Journal of Medical Pharmaceutical and Allied Sciences

 Owing to the poor water-solubility and/or first-pass metabolism leading to a low bioavailability of AMD, several approaches have been studied by scientists for a solution. Inclusion complex and solid dispersions have been effective in improving the solubility of AMD whereas nanomedicine offers an excellent platform for overcoming all the problems of bioavailability. Nanocarriers, liposomes and LNCs have been effectively used in experimental studies for the same. Epicardial application of AMD hydrogels have been clinically evaluated to improve the bioavailability of AMD in post operative atrial fibrillation whereas a bilayered transdermal patch applied on epicardium was also found to be equally effective in goat. For complete details visit: Ragni Kumari, Virendra Sharma, 2022. Strategies to improve amiodarone bioavailability in post operative atrial fibrillation. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4483 - 4488 doi: 10.55522/jmpas.V11I1.2540.

 This research concluded that Fluocinolone-acetonide is incorporated into nano-emulsion formulation by ultra-sonication technique for the improvement of solubility and absorption. Nanoemulsion is more desirable for the transdermal drug administration because it enhanced absorption rate through skin. Nano-emulsions have characteristics that make them more effective transport system than macro-emulsions as they do not show the problem of agglomeration and sedimentation which are generally associated with macro-emulsions. On the basis of ternary phase diagram and drug solubility test Tween-20, Oleic acid and Polyethylene Glycol 400 was selected and these are eminently used as an appropriate transporting system for introducing Fluocinolone-acetonide for transdermal drug delivery. Five formulations were formulated as per the composition of nano-emulsion. The developed nanoemulsion formulation coded as F1, F2, F3, F4 and F5. Several evaluation parameters such as droplet size distribution...

 In this paper, reported the synthesis of two Schiff base mixed ligand Cd (II) metal complexes namely [Cd(L)(diimine)] (1, 2) [where L = 2-(2-hydroxy-2-methyl-1-phenylpropylidene) hydrazine carbothioamide; diimine = 2,2’-bipyridine (1), 1,10-phenanthroline (2)]. The complexes were elucidated by the use of various techniques. The antibacterial properties of Schiff base and its metal complexes were investigated against a varied range of Gram-positive and Gramnegative bacterial strains. Also, the antifungal and antioxidant assays were studied. The complex-1 shown better biological activities for antibacterial and antifungal, whereas complex-2 shown good DPPH scavenging activity. For complete details visit: Vanitha Sanambatla, Sathish Kumar Nara, Balaji Hari, Varada Reddy Ammireddy, Saritha Nimmakayala, 2022. Antimicrobial and antioxidant studies of Schiff base, 2-(2-hydroxy-2-methyl1-phenylpropylidene) hydrazine carbothioamide and its mixed ligand cd (II) complexes. J. Med. P’ceu...

 The action of an effervescent formulation was accelerated. Effervescent tablets were made using the Dry, Wet, or Compression methods, with the Wet approach being the most common. Effervescent granules were made using a wet process, such as the Fusion method, or a dry way with the Fusion method being the most important. As a result, electrolyte effervescent tablets be used in the case of dehydration. This formulation is convenient to store, transport, and carry. Also, provide an accurate dose. Electrolyte Effervescent tablet prepared by using various super disintegrates like sodium bicarbonate, citric acid, Polyethyleneglycol-6000, PVP, Polyethyleneglycol-6000, PVP, Mannitol, Tartaric Acid, and F3 by Fusion method was found to be the best formulation as it exhibited satisfactory physical parameters, least solution time (1mins 46sec.), PH of solution (6.79), Hardness 2.5kg/cm3, thickness 6.8mm. For complete details visit: Arpan Kumar Tripathi, Yogesh Vaishnav, Isha sonker,...

 The antimicrobial activity of the EOs of M. pulegium, M. suaveolens and M. Spicata has been proven. This activity was displayed to be stronger compared to this generated by the hydrosols from the same species. The high concentrations in EOs of carvone and pulegone can be used as an explanation for the traditional uses of these Mentha species for the treatment of microbial diseases. The obtained results about the antibacterial power of HYDs are promising; these HYDs have demonstrated their potency as antibacterial agents since they have exerted an inhibitory effect on some treated bacteria. This potential can be attributed to their richness in the phenolic and alcohol components. On the other hand, the antimicrobial properties of HYDs depended mostly on the individual susceptibility of bacteria. Consequently, the use of HYDs to fight pathogenic bacteria may be possible especially they are tolerable (low organoleptic flavor), highly soluble and not volatile (high stability). These p...

 We got to the conclusion that there are no precise rules for maintaining COVID-19 linked waste after reading all of the legislation and recommendations or templates provided by WHO, the United States, Europe, Japan, and India. If this trend continues, it may have an impact on not just trash-handling employees, but also the entire ecosystem, since animals and birds may come into touch with COVID-19 associated wastes tossed in an open area, potentially spreading COVID-19. Before COVID-19 waste management becomes a major issue, proper rules must be drafted and implemented by the individual governments. Individuals should be obliged to adhere to the rules. That is how strict the guidelines should be. The guidelines should not just exist on paper; they should be followed appropriately by each individual only then the nation can be saved. For complete details visit: Abimanyu Sugumaran, Ramya Ravichandran, Kamaraj Raju, 2022. Role of regulatory agencies on covid-19 waste manage...

 Angiogenesis has a notable role in tumour progression. So, effective inhibition of tumour angiogenesis might-arrest tumour growth and by dialysis. Hence, it might be essential for cancer treatment. Having followed research articles, we got information. We hope, this ongoing research work becomes fruitful in the future for cancer treatment. For complete details visit: Swarupananda Mukherjee, Moumita Kundu, Monalisa Chatterjee, 2022. Angiogenesis inhibitors in cancer treatment: . J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4451 - 4454 doi: 10.55522/jmpas.V11I1.2450.

 Our study found that propofol can be an alternative to sevoflurane as ideal induction agent which can provide comparable and suitable condition for placement of LMA in children particularly in resource limited settings where costly sevoflurane vaporizer is not available. For complete details visit: Amit Pradhan, Ayesha Pattnaik, Sarat C Jayasingh, Sidharth S Routray, Abhishek Barpanda, 2022. Propofol-an alternative to sevoflurane for laryngeal mask airway insertion in children. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4444 - 4447. doi: 10.55522/jmpas.V11I1.2655.

 The clinical diagnosis of voiding dysfunction is on the basis of exclusion of organic causes of urinary symptoms like frequency, urgency, wetting day and night time, dysuria and associated UTI’s and constipation. Though it is often suspected in children with no underlying structural abnormalities until the advent of uroflow EMG the means of establishing a diagnosis was purely subjective in nature. uroflow EMG offers a tool which is simple and relatively easy to perform on an outpatient basis with stratification into types described earlier. The authors concluded that uroflow EMG to be a useful tool in the management of children with voiding dysfunction as it helped in identification of the exact nature of the problem on an objective basis. For complete details visit: Ramdoss PothiNathan, Ahila Singaravel Chidambaranathan, 2022 Clinical profile of voiding dysfunction with uroflow EMG correlation in children. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4438 - 4443 d...

 Preimplantation genetic diagnosis is an assisted reproductive technology for embryo screening by detecting defects caused by gene and/or chromosomal abnormalities. The ultimate goal of this screening is to prevent implantation of the fetus or limit the risk of transferring embryos carrying genetic disorders. Polar body I and II biopsy are one way to detect genetic disorders that occur in oocytes more safely, the risk of harming the oocyte is less and causing no damage to oocyte development and viability compared to blastomere biopsy and blastocyst biopsy techniques. Polar bodies have the same genetic material as oocytes and the results obtained from the diagnosis of polar bodies are a reflection of the condition of the oocyte. Several techniques can be used for biopsy of polar bodies I and II such as Mechanical Partial Zone Dissection (PZD), chemical zone drilling and laser-assisted dissection. The methods that can be used for the diagnosis of polar bodies are PCR, FISH, CGH array...

 The replacement of synthetic with natural antioxidants, because of implications for human health, may be advantageous. The present study reported the antioxidant activity, quantitative analysis of total phenolic and flavonoid contents of an endemic Moroccan species: Artemisia ifranensis. In order to realize the health benefits from potential plant sources, it is important to measure the antioxidant activity using radicals and oxidation systems. In vitro, The ethyl acetate extract exhibited highest toalphenolic and flavonoids content (35,81 mg GAE/g Extract and 31,85 mg QE/g Extract respectively) and possess highest antioxidant activity (IC50 value 0,656 mg/ml) compared to crude and butanolic extracts. Heterogeneity in the correlation analysis has been observed, it is widely accepted that this is not necessarily the high content of phenolic compounds exhibits a powerful antioxidant activity, but also the chemical structure of the antioxidant compounds. For complete details vis...

 The main goal of any anticancer therapy is a favorable outcome for the patient. The reduction or interruption of Multikinase inhibitor therapy can adversely affect patient outcomes through the removal of a potentially life-sparing therapy. Therefore, the symptoms of cutaneous adverse drug reactions should be recognized as early as possible to initiate therapeutic management before withholding therapy becomes necessary. For complete details visit: Anjali Lalani, Helly Sheth, Harsh Chudasama, Cyril Sajan, 2022. Renal cell carcinoma, multitargeted tyrosine kinase inhibitors, Fixed drug eruption. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4417 - 4418. doi: 10.55522/jmpas.V11I1.2489.

 In conclusion, PRP may support the proliferation and differentiation of SSCs in vitro and could be developed into an alternative for FBS in the human SSC culture system. For complete details visit: Silvia W Lestari, Debby Aditya, Firda Asma’ul Husna, Gita Pratama, Dwi Anita Suryandari, Kanadi Sumapradja, Ria Margiana, Puji Sari1, Ria Kodariah, 2022. Human spermatogonia stem cells (SSCS) in a culture system with platelet rich plasma and correlations with spermatogenesis level. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4409 - 4416 doi: 10.55522/jmpas.V11I1.2401.

The pGALS examination scale reveals that the musculoskeletal abnormalities among the young individual of the age 5yrs to 12 yrs. wherein shows that there is minimal individual having abnormalities according to the pGALS examination scale. For complete details visit: Devyani A. P, Prasad P. D, Pratik P, Sakshi P. A, 2022. Orthopedic screening using pGALS assessment tools in children’s between 5 and 12 years. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4405 - 4408 doi: 10.55522/jmpas.V11I1.1348.

 By the above systemic review, we concluded that the most comorbid condition was hypertension followed by diabetes mellitus, and the symptomatic assessment was found to be dry cold, myalgia, and sore throat and which has been a risk for the treatment of COVID-19, and hence the mortality rate also seems to be higher in these two cases. For complete details visit: Dharani Shrinivasan VP, Kameswaran Ramalingam, Senthil Madasamy, Sambathkumar R, 2022. A systematic review on sars-COVID-2: Risk and its comorbidities. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4396 - 4399. doi: 10.55522/jmpas.V11I1.2308.

 Eco-Pharmacology is a broad area where abundant information is not given. Nowadays our planet earth is being impure with toxic waste, pharmaceuticals, chemicals, garbage waste etc causing an impact to the humans, terrestrial and aquatic ecosystem. People are not educated and not being aware on the impact of unused and expired medicines in our environment and health effects. Still there are not much effective measures on how to dispose pharmaceuticals present at our households. Therefore, it is important as pharmacist to advise and take measures in educating the patients about stocking medications, keeping away expired medications at home and not properly disposing can cause aquatic species to die. Since the waters are polluted, it is not safe for human beings to drink water that is not purified. It is necessary to start taking proper strict measures in ways to dispose medications and toxic substances and make our environment cleaner and safer place to live. For complete detai...

 With the limitations of this study, it can be concluded that the prepared aloe vera gel containing Carbopol 934 has positive and favourable effects on the wound healing process following gingival depigmentation. Therefore, a gel containing aloe vera can be a natural alternative to chemically formulated gels. As it is highly effective and inexpensive and has favourable results towards healing, its usage should be encouraged. For complete details visit: Naina Pattnaik, Sangram Patro, Abhitosh Debata, Subash Chandra Nayak, Monalisa Panda, Monalisa Das, Anasuya Sahoo, 2022. Clinical evaluation of effect of aloevera gel formulation for healing following gingival depigmentation. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4385 - 4390 doi: 10.55522/jmpas.V11I1.2244.

 Upper limb Plyometric in physical training protocol has significant effect on the performance of the badminton player when given for at least 6 weeks. Significant improvement was seen in agility balance and speed of the player. For complete details visit: Simran N, Pratik P, Neha C, Sakshi P A, 2022. Efficacy of Upper Limb Plyometric Training in a Badminton Player: A Case Report. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4214 - 4217 doi: 10.55522/jmpas.V11I1.1347.

 A simple, accurate, specific, precise, robust, rugged and rapid reversed phase high performance liquid chromatographic (HPLC) method for the analysis of esomeprazole has been developed and validated. Method validation was conducted inline to ICH requirements, and all the parameters were acceptable. The method validation proved the stability indicating characteristics of the developed method. Thus, this method can be used for analysis and to check the stability testing of esomeprazole formulation. The developed method could be employed to distinguish batches with suboptimal product quality for delivery through nasogastric tubes. The aim of this publication was to develop a stability indicating method and provides additional information on utility of esomeprazole for individuals with swallowing difficulties. Unlike previous studies that have measured proton pump inhibitor delivery by counting drug particles, our study measured proton pump inhibitor delivery using HPLC techniques [39...

 Crystalloid co-load reduced the incidence of intraoperative hypotension and the need for vasopressors in parturients undergoing caesarean section under spinal anaesthesia compared to crystalloid preload. For complete details visit: Aradhana Devi, Mekha Elizabeth, Olvyna D'Souza, 2022. Crystalloid preload versus crystalloid co-load for hypotension in parturients undergoing caesarean section under spinal anaesthesia. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4370 - 4374. doi: 10.55522/jmpas.V11I1.2213.

 In present study, in vivo antidiabetic activity of some benzamide derivatives have been performed in STZ-nicotinamideinduced diabetic model in rats. The antidiabetic potential has been determined by estimating different biochemical parameters such as body weight (g), serum glucose level (mg/dl), serum total cholesterol (TC) (mg/dl), serum HDL-cholesterol levels (HDL-c) (mg/dl), serum LDL-cholesterol level (LDL-c) (mg/dl), serum VLDL-cholesterol level (VLDL-c) (mg/dl), serum triglyceride (TG) level (mg/dl),serum glutamic-oxaloacetic transaminase (SGOT, AST) (U/L), and serum glutamic pyruvic transaminase (SGPT, ALT) (U/L). As antioxidants helps to prevent the generation of free radicals which ultimately prevent biological damage of the cells and tissues. We have determined different antioxidant parameters such as superoxide dismutases (SOD) (U/mL), catalase (CAT) (kU), malondialdehyde (MDA) (μM), and reduced glutathione (GSH) (mg/dl). Amongst all the tested molecules, compound 5h de...

 Results obtained by validation studies suggested that the developed stability indicating assay method is simple, precise, accurate, specific, robust, rugged and possess stability indicating characteristics. Thus, this method can be used for routine analysis and to check the stability testing of Apixaban formulation. The methods developed in this study could be used to distinguish batches with suboptimal product quality for delivery using NG tubes and to confirm the substitutability of generic drug products for this alternative route of administration The purpose of this publication was to develop a stability indicating method and provide additional information on the clinical utility of Apixaban, particularly for individuals with swallowing difficulties. A suspension of Apixaban in 5% dextrose and water were identified as suitable for administration through enteral feeding tubes. The recovery of Apixaban after passing through the selected enteric feeding tubes was found to be...

 The present Immunohistochemistry study demonstrated the presence and distribution of DCs in the endometrium of hysterectomy specimens, both in normal and malignant specimens. An increase in number of DCs was observed in normal endometrium, while a statistically significant a smaller number of DCs was observed in uterus harboring malignancy. For complete details visit: Kalpana Ramachandran, 2021. An immunohistochemical study on the distribution of CD1a dendritic cell density in normal and pathological lesions of the human uterus. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4353 - 4357. doi: 10.55522/jmpas.V11I1.2154.

 Centrifugal spinning process has gained momentum in the last decade with aggressive research been undertaken at a rapid pace. It offers an economical, scalable, highly productive, and “greener” technique for fabricating nanofibers. The technique has attracted the interest of academia and industries as evidence from the increased number of patents filed and research work published worldwide. This versatile method overcomes several limitations imposed by the existing nanofiber production techniques. By altering the inherent features of the spinning fluid and the operational conditions, the morphological characteristics of centrifugally spun nanofibers can be tailored. Centrifugal spinning due to its cynosural features and divergent applications may prove to be a game-changer in the commercialization of nanofibers. With further progress in the detailed investigations on the material properties, device setup, and improvements, centrifugal spinning technology will develop and prog...

 Within the limitations of the study the authors concluded that  1. The flexural strength of 2.5% Zirconia,2.5% Titanium oxide and 2.5% Aluminum oxide nanoparticles reinforced heat polymerized PMMA provisional resin after 24 hours fabrication in distilled water and 2 weeks of fabrication in artificial saliva were 195.96,189.34, 189.65, and 196.29, 193.49, and 187.89 respectively. The 2.5% Zirconia nanoparticles reinforced heat polymerized PMMA provisional resin showed statistically significant flexural strength compared to 2.5% Titanium oxide and 2.5% Aluminum oxide nanoparticles reinforced provisional PMMA resin.  2. The surface hardness of 2.5% Zirconia,2.5% Titanium oxide and 2.5% Aluminum oxide nanoparticles reinforced of heat polymerized PMMA provisional resin after 24 hours of fabrication in distilled water were 36.6, 34, 34.6 VHN and 2 weeks of fabrication in artificial saliva were 36.3, 34.2, 34.6 VHN thus, , 2.5% Zirconia nanoparticles heat polymerized PMMA provi...

 Brazil with an emerging market and population over 200 million is the major target and outlook for various Bio/Pharmaceutical companies around the globe. Even though it is one of the largest pharmaceutical markets, it has its challenges. For example, exporting of drugs to Brazil is a difficult task as it takes over couple of years for registration and further inhibition is that all communication should be done in their native language which is Portuguese. ANVISA has brought many new resolutions which has increased the quality of registration of medicines in Brazil. As ANVISA has officially became ICH member, it is striving to meet ICH guidelines. ANVISA has introduced generic drug act in 1999 and comparability pathway for biosimilars in 2010; which has reduced the cost of medicines in Brazil. There are various challenges for biologics in Brazil which may include nomenclature, interchangeability, extrapolation indications. In spite of having challenges, hindrance and on-uniformity ...

 In this case above rehabilitation protocol had significantly reduce the pain and tenderness, improved ROM , muscle strength and endurance which helped patient to restore his functional independence at home and work. For complete details visit: Anjali Vikas N, Swapna J, Om C W, 2022. Effect of Novel based Postoperative physiotherapy rehabilitation on functional outcome in Malunited supracondylar fracture of femur and proximal tibia fracture following implant removal. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages – 4328 - 4331. doi: 10.55522/jmpas.V11I1.1342.

 Galectin-3 is a very delicate and specific marker in diagnosing papillary carcinoma thyroid and its variants. Though diagnosis of conventional papillary carcinoma is not that difficult, dilemmas arise more often in follicular variant which can be easily sort out with the additional help of galectin -3 apart from routine histopathological sections. Also galectin 3 helped in differentiating benign and malignant cases. Limitations of the study are only papillary carcinoma thyroid and its few variants were included in this study whereas other thyroid carcinomas are not included. Also these findings are based on limited number of cases which has to be corroborated with larger cohort. For complete details visit: Thiripurasundari Ramasamy, Sasidhar Repana, Jacqueline Lourdes, ShanmugaPriya Velayudhan, Thiripurasundari Ramasamy, 2022. Assessment of Galectin-3 in Thyroid Lesions Expression through Immuno-histochemical approach. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4280 -...

 The selected plants were found to have profound effect, on improving the dopaminergic transmission which was evidenced by reduction of catalepsy, improvement in muscle strength, enhancement of spatial learning and memory processes. These evidences suggested their neuroprotective potential in treating 6-OHDA induced parkinsonism in rats. Further clinical studies are essential for confirming its action on ameliorating the symptoms of parkinson’s disease in patients and thus improving their quality of life. For complete details visit: Vanna Manjusha, D Kulkarni Suresh, V Velappan Venkatachalam, 2022. Antiparkinsonian activity of moringa concanensis and sesbania grandiflora in 6-hydroxy dopamine induced parkinsonism in rats. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4324 - 4327. doi: 10.55522/jmpas.V11I1.2136.

 The floating pellets of febuxostat are prepared by extrusion and spheronization method using low density polymer gelucire 43/01 which can float pellets more than 12 hrs. and EC 20 cps retard the release rate up to 24 hrs. Concentration ratio of gelucire 43/01 and EC 20 cps with drug had significant effect on floating lag time while Drug: EC and combined effect of both independent variables had significant effect on % in vitro drug release It has been concluded from the present study is that use of gelucire 43/01 and ethyl cellulose 20 cps in optimized concentration gives floating ability to the pellets and provide gastric retention up to 24 hrs. for sustain release effect. After considering effect of independent variables on dependent variables and other evaluation parameters excellent batch of febuxostat pellets was selected. Batch B11 gives floating lag time (110.2±0.02 sec.) and maximum drug release at 24th hrs. (98.8±0.02) with all required physical properties in limit (f...

 The above study concludes that a definitive surgical approach and early physiotherapy rehabilitation lead to enhancement in the functional goals of the patient which stands a major understanding towards a successful recovery. For complete details visit: Ruchita R, Anushree P, Heena P, Neha C, Sakshi P. A, Pratik P, 2022. Impact of Physical Therapy on a Patient with Complex Comminuted Fracture of Elbow. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages – 4302 - 4305. doi: 10.55522/jmpas.V11I1.1341.

 The literature highlights various limitations and problems that have been encountered due to poor solubility of drug in water. Etodolac is having wide spectrum of activity as an antiinflammatory drug but has limited water solubility. The research study concludes that, the investigational solubility enhancement techniques can serve as a tool to modify the solubility of Etodolac making it more significant toward the therapy. The adaptability and applicability of Liquisolid method will boost the physicochemical interaction of drug with polymers allowing it to overcome barriers associated with the solubility. The aim and objectives of the research work are concluded by justifying the need and importance of the work entitled “Design and development of Liquisolid Fast Dissolving Tablet formulation of Etodolac”. For complete details visit: Bhamare Vaibhav G, Kamble Ravindra K, 2022. Design and development of fast dissolving liquisolid formulation. J. Med. P’ceutical Allied Sci. V 11...

 Anti-arthritic activity, Anti-oxidant activity, toxicity studies by CAM Assay has proved that stigmasterol and β-sitosterol shows a greater response of anti-inflammatory disorder correlates to arthritic activity, the oxidative response was determined by active response of stigmasterol and β-sitosterol in comparison to standard solutions. The toxicity of the phytosterols was examined for chondrogenesis of cartilage cells and infiltration of inflammatory mediators into CAM membrane, Stigmasterol and β-sitosterol may inhibit the role of inflammation that leads to osteoarthritis. Researches have established the fact that inflammation may be the common factor in many diseases that also have been underlying the cause of degenerative disease such as osteoarthritis. From this study we can conclude that stigmasterol and β-sitosterol prevent inflammatory effects by restraining IL and TNF α pathway construction that might have a response to lessen the symptoms associated with osteoarthritis....

 An Inter-trochanteric fractures of femur are one of the commonest fractures encountered in orthopedic practice. It is mostly seen in the older age groups. An increased incidence of these fractures is noted these days owing to the increased life expectancy. In a male patient that was with right sided Boyd and Griffin type 2 , was diagnosed by orthopedic surgeon , after a fall , on which on which open reduction and fixation with proximal femoral nailing SOS dynamic hip screw was done Although this clinical study shows that the classical surgical approach and the accelerated organized recovery of physiotherapy contributed to the enhancement of functional objectives i.e. decreased pain and tenderness, enhanced ROM, muscle speed and agility, which helped the patient regain physical function. For complete details visit: Sneha A, Om C. W, Swapna J, 2022. Novel physiotherapeutic approach towards a case of Boyd and Griffin Type 2 Intertrochanteric fracture. J. Med. P’ceutical Allied S...

 Physiotherapy play a crucial role in rehabilitation of patient with post-operative stiffness in crush injury patient in improving range of motion, strength and reducing functional disability of patient. For complete details visit: Purva G, Mithushi D, Neha C, Sakshi P. A, Pratik P, 2022. Advanced physiotherapy rehabilitation approach for postcrush injury stiffness patient on palliative physiotherapy. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages – 4263 - 4266. doi: 10.55522/jmpas.V11I1.1335.

 Let us move into a new phase of sustainable development goals and universal health coverage. It is worth noticing that onethird of the world's population still lacks access to life-saving medicines. Sophisticated advanced research should be focused to ensure an efficient and secure seamless supply chain which will encourage a position for pharmacologist in the global context of problems such as substandard and falsified drugs and shortage of human capital in the health sector. In this literature, information and encouraging findings provided a global overview of the pharmacist's impressive position in the pharmaceutical supply chain. Given the complexity and length of the pharmaceutical supply chain, which necessitates the expertise of various disciplines with varying ability levels, it is unsurprising that the position of the pharmacist varies across the world; even if the model can differ and provide highquality services. Pharmacists and other people involved in the supply, ...

 This research focused on estimating FA and CA in distinct Ananas comosus varieties based on their geographical distribution. This research will aid in identifying the content of FA and CA in medicinal plants, which could be valuable in the future in pharmaceutical and food preparation. This proven method can also be used to assess quality, ensuring that the content of FA and CA in various pineapples is consistent. For complete details visit: Mrinmoy Nag, Souvik Biswas, Arijit Das, Dipan Roy, Tathagata Roy, Debajit Dewan, Rakesh Kumar Paul, Mithun Bhowmick, 2022. Developed and validated method for the simultaneous estimation of ferulic acid and chlorogenic acid in four indian ananas comosus merrill cultivars through HPTLC. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4250 - 4255 doi: 10.55522/jmpas.V11I1.1639.

 The present investigation support the use of Hibiscus rosa sinensis in folk medicine against urolithiasis . It is concluded that administration of ethanolic extract of hibiscus flower prevent the growth of urinary stones. The mechanism collectively supported by the activity of analgesic, hepatoprotective, antioxidant, hair growth activity. For complete details visit: Manoj Kumar Sahu, Gurdeep Singh, 2022. Hibiscus rosa sinensis, Structural identification through GC mass spectrophotometer and determine anti lithiotic activity of hibiscus rosa sinensis by using ethylene glycol induced method. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4244 - 4249 doi: 10.55522/jmpas.V11I1.1575.

 The current study is carried out to find out association of postural with Quality of life in females undergone Modified Radical Mastectomy various studies conducted have shown postural deviation in females with breast cancer also that their Quality of life is altered resulting in various difficulties. Current study will be carried to find out whether there is any correlation between posture and Quality of life because changes in posture and spine may affect the working of women whether it may be at work or in household activities because of muscle tightness or other musculoskeletal changes causing restriction at joint decreasing ROM and pain preventing the female to carry out various activities efficiently which may ultimately affect Quality of life. Thus current study aims to find out association between posture and Quality of life. For complete details visit: Aachal B, Om C W, Neha C, Shalaka D, 2021. Evaluation of Posture and Quality Of Life in Females undergone Modified R...

 Collectively, the present study investigates the green route of synthesis of nanosized copper particles using S. swietenioides roo extract as green reducing agent for the capping of NPs. The NPs were characterized and confirmed that the NPs were observed to be aggregates with spherical shape and undefined shape with an average size of 32±4 nm with metal content was 82.5 %. Further the Cu NPs were applied for its photocatalytic degradation of Sudan red dye, Azure A dye and Lead metal in aqueous solution. Based on our findings, it can be confirmed that the NPs were having high degradation efficiency with less contact time was observed on the studied dyes and metal studied. Thus, the synthesized catalyst proved as promising material in photocatalytic domain for environmental depollution of aquatic dye/metal pollutants. For complete details visit: Tulasi S Lakshmi, Swamy AVVS, Peddi Pavani, Rani N Usha, 2022. Green adeptness in the synthesis and stabilization of copper nanoparticles u...

 A lipid nanoparticulate drug conveyance framework (SLNs) of Daunorubicin was proposed for cerebrum focusing through intranasal conveyance in the current exploration work. SLNs were ready by the homogenization and ultra-sonication process and assessed for molecule size, molecule size dispersion (PDI), zeta potential, capture productivity, in vitro delivery, and security studies. It was seen that all estimations were in a satisfactory reach. To plan strong lipid nanoparticles of reproducible sizes in the scope of 137.3 to 306.8 nm by tending with the impacts of handling boundaries, rapid homogenization followed by ultrasonication procedure was utilized. The 33factorial plan application ended up being a helpful strategy for enhancing DNR-stacked SLNs. Utilizing a factorial plan, the necessary definition creation can be chosen to acquire DNR-stacked SLNs more modest than 200 nm, contingent upon the use of the cerebrum focusing on framework through intranasal conveyance. The utilizatio...

 Even though there are many scientific researches on this species, this study is highly unique as it is the first study to be done with the Anethum sowa L. grown in South Karnataka, as based on the geographical region the oil content as well as the phytochemicals present in the plant may vary. Anticancer potential of the plant grown in South Karnataka both the seed oil and seed extract has not been studied with respect to Colon Cancer cell line HCT116 as the majority of the study done was with Brine Shrimp lethal toxicity studies. The study also highlights on the pharmacological potential of Anethum sowa L seed oil, methanolic extract of this plant, which is an unique element of this study and the various studies done were antioxidant , antimicrobial, anticancer ,anticollagenase and Insilco docking studies of Anethum sowa L. Seed essential oil was more effective in its antimicrobial, anticancer and anticollagenase properties when compared to the methanolic seed extract , but the an...

 The antibacterial and antioxidant capabilities of M. calabura bark may be extrapolated from the given results. These qualities are due to a range of phytochemicals found in this plant extract, including alkaloids, phenols, flavonoids, and diterpines. The ethyl acetate extract has a good antibacterial and antifungal activity against the microorganisms tested. In methanol extracts, the plant showed excellent antioxidant activity. The significant antioxidant activity of the extract shows that ethyl acetate bark extracts might be employed as a natural antioxidant source. More study is needed to understand the mechanisms behind these plant extract activities, which, based on our findings, might open up a new window in the hunt for novel bioactive drug lead components in these plant extracts. For complete details visit: Rakesh N Chaudhari, Amit Kumar Jain, Vivekanand K Chatap, 2022. Flavonoid, Therapeutic efficacy, Traditional medicine, Neuroprotective effect, Alternative therapy. ...

 In experimental animals given the medication orally at a high dose of 400 mg/kg, no death was observed. The drug's toxicity investigation in rats revealed the drug's benign nature on the hepatic, renal, and hematological systems, even at a high dose level of daily administration for 28 days. It is obvious from the foregoing findings that Sivanar Amirtham had no harmful effect on rats. For complete details visit: Moushumi Baidya, Anbu Jayaraman, Himangshu Sekhar Maji, Ramya Krishna P S, Dibya Das, 2022. Evaluation of acute and sub-acute toxicity of sivanar amirtham in albino mice and wistar albino rats. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4196 - 4204. doi: 10.55522/jmpas.V11I1.2217.

 Wound infiltration is a low-cost, safe, and effective means of controlling post-operative pain. It produces instant analgesia that lasts for a few hours without causing any significant side effects. Preincisional wound infiltration had better post-operative analgesia, as judged by the VAS, than the post-incisional category wound infiltration. Effective pain control promotes early ambulation, which lowers the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE); improves the patient's ability to take deep breaths. For complete details visit: Santosh Kumar Tiwari, Abhay chandra Srivastav, Chandra shekhar Azad, 2022. Pre-incisional versus post-incisional wound infiltration of bupivacaine for post-operative analgesia in abdominal procedures: a comparative analysis. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4192 - 4195. doi: 10.55522/jmpas.V11I1.1877.

 This review proposes suggestions for inconsistent approach in future studies on gait evaluation in healthy workers and importance of occupational impact on gait alterations. It is not possible to estimate accurately an occupational gait change from existing records, but enough facts is existing to recognize job-related hazards which will prove helpful for a better understanding and to manage gait adaptation. Further, the students, researchers, and investigators of different disciplines can integrate the understanding of gait into their field and learn more. Thus, we should sensitize the workers across multiple worksites about the effect of alterations of gait in the workplace and the risk associated with various occupations. In light of this review, future research should identify specific risk factors for work-related adaptations of gait as well as the necessity of providing quantitative exposure measures to enforce these adaptations. For complete details visit: N Esakkiamma...

 According to preclinical research, various specific flavonoi ds have more potent therapeutic value for thetreatment of epileptic di sorders. In addition, quercetin may have moderate therapeutic efficacy in an amygdala kindling model, it is also used to treat refractory epilepsy. While AEDs are beneficial for controlling seizures in epilepsy, 30 to 40% of individual patients with epilepsy do not respond effectively with conventional AED treatment after resistance to the drug. Furthermore, modern AEDs have limited therapeutic potential because of several complications, including dose-related neurotoxicity and altered circulatory processes. Certain flavonoids possess significant synergistic effects and can be taken with particular AEDs to reduce the possibility of drug resistance [47] . As a result, alternative treatments for seizures that are both effective and safe are extremely desirable. Recent research has found that flavonoids, specifically Temporal lobe epilepsy, can help with...

 In comparison to patients receiving intra-thecal buprenorphine, patients receiving buprenorphine in TAP block for inguinal hernia procedures reported longer duration of analgesia, lower pain scores, reduced analgesic intake during the first 24 hours, and fewer side effects. However, the analgesic intensity of intrathecal buprenorphine was superior to buprenorphine in TAP block until 4 hours. Buprenorphine is advised as an adjuvant in the era of USG-guided peripheral nerve blocks because it can provide prolonged duration of analgesia without centrally mediated side effects. Limitations of the research: Instead of using ultrasound to administer TAP block, well-trained senior anesthetists used landmark guidance. The VAS values were not calculated based on movement. For complete details visit: Santosh Kumar Tiwari, Abhaychandra Srivastav, Chandrashekhar Azad, 2022. Buprenorphine, Transversus Abdominis Plane block, inguinal hernia. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages ...

 The ethanolic and aqueous extracts were found to possess significant thrombolytic and anti-inflammatory activities. Hence it can be concluded that the thrombolytic and anti-inflammatory properties of the total ethanolic and aqueous extracts is due to presence of the phytoconstituents present in the root extracts. Thus, the results of the present study support the traditional use of the ethanolic and aqueous extracts of Capparis sepiaria root in the treatment of thrombolytic and inflammatory disorders. For complete details visit: Moushumi Baidya, Himangshu Sekhar Maji, Shvetank Bhatt, Dibya Das, 2022. In-vitro Evaluation of the Thrombolytic and Anti-inflammatory Activity of Capparis sepiaria Root Extracts. J. Med. P’ceutical Allied Sci. V 11-I 1, Pages - 4166- 4171 doi: 10.22270/jmpas.V11I1.1879. https://jmpas.com/abstract/864

 According to our results, thyroid abnormalities are more prevalent among women with uterine leiomyoma. Uterine leiomyoma is more frequently seen in patients of age group 40-49 years. History of prior abortion was found to be having 2 times for developing fibroid in patients with thyroid abnormalities while other risk factors such as elevated BMI, history of previous abortion and tubal sterilization, parity of age at menarche ≤ 13 and Parity ≤ 1 are not statistically significant. Patients with thyroid abnormalities are more likely to develop intramural fibroid. We found distribution of symptoms to be statistically non-significant among study groups, except for the abdominal swelling and pelvic pain. Therefore, the study demonstrates that there was no statistically significant difference between women with uterine leiomyoma who had thyroid problems and those who did not. For complete details visit:Keerthana N, C I Sajeeth, Mable John, 2022. Prevalence, risk factors and clinical prof...

 A BSE is regarded as a low-cost, fast, non-invasive, and non-hazardous technique. This could be a good way to detect breast carcinoma early in resource-poor nations where access to better screening methods is limited. BSE can be used as a tool to help females take better care of themselves. It has been demonstrated to raise awareness of breast abnormalities and breast carcinoma risk factors. Raising awareness may also encourage females to engage in healthy habits and participate in health-promoting activities. However, proper and comprehensive BSE procedure must be ensured, as well as fast and adequate medical assistance when required. There is a need to develop educational initiatives to improve female’s understanding and practice of breast self-examination. For complete details visit: Mehta Vaibhav, Patel Dipesh, 2022. A cross-sectional research of breast self-examination awareness and practice in rural women in central India. J. Med. P’ceutical Allied. Sci. V 11 - I 1, Pag...

 From these research findings, it can be concluded that the proposed method is simple, sensitive, specific and reliable with good accuracy and precision. Both analytes peak was well resolved. The major advantage of this technique is that it is developed for synthetic mixture and helpful for researcher to developed for its combined dosage form. Has, potential benefit for the quantification of both drug in commercially available dosage form by the pharmaceutical industry and analytical laboratories in Future. For complete details visit: Koli Priyal, Dudhrejiya Ashvin, Patel Ashok, Chavda Jayant, 2021. Analytical method for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan by validated RP-HPLC method. J. Med. P’ceutical Allied Sci. V 11 - I 1, Pages - 4154-5458. doi: 10.55522/jmpas.V11I1.1723. https://jmpas.com/abstract/860

 Our study concluded that the self-report scale (SRS) could measure the activity participation levels to the prescribed home-based exercises among stroke survivors. It is considered a safe and viable option for the home-based patient's optimal recovery program. This scale will be beneficial if used under the direct supervision of the caregiver. It is recommended that before Discharge from the hospital, the patient and their caretaker must be counseled and guide thoroughly regarding the importance of home-based exercises, their low-cost services, and if undone, can lead to serious long-term complications. Patients should therefore advise to take their homebased therapy carefully and consequently generate sufficient time for it. This can be done by providing adequate health education on how participation to home exercise could lead to the most optimal functional recovery. The possibility of inaccurate reminders, patient unavailability during follow-up are its limitations. Still, this...

 It symbolizes the meaning of Diabetes is a miscellaneous (various) collection of illnesses. This is represented by the fact that blood contains glucose. The primary goal of the American Diabetes Association [46] is "to prevent and secure diabetes and to develop lives that are astonishingly unaffected by diabetes." The primary assistance for individual lives all over the world, to try to classify as well as stop the inconveniences for diabetes at the start of the prescient anal-sister can be used to improve their arrangement systems. The proposed system also performs the investigation for highlight datasets as well as the selection of ideal highlights based on reputable relationships. relational relationships the two algorithms with the highest accuracy values are Random Forest and Decision Tree, which have 99.11 percent and 99.62 percent, respectively. Individual investigation is the best technique for collecting diabetic information. The Nave Bayes' and Support vector m...

 The present study demonstrated feasibility of BS-SD loaded lipidbased pellet formulation for enhancement in bioavailability. The obtained BS solid dispersion (batch F - 9) showed nearly 5-fold rise in solubility and dissolution behavior compared to BS. The BS solid dispersion further formulated into sustain release lipid-based pellets using extrusion spheronization technology. The optimization study indicated that sustain release pellets of BS (batch figure - 16) prepared with gelucire 43/01 (20%) and ethyl cellulose (5 %) was optimized showed maximum 95.69% drug release in 6 h. Increased Cmax, longer Tmax, and MRT with reduced elimination rate were found in a pharmacokinetic profile analysis in male Wistar rats, indicated sustained drug release behavior. The results of pharmacokinetic studies indicated improvement in relative bioavailability by 2.52-fold of optimized BS pellet formulation compared to BS marketed preparation. The designed system of BS lipid-based pellets with impr...

 HCWs' attitudes toward the Covid-19 vaccination vary depending on their age, education, occupation, and income. Vaccine apprehension is the most significant impediment to vaccination campaigns being implemented. HCWs' knowledge of the Covid-19 vaccine should be improved in order to increase immunization coverage among HCWs and the general public. Because HCWs are among the first to receive the vaccination, concerns about its safety should be addressed as soon as feasible. Various techniques for increasing vaccine uptake among HCWs should be designed and executed. For complete details visit: Vaibhav Mehta, Dipesh Patel, 2021. COVID-19 vaccine, healthcare workers, Central India. J. Med. P’ceutical Allied. Sci. V 11 - I 1, Pages - 4125 - 4128. doi: 10.55522/jmpas.V11I1.1677.

 A novel series of indole clubbed with pyrimidine was synthesized and evaluated for its in-vitro antimicrobial and antioxidant activities. Among the synthesized compounds, compounds 13, 14, 15, 16 and 19 showed promising antimicrobial activity that comparable to standard drug norfloxacin and fluconazole. Also, for the antioxidant activity, compounds 14 and 16 found to be most active compounds. The active compounds may be utilized as lead for further optimization and rational drug designing. For complete details visit: Sunil Kumar, Ritika, 2022. Synthesis, Antibacterial Activity, Antifungal Activity, Antioxidant activity, Indoles. J. Med. P’ceutical Allied Sci. V 11 – I 1, P- 4119 - 4124. doi: 10.55522/jmpas.V11I1.1566. https://jmpas.com/abstract/855

 With the help of the proposed model with 92.57% prediction accuracy, users can easily detect lung images and classify them as normal or abnormal, helping patients receive treatment in advance. This helps the doctors to give the treatment accordingly to the patient by seeing its severity. The model is not only developed for identifying lung disease but it also can identify the other normal or abnormal images by training their dataset which could possibly affect human organs. The project can be enhanced to classify all possible diseases for all parts of the human body. Implementing this model will provide a better life for people with diseases. Implementing this model makes it easy for users to identify and perform the necessary steps if the disease is mild. Special Thanks This work was supported by Jaswanth Duppala and Eali Stephen Neal Joshua (Department of CSE, Vignan’s Institute of Information Technology, Visakhapatnam, AP, India). For complete details visit: Hye-jin Kim, 2...

 Thus, we observe that there is quite a significant number of undiagnosed cases of OSA in the pre-surgical population of a maxillofacial surgery unit. Based on this study results, we can conclude that there is a strong and significant correlation between risk factors such as snoring, obesity, male gender, excessive daytime sleepiness, hypertension and OSA. Looking at the number of undiagnosed cases of OSA in the pre-surgical population, and the associated peri-operative risks and complications of OSA due to the interactions of sedatives and opioid analgesics used during general anaesthesia, we need an easy, costeffective and universally reproducible screening protocol for OSA screening. For complete details visit: Siddharth desai, Shubha laxmi, Siva Bharani, 2021. Obstructive Sleep Apnea, STOP-BANG questionnaire, Overnight Pulse Oximetry, Oxygen Desaturation Index. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4108 - 4113. doi: 10.55522/jmpas.V11I1.1516. https://jmpas.com/abst...

 Teneligliptin and vildagliptin appear to effective and safe as add-on treatment for T2DM patients inadequately controlled on stable dose of metformin. Teneligliptin is non inferior to vildagliptin in controlling glycemic parameters (FPG, 2Hours PPG, and HbA1c). For complete details visit: Jameel Ahmad, Nida Rizvi, Farida Ahmad, Sheelu Shafiq Siddiqi, 2022. Teneligliptin versus vildagliptin in indian patients with type 2 diabetes inadequately controlled with metformin. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4100- 4104. doi: 10.55522/jmpas.V11I1.1478. https://jmpas.com/abstract/852

 We developed a new methodology for automatic mass detection to aid in the manual identification of masses in mammography images. The suggested project begins by identifying the tumour inside the specified image region of interest using a fuzzy c-means technique, and then verifies the image features (i.e. texture) produced from the FCM input data using the GLCM feature texture to help in the segmentation process. As can be observed, the suggested methodology's results were more closely matched with those from the Mini-MIAS database, demonstrating that the suggested technique is capable of properly and automatically extracting masses from ROI. For complete details visit: Hye-jin Kim, 2022. PSNR, MSE, Malignancy, Cancer, Classification, Fuzzy Means Algorithm. J. Med. P’ceutical Allied Sci. V 11 - I 1, P- 4093 - 4099. doi: 10.55522/jmpas.V11I1.1431. https://jmpas.com/abstract/851

 It has been unequivocally established that chronobiology and chrono pharmacology are symbiotic constituents which affects the human psychological and physiological processes. Shift workers may treat with chronotherapy to get the healthier results. However, the chronotype, life style, and longevity preference of shift workers has not yet been addressed adequately. It is also not known if shift work modulates human personality with special reference to personality traits. Further, issues involving social satisfaction, social disruption and job satisfaction among shift workers and more especially among Indian shift workers are not yet properly evaluated. It is also not known if shift work has any negative effect on human longevity. It is indeed striking that in a country like India, where about 30-40% of its total work force might be working shifts, research in the domain of shift work is yet to develop. For complete details visit: K Venu Achari, 2022. Chronobiology, Biological perio...

Nanoparticles represent an extremely impressive platform-wide variety of applications in the diagnostic and medicinal fields. The size and surface characteristics of these systems can be modulated by using diverse construction materials for individual applications. NPs carrier systems have promising potential to convert poorly soluble and poorly absorbed biologically active substances into drug delivery forms. For complete details visit: Neeta Solanki, 2022. Drug delivery system, Nanoparticles, Bioavailability. J. Med. P’ceutical Allied Sci. V 11 - I 1, P4105 - 4107. DOI: 10.55522/jmpas.V11I1.1494 https://jmpas.com/abstract/921