Journal of Medical Pharmaceutical and Allied Sciences

  The purpose of this study was to investigate the effect of proprioceptive neuromuscular facilitation on the balance and gait required for functional activities in patients with Parkinson's disease. 16 patients were randomly assigned to an experimental group receiving Proprioceptive neuromuscular facilitation (PNF) and a control group receiving functional electrical stimulation. BBS, POMA, and TUG were used before and after intervention to evaluate balance and walking ability required for functional activities of patients. In the study results, all groups showed a significant increase in intra-group evaluation using BBS, POMA, and TUG, and in the analysis to investigate the difference in treatment effect between groups, there was a significant difference in POMA and TUG in the experimental group compared to the control group. In conclusion, the intervention method using PNF has a positive effect on the functional activity of Parkinson's patients. https://jmpas.com/abstract/115...

  Female genital tract infections are major public health problems, with considerable economic consequences. Drugs like metronidazole and clindamycin are unable to control the growth of vaginal infection completely, which requires alternate novel treatment strategies. Some herbal antimicrobial agents are reported to inhibit the growth of vaginal infection. Boerhaavia diffusa andAzadirachta indica are such herbs with antimicrobial, antioxidant and anti-inflammatory properties. In the present study, vaginal fluid samples from infected patients were collected and cultured using different media. Isolated pathogens were identified using 16S rRNA sequence. Four bacterial pathogens were isolated and identified. The pathogens identified were Aeromonas cavia, Lactobacillus, Staphylococcus aureus and Klebsiella pneumomiae. Anti-vaginalis activity of the two herbs were analysed in an isolated pathogen. Maximum zone of inhibition was observed against S. aureus and Aeromonas caviae. The present...

Traditional medicine is still used by the community to prevent and treat various diseases, including infectious diseases and exposure the free radicals. The part of the medicinal plant that is often used as traditional medicine is root bark of sungkai. This study explored endophytic fungi from root bark of sungkai and determined their antibacterial and antioxidant activities. Endophytic fungi were isolated from fresh root bark tissue in PDA (Potato Dextrose Agar) media and identified morphologically. The DPPH (2,2-diphenyl-1-picrylhydrazyl) and diffused-disc paper methods were used for antioxidant and antibacterial. The endophytic fungi extracts showing the best bioactivity were identified molecularly. A total of 6 isolates of endophytic fungi were found in this study (RNA1-RNA6). Antibacterial and antioxidant activity test showed the best activity for RNA4 isolates. Molecular identification results describe it as Penicillium janczewskii. This research can be used as a basic reference ...

  Gastric ulcers are a common gastrointestinal disease with a complex etiology. It manifests with various signs and symptoms, which, in severe cases, could be life-threatening, especially in developing countries. Medicinal plants have been known to exhibit therapeutic potential with minimal adverse effects and thus have been employed in treating various diseases. This study evaluated the effect of ethanolic Myrianthus arboreus leaf extract on indomethacin-induced gastric ulcers in adult male Wistar rats. Twenty-five rats were divided into five groups of five rats each: group A received distilled water; group B received distilled water for 14 days, and 30 mg/kg body weight of indomethacin after 24 hours of fasting. Group C received 20 mg/kg of omeprazole for 14 days and 30 mg/kg of indomethacin after 24 hours of fasting. Groups D and E received 50 mg/kg and 100 mg/kg of M. arboreus, respectively, for 14 days and 30 mg/kg of indomethacin each after 24 hours of fasting. The ulcer inde...

  High genetic variability of the hepatitis C virus (HCV) due to copying errors during the viral cycle leads to the development of mutations, and resistance-associated variants (RAVs), even with the advent of direct-acting antivirals (DAAs). Assessment of the presence of these mutations is essential for targeted treatment regimens and proper infection management, as treatment is related to genotypes and developing mutations. The study investigates the presence of resistance mutations in the nonstructural protein 5B (NS5B) region in treatment naïve patients. 100 positive plasma samples from patients presented for a follow-up service of chronic HCV infection (CHC) at the National Institute of Hygiene (NIH) of Rabat-Morocco. NS5B sequencing revealed the presence of C316N in one treatment naïve patient of subtype 1b. Additionally, six treatment-naïve patients with subtypes 2a and 2i exhibited the presence of the M289L mutation. https://jmpas.com/abstract/1148

  Button batteries are increasingly becoming a common foreign body ingested by children, thanks to their ubiquitous presence in the multitude of common household articles /devices. Unwitnessed button battery ingestions pose a diagnostic challenge, in that, the symptoms mimic that of a GI upset. The diagnosis may be missed/ delayed unless there is a high index of suspicion. A multidisciplinary approach involving primary care Pediatricians, Pediatric gastroenterologists and Pediatric surgeons is often needed to effectively manage these children. Timely intervention can avert serious complications. https://jmpas.com/abstract/866