version) was given to the participants. Responses were obtained on the Likert scale. Descriptive statistics was used for finding the mean, percentage & standarddeviation.70%of the participants were uncertain about the causal domain; 74% were uncertain about the duration and course, 64% were uncertain about the physical consequences domain and 50% were uncertain about the controllability domain. Majority had a good interpretation score for nature (70%) and emotional consequences (78%) domain. Higher t...

 RACT Antibiotic resistance is a major threat that associated with deficient in discovery of new antibiotics. Although some countries have been capable to contain resistance, but in most countries antibiotic resistant bacteria prolong to rise with antibiotic consumption in both humans as well as animals. For all decision makers worldwide, the antibiotic resistance is a global issue and a major concern. Some proceedings have been carried out in the last 15 years, in particular by the World Health Organization, the Centre for Diseases Control and Prevention and the European Centre for Diseases Prevention and Control. However those accomplishments were incomplete and poorly implemented, without proper coordination. Our aim in this review is to understand the cause and effectiveness of antimicrobial resistance by putting some lights from evolution of antimicrobial resistance. Like bacteria, different microorganisms have consistently developed so they can oppose the new medications that...

Hydro pneumothorax is a rare variant type of pneumothorax. It occur when both free fluid and air within the pleural space. The goal in treating a hydro pneumothorax is to relieve the pressure on your lung, allowing it to re expand .Treatment options may include observation, needle aspiration, chest tube insertion, non-surgical repair or surgery along with a very important role of physiotherapy. A 54 year male patient came to the hospital with complaint of breathlessness (MMRC grade II), dry cough and high grade fever since one month. The patient had a history of alcohol consumption and tobacco chewing since 10 years. Laboratory investigations showed WBC count 18,600/ml. Complete blood count gave normal results. The arterial blood gases revealed PO2 as 69. Chest X-ray which showed fairly large opacities with fluid level in right side. The costophrenic angle on the right side is obliterated. Multiple, small patchy opacities are also seen in left lower zones. Along with these findings, th...

This study has investigated antiplasmodial activity of extracts, fractions and an isolated compound from corn silk using both in vivo and in vitro assays. Also, safety studies were carried out on the extract. Pharmacologically, both aqueous and methanolic extracts demonstrated remarkable in vivo antiplasmodial activity of 78.9 ± 1.59 % and 77.3 ± 0.92 % reduction in parasitaemia respectively. The bioassay guided fractionation indicated that ethyl acetate fraction of the methanolic extract of corn silk exhibited highest antiplasmodial activity among the fractions investigated. Employing column chromatography and other chromatographic methods on the ethyl acetate fraction of the methanolic extract of corn silk led to isolation of norbergenin. Spectroscopic methods such as infrared, one-dimensional, two-dimensional nuclear magnetic resonance and others were used in characterization and identification of the compound. Antiplasmodial investigation of the compound using in vitro SYBR Green 1...

Traumatic Spinal Cord Injury (SCI) is considered as a major disability and also life-threatening condition that carries a high risk of morbidity and mortality. The objective of this study was to discover the factors affecting social participation restriction in the individuals with SCI. Traumatic SCI patients details were collected from medical records of S.D.M Hospital, 30 patients in total were interviewed face to face with items of CHART-SF in the vernacular language. Responses were obtained and calculated as per the manual scoring for CHART-SF. Descriptive analysis was used for finding mean, median, a standard deviation and the median scores for the main domains of CHART-SF which were, for physical independence 32 which is considered to be moderately handicap, cognitive independence 100 which is not handicap, mobility 14 severe handicap, occupation 13.75. The statistical tests used were Kruskal Wallis ANOVA and Mann-Whitney U test to compare the variables (each domain of CHART-SF) ...

In the present study, we successfully synthesized a series of 4-hydroxycoumarin with a variety of aromatic aldehydes via a one-pot route. The excellent results of this-(4-hydroxycoumarin-3yl) methane derivatives were obtained in the presence of 5.0 mol % DMAP as a catalyst in Ethanol at room temperature using conventional and ultrasonication methodologies. All the synthesized compounds were bioactive. The synthesized bis-coumarin derivatives were evaluated for the antibacterial activity (in-vitro) against the Staphylococcus aureus, and the results were compared with the standard Kanamycin. Molecular docking analysis was revealed that compound 3,3'-((2-chlorophenyl)methylene) bis (4-hydroxy-2H-chromen-2-one (3c) showed good interaction with bacterial cystathionine gamma-lyase MccB of Staphylococcus aureus protein (-6.8 kcal/mol binding free energy). The results confirmed that majority of the as-synthesized compounds revealed splendid antibacterial activity. The compound 3c (Minimum ...

Breast cancer is one of the most common cancer which is prevalent in females worldwide. Mastectomy is a common surgical method used to treat breast cancer. Women may experience many complications post-surgery such as reduced range of motion, pain, lymphedema, shortening of muscles, fatigue and decreased functional capacity which affects the quality of life of the breast cancer survivors. Early physical therapy may benefit the patient in all these aspects. This study aimed to evaluate the effect of Home-based tailor-made protocol in breast cancer survivors. This interventional study was conducted in SDM Hospital, Dharwad, Karnataka. Convenient sampling was done. 40 eligible participants were included in the study. Duration of the study was 6 weeks. The participants were evaluated on EORTC scale for quality of life, SPADI for shoulder function and pain and 6MWT for functional capacity. Baseline evaluation was done on the day of discharge post mastectomy, 2nd visit was done after 4 weeks ...

The ethanol extract of Guava (Psidium Guajava) fruit is known to have strong antioxidant activity so that it has the potential to be developed into a nanoparticle delivery system. The purpose of this study was to determine the effect of variations in the concentration of chitosan - alginate polymer on the physical characteristics of guava fruit extract nanoparticles (Psidium Guajava). Guava Fruit Extract was formulated in the form of nanoparticles by ionic gelation method with variations in the concentration of chitosan:alginate polymer, namely 0.5% : 0.5% (F1), 0.75% : 0.5% (F2), and 1% : 0.5% (F3). The test parameters include the percentage of transmittance. The optimal formulation is based on the level of clarity of the solution and the percentage of transmittance obtained in the formulation ratio of 0.75%: 0.5% (F2), with an average transmittance of 91.9%. Based on the results of the research that has been done, it can be concluded that guava fruit extract can be formulated in nano...

Rehabilitation sometimes may be an uncomfortable and tiring method that incorporates multiple activities and sets of exercises which patients require to perform to achieve good prognosis, for a significant period of time. Unfortunately, most of times the patients frequently become not willing, aggravated, and need inspiration and feel exhausted which makes recovery from the condition will less proficient. Use of the Virtual Reality have been broadly executing into rehabilitation program intends to make the process of recovery more energizing, invigorating and engaging for patients. Within this protocol, we propose to utilization of head wearing gadget name Oculus Quest for patient's wrist recovery after Colle’s fracture. After receiving Institutional Ethical committee approval, we will include 40 Colle’s fracture patients, and randomly divide them in two groups. Further group A will receive conventional physiotherapy treatment and group B will receive treatment from Virtual reality...

The study aimed to compare the effect of Proprioceptive neuromuscular facilitation stretching Vs. Aerobic training on HbA1c levels in patients with type 2 diabetes mellitus. Forty sedentary type 2 diabetes mellitus patients (22 males & 18 females) were randomly allocated in Aerobic Training group(n=20) and Proprioceptive neuromuscular facilitation stretching group(n=20) with twelve-week protocol for both the groups. Glycosylated Hemoglobin (HbA1c) was measured before and after the intervention to examine the effect on blood glucose level. Both Aerobic training and Proprioceptive neuromuscular facilitation stretching induced decrease in blood glucose levels (Glycosylated Hemoglobin HbA1c) after the protocol (P< .001). There was no significant difference between the two groups (P>0.001). This study shows that both Aerobic training and Proprioceptive neuromuscular facilitation stretching reduced blood glucose levels. There is no significant difference between the two interventio...

Post-operative stiffness of knee joint along with neuro-deficit foot drop damage is a complication following open fracture of lower limb. To prevent damage of soft tissue, flap is needed. Lifting of limb is hampered in foot drop, seen in problems such as stroke. Aim of Modified physiotherapy rehabilitation is to help in early sensory and motor reeducation in foot drop secondary to postoperative stiffness. A 19 Year male was diagnosed as compound grade IIIB fracture of tibia fibula and was operated for interlocked nail with skin graft. After 1 week patient was referred to physiotherapy OPD with complaints of pain, restricted range of motion, stiffness, decreased strength adhesion formation and swelling over right leg. Patient was treated 5 days per week for 8 weeks. Modified physiotherapy rehabilitation was given for 8 weeks which include muscle energy technique, electrical stimulation, Maitland’s mobilization, mulligan’s technique. Physical examination and phase wise exercise is descri...

We designed series of pyrazole based Schiff bases on the basis of Bioisosteric replacement principle and validated for drug likeness using Absorption, Distribution, Metabolism, and Excretion (ADMET) criteria. The designed Schiff bases who have excellent pharmacokinetics properties, Low toxicity when In-silico analyzed for inhibition potential using molecular docking study. The top hit of molecular docking having free energy of binding in between -6.95to -4.28 kcal/mol was synthesized and biologically evaluated for fungal biofilm inhibition and minimum inhibitory concentration. The invitro biological assay of synthesized Schiff bases suggesting antibiofilm activity of Schiff base MPY10 inhibitory concentration (IC50=41.7μM) and MPY1 (IC50=44.7μM) very much equivalent to standard drug Fluconazole. The inhibition potential of MPY10 (MIC=42.6μg), MPY1 (MIC=54.4μg), MPY2 (MIC=58.1μg), MPY6 (MIC=61.8μg) and MPY4 (MIC=64.2μg) reproduces the molecular docking results shown against c. albicans ...

India being the second most populated nation, observed the chronic outbreak of Novel Coronavirus as an instrumental factor for bringing about a major shift in the conduct of routine work and regular course of common life during the tragic year of 2020. The virus has given severe jolts to the economy, its distinct classes as well as its citizens alike, projecting far reaching effects across the country and disrupting the ordinary flow of the vital world. With special reference to the middle- class households in India, the purpose of this study is to highlight the impact of COVID-19 on the various facets of mediocre lifestyle including law and order, family and festivals, income and expenditure, mental and physical health, community welfare and social work, creativity and culture, citizen compliance and environmental concern etc. This research intends to provide a useful insight on how the virus is affecting the perspective of mediocre men under the exceptional circumstances of Pandemic ...

Piriformis syndrome, a prevalent cause of low back discomfort around the world, is caused by muscular tightness. By serving as an external rotator, a weak hip abduction, and a weak hip flexor, the piriformis muscle promotes postural stability when walking and standing. Stretching aids in decreasing the stiffness of the Piriformis muscle at rest, as well as the risk of Sciatic compression caused by Piriformis tightness. Reduce discomfort and muscular tightness while increasing range of motion. The experiment will be a randomized trial. A total of 20 persons would be chosen for the study based on the inclusion or exclusion criteria from AVBRH & RNPC, Sawangi Meghe. The study will last six months. Twenty participants were divided into two groups. All groups received an ice pack approximately 10 minutes prior to stretching, and all groups received static stretching. Stretching is done for 30 seconds in group A and 10 seconds in group B. The key outcome measurements for the patient shou...

The entrance of the dengue virus to the host cell is mediated by its main envelope (E) protein. The crystal structure of E protein shows a hydrophobic pocket occupied by the detergent n-octyl-β-D-glucoside (βOG) lying in the Hinge region among domains I&II, which recognizes the hydrophobic ligand, opens and closes via a transition state in the beta-hairpin at the interface between two domains at low pH triggered conformational rearrangement necessary for fusion. We have identified fourteen plants that have been reported for anti-dengue activity. Though these plants are noted for anti-dengue activity, their molecular mechanisms are not fully explored. To know their targets, molecular docking experiments using Command Line Calculator (CLC) Drug Discovery Workbench Software have been performed against dengue virus envelope protein (DENV E) (PDB ID: 1OKE). The Glabranin and Hyperoxide have been showing docking scores (-52.89 and -51.27), nearing the standard n-Octyl-beta-D-glucopyranos...

Plants and herbs have been used as sources of safest compounds in the management of diseases as well as in the restoration and fortification of body structures in ancient medical systems such as Ayurvedic, Unani, and traditional Chinese medicine. The major motive for incorporating herbs in healthcare is to develop a healthy relationship with the body's chemistry while eschewing off-target and unwanted side effects produced by synthetic medications. A surge in the human population, an insufficient supply of drugs, a non-manageable cost of treatments, and a surge in antimicrobial resistance to presently used drugs have forced the pharmacognostic researchers to trace out novel plant-based bioactive compounds to be used as therapeutic agents against innumerous kinds of diseases and disorders. In this study, we include two different samples of Mentha arvensis also known as Pudina or wild mint procured from two different locations in Uttar Pradesh region of India. One sample was taken ne...

A combination of Voglibose and Mitiglinide calcium hydrate is used in Type- 2 diabetes. The method was based on pre-column derivatization of Voglibose with 9-Fluorenylmethyloxycarbonyl chloride due to lack of chromophoric group it cannot directly estimated by UV detector in Reverse Phase High Performance Chromatography (RP-HPLC) method. The chromatographic separation was achieved using phosphate buffer (pH 4.0) and methanol (30:70) as mobile phase. Detection was carried out at 233 nm using UV detector. The retention time of Voglibose and Mitiglinide calcium hydrate were found to be 5.233 min and 3.580 min respectively. The RP-HPLC method for Voglibose and Mitiglinide calcium hydrate was found to be linear over the range of 0.5-1.50 μg/mL and 25-75 μg/mL respectively. Correlation coefficient for Voglibose and Mitiglinide calcium hydrate was found to be 0.998 and 0.999 respectively. Accuracy for Voglibose and Mitiglinide calcium hydrate was 99.79-100.94 % and 100.69-100.88 % respectively...

Newcastle disease virus (family Paramyxoviridae; genus Avulavirus), poultry disease isextensively spread in Asia, Africa, USA and Canada. In literature, strains of Newcastle disease virus are worldwide reported and causing a huge loss to the poultry industries. The present review discusses about Newcastle disease virus and mentioning about its clinical trial-based studies and also discussed about surveillance-based studies and vaccination. In this literature there should be more focus area on the techniques to make a vaccination successful and make any permanent cure for it. Also, we have checked the mortality rate of different states so that we should perform our techniques in those countries. In addition, this literature includes bioinformatics approach study various strains of Newcastle disease virus. https://jmpas.com/abstract/1046

Children with congenital heart disease (CHD) have compromised physiological function compared to normal with the same age and anthropometric measure. Physiologic cost index (PCI) calculated the energy expenditure and gives an idea about the same during walking. So the present observational study calculates the energy expenditure in repaired congenital heart disease patient and provides the baseline for a goal to achieve during any rehabilitation program by comparing with the normal. To compare the PCI between repaired congenital heart disease patients and healthy children. The study design is observational. Total 40 participants were selected as per the criteria for inclusion and exclusion i.e. 20 healthy children and 20 with repaired congenital heart disease. Duration of the study will be for six months. The six-minute walk was performed according to guidelines, and PCI was calculated using the Macgregor’s formula. In all the variables found of 6MWT, statically significant difference ...

The aim of the present work to develop an accurate, simple, sensitive, and validated Ultra violet (UV) spectrophotometric procedure using multilinear regression method for the analysis of Ondansetron in its bulk and commercial dosage form. The multivariate calibration approach was based on equations constructed using linear regression analysis using the correlation between absorbance and concentration at selected five different wavelengths. Ondansetron had a maximum wavelength of 246 nm. The findings were statistically analysed. A linear plot in the concentration range of 5-15 μg/mL, with a regression co-efficient of 0.999 was obtained. The % RSD for intra-day and Inter day precision were 0.0409 and 0.0228, respectively. The assay was determined and found to be 98.38 % – 101.10 % w/w.   https://jmpas.com/abstract/1044

Although Low back pain puts an immerse economic strain on healthcare services, this disease is responsible for impacting people’s daily lives. Sleep quality has gained interest for people with musculoskeletal pain conditions as a contributing factor to the outcome. Sleep consistency has created consideration as a risk factor to the outcomes for people with MSK pain disorders. According to several studies, there is a bidirectional relationship between pain severity and sleep quality. The recent focus on the interaction of inflammatory processes in pain and sleep, on the one hand, leads to neuro-immunological pathways that may contribute to the close relationship between pain and sleep, on the other. To study association of poor sleep with low back pain among symptomatic and asymptomatic population. All asymptomatic and symptomatic individuals with low back pain in the group between 35-50 years of age filled the survey using Visual Analogue Scale (VAS) and Insomnia Severity Index Questio...

Enterococci are Gram-positive, ovoid cocci that can be found as diplococci or in short chains. These species are found in the typical microbiota of the intestine, oral cavity, vagina, and other areas. Despite being commensals with moderate virulence, these species have lately emerged as important nosocomial infections with increasing drug resistance particularly to vancomycin. This has resulted in their changing patterns of infection that are resistant to conventional antimicrobial therapy. The main objective of this study was to assess the frequency of the VanA genotype among Vancomycin Resistant Enterococci, as well as the isolation, identification, speciation, and antibiotic sensitivity pattern of Enterococci from various clinical specimens. In this six-month study, 500 different clinical specimens such as urine, blood, and pus were collected aseptically from patients suffering from urinary tract infection (UTI), septicemia, and pyogenic illnesses, and a total of 94 Enterococci stra...

Since early in month of Dec-2019, the infection of Coronavirus Disease 19 has been prevalent in Wuhan City of China and ultimately virus spread to other countries. Literature survey was carried out by using different scientific sources such as PubMed, Scopus, Google scholar etc. There is a scarcity of literature of COVID-19 happening at some stage in pregnant women and possibilities of transmission vertically are may be due to COVID-19. So, there is an alarm situation as foetus may be at risk of congenital COVID-19. Up until August 28, 2020, we investigated at the risk of COVID-19 vertical transmission to the foetus of infected women using a database of published articles and government sites. Middle East Respiratory Syndrome MERS and Severe acute Respiratory syndrome SARS were related to poor obstetrical conclusion, so there was no recognized case of ‘intrauterine transmission’ of either Middle East Respiratory Syndrome-coronavirus (MERS-CoV) or severe acute Respiratory syndrome-coron...

The nurses’ population comprises of almost majority of the health care staff in the hospitals and other clinical settings. This population was undermined in the past but in recent years, many studies have been focused on this group to increase efficacy along with analyzing and reducing adjoining risks. The illness most frequent for absenteeism and quality of work hampering is back pain. Hence, this study targets the interventions for low back pain in the nurses. The participants (n=120) will be selected from the hospital setting and divided into 3 random groups. Group A will perform work station exercises, group B will undergo ergonomic changes and advices and group C will be the control group. Each group will have 40 participants each and the participants will implement the interventions of the allotted protocol for 2 months. The initial and final changes will be noted as day 1 and day 60. The outcome measures used will be Visual Analog Scale for pain rating and WHO Quality of Life sc...

Indian population has potential threat of communicable and non-communicable diseases. The low preventive health measure is a cause of major loss to the economy. Integration of the cloud platform with remote wearable sensors not only helps the health stakeholders to capture the patient vitals but also perform predictive analysis during COVID-19. Raising timely alarms through Internet of Medical Things and Artificial Intelligence has wide application in preventive care through real time analytics. However, Health Merchandise Startups using artificial intelligence and machine learning for timely device delivery face delay in making themselves available and affordable for Remote patients of Tier II and III. This study takes a health service provider perspective and seeks to study problem situation systemically by using a casual loop model. Finally, analysis of the feedback loops is done to be able to come out with suitable strategies for COVID-19 patients of Remote locations.   https:/...

The elbow, which is the upper limb's intermediate joint, is prone to pathological occurrences and stiffness in particular. As a patient's ability to perform compensatory motions deteriorates, intolerance develops. Individuals frequently suffer from fractures and dislocations. Prior to treatment, a thorough examination is required. Physical therapy is crucial in the recovery of function. The purpose of this research is to examine the benefits of regular stretching vs. PIR in the muscle energy technique on postoperative elbow stiffness, discomfort, and range of motion. A Randomized Control Trial will be used to conduct the research. A total of 20 participants will be chosen from AVBRH and RNPC OPD, Sawangi (Meghe) , based on inclusion and exclusion criteria. Twenty subjects will be divided into two groups, with one group receiving Stretching (static stretching) and other receiving Muscle Energy Technique (Post isometric relaxation). The patient's outcome measurements will be ...

Epithelial Sodium Channel (ENaC) is a protein that plays a role in maintaining sodium levels in the body. ENaC protein is abundant in the intestines, lungs, and kidneys. ENaC protein levels were measured from specific locations where the kidneys would be a good source of sodium excretion associated with hypertension. ENaC protein is one of the biomarkers hypertension based on lifestyle because it is related to sodium intakes in the body. ENaC protein is a biomarker of hypertension because it plays a role in sodium ion transport in cells which is related to blood pressure levels. Most hypertension or high blood pressures are not diagnosed on time because they are asymptomatic and existing protocols are less effective. The method to detect ENaC protein has been developed and can be a solution to this problem. This review describes various methods to detect ENaC protein as a biomarker of hypertension.   https://jmpas.com/abstract/1037

One of the most common fractures seen in emergency rooms is distal radial fractures (DRF), which commonly occur when an upper extremity is broken. A FOOSH injury is one that occurs when the mechanism of injury involves a dorsal bending force being applied across the distal radial (fall onto an outstretched hand). The DRF has a bimodal distribution and is the most common upper limb fracture across all age groups, peaking in young men and postmenopausal women with an incidence ratio of 1:4. A randomised controlled experiment was conducted to evaluate and analyse the improvement in functional status and pain in patients who followed a home exercise programme without supervision and a physiotherapy plan under observation. A comprehensive analysis of Following some upper limb fractures, exercise helps patients function better and minimises disability. A randomised controlled trial comparing the effectiveness of physical therapy alone to physical therapy and occupational therapy in patients ...