Journal of Medical Pharmaceutical and Allied Sciences

 In the current examination, it is verified that occupied with drugs change control doesn't mean the completion of any change; it proposes the specific control of changes to guarantee the developments made don't inimically affect the wellbeing, quality, adequacy, or strength of the medicine thing. Changes made in a medicine making plant that can impact the safety, quality, viability, intensity, or nature of a prescription planning should be made in a manner that guarantees these attributes are not antagonistically affected. Thinking about the altogether globalized level of the genuine prescription industry, finishing the change in the design or possibly activity isn't as essential as no vulnerability. With the advances in science and advancement that we have seen all through the long stretch, it is opinioned that a change should be struck to fittingly use the entire of the gadgets accessible to improve ordinary conditions and address clinical issues over the globe. Doubtles...

 This study reports the synthesis of (Z)-N-(5-(benzylidene)- 4-oxo-2-phenylthiazolidin-3-yl)-6-methyl-4-(2-nitrophenyl)-2-oxo1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives and all were characterized by spectral and elemental analysis. The highest antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441, Gram-negative bacterium: Escherichia coli MTCC 443 and fungal strains: Candida albicans MTCC 227 and Aspergillus niger MTCC 281 were shown by compounds PT7, PT10 and PT18 respectively. The anticancer study results demonstrated that (Z)-N-(5-(4-nitrobenzylidene)-4-oxo2-phenylthiazolidin-3-yl)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carboxamide (PT9, IC50 = 12.68 μM) and (Z)-N-(5-(4-(diethylamino)benzylidene)-4-oxo-2-phenylthiazolidin3-yl)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine -5-carboxamide (PT14, IC50 = 15.27 μM) were the most effective anticancer agents. For complete ...

 Upper cross syndrome (UCS) refers to tightness of muscles such as pectoralis major, upper trapezius and levator scapulae and weakness of deep neck flexors, scalene, rhomboids, serratus anterior, middle and lower trapezius. Poor posture is associated with imbalance created in musculoskeletal system and common condition to be reported as upper cross syndrome. It is commonly seen in people with forward head posture, desk job workers, dentist, beauticians etc. The resulting clinical presentation is complaint of pain in neck and shoulder, cervicogenic headache, hunched upper-back and rounded shoulder. Children are not as proactive today and the rate of the UCS is on the rise. This deviated posture and sedentary lifestyle continues, where it progresses more as the age progresses in adulthood. To screen, detect, early treat as well as prevent upper cross syndrome in young individuals. Asymptomatic individual with 20-40 years of age group was explained about the procedure before commencem...

 Short eyes were more prone to greater post-operative ACD changes as compared to long eyes. Assessment of pre-operative ACD and its subsequent changes after cataract surgery may help in predicting post-operative refractive error. The lesser amount of change in ACD may result in a hyperopic shift and a higher amount of change would result in the myopic shift. Conflict of interest-declared none Source of funding-None Ethical clearance-ethical clearance committee approval was obtained before the study. For complete details visit : Prerana Agarwal, Sushma Kumari, Suryadev Tayal, Ankur Gautum, 2022. Evaluation of the role of anterior chamber depth changes in determining refractive outcome after cataract surgery. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4574 - 4577 doi: 10.55522/jmpas.V11I1.2599.

 Even in the short term, Yoga practice is supposed to enhance well-being and counteract psychopathology through modification of emotional reactivity. Yoga teaches that emotional responses may be less pronounced with longer and more frequent practice, potentially when people perform yoga for mental rather than physical reasons. But now the result is negative. We tested 320 yoga practitioners of varying experience (between 6 months and ten years of practice). We assessed participants’ self-reported emotional experience and peripheral physiological reactions, and all too n we can say that yoga does not affect the emotional maturity of the students. We can’t be emotionally stable through yoga practices; yoga affects our nervous system and glandular system, which makes us emotionally mature. So, yoga helps to improve emotional maturity. But not all dimension correlates with yoga, e.g., the result primarily, hence a result may change after less yoga time is (1hr). For complete details vi...

 For patients with TNBC, the most difficult challenge is overcoming the development of medication resistance in these cancers, which can be extremely difficult. Medicines that target the NF-κβ pathway and try to reduce its activity may therefore prove to be among the most effective treatment options in the future. Patients with the triple negative type of this disease, on the other hand, face a very compelling need to overcome resistance to targeted therapy because they have no effective targeted therapeutic choices available to them. In the field of TNBC treatment, it has shown to be highly challenging, a difficulty that has been exacerbated by the development of drug resistance, toxicities associated with chemotherapy and radiotherapy, and the inherent heterogeneity of the tumours themselves. For a subset of people suffering from this illness, blocking the epithelial growth factor receptor can be an effective treatment. As a result, the development of innovative therapeutic targe...

 This case study shows that proper plan for management is very necessary in order to make patient independent following degloving injury. The exercises and mobility improve patient’s quality of life. Physiotherapy treatment protocol was given for about 6 months, patient was again reassessed and then prognosis was made. Now he is able to perform activities of daily living. He is now able to walk.  For complete details visit : Nupur T, Gunjan S, Tejaswini B. F, Pratik P, Neha C, Om C. W, 2022. Essentials of Physiotherapy After Degloving Injury in a 45-year-old Male- A Case report. J. Med. P’ceutical &Allied Sci. V 11 - I 2, Pages – 4560 - 4563. doi: 10.55522/jmpas.V11I2.1246.

 In recent years, the growing demand for and importance of traditional medicine has posed a threat to the survival of some plant species. Biotic and changeable environmental conditions have an impact on traditional plant propagation strategies. In both traditional and contemporary medicine, the importance of S. chirata as a treatment for a variety of illnesses and health issues has been extensively established. Using a variety of contemporary approaches, scientists were able to identify a number of medicinally essential chemicals found in S. chirata, as well as establish a platform for sustaining enough production of this diverse medicinal plant species. As a result, pharmaceutical corporations are attempting to create medicines from therapeutic plants. Swertia chirata is a rare plant that is also one of the most powerful medicinal herbs. It may be used to treat a variety of diseases. There have been no reports of this ethnobotanical herb's toxicity or adverse effects. In order to ...

 From the above research work, it can be concluded that the proposed method is sensitive, specific, and robust, with good delicacy and perfection. The 1st order derivative spectroscopy was developed to analysed the mixture, provide advantage that improved resolution and used to eliminate the spectral interference by broad band discrimination. The major advantage of this technique is that it is developed for synthetic mixture and helpful for experiment to develop for its combined dosage form. So that method can be implemented for quantification of commercially available dosage form by the pharmaceutical industry and analytical laboratories in future. For complete details visit : Ashvin Dudhrejiya, Ashok Patel, Jayant Chavda, Dhruvanshi Gol, Priyal Koli, 2022. Spectrophotometric simultaneous determination of efonidipine hydrochloride ethanolate and telmisartan in synthetic mixture by first order derivative method. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4547 - 4551 d...

 With the rise in incidence of co infections, it’s a need of the hour to study them. Dengue and other co infections may lead to serious clinical complications like multi organ involvement. Studies have reported false positive (cross reactivity) for S. typhi and Dengue viral infection. The treating physicians should be aware of this cross reactivity in endemic and epidemic areas. Further studies and research are needed for understanding the consequences and nature of co infections. Improved knowledge of the factors controlling individual’s risk of co infection and the mechanism of action of the pathogens from further research will help in treatment and diagnosis of concurrent infections. Also, other laboratory parameters, clinical and serological tests with gold standards should always be done for proper and confirmatory diagnosis. For complete details visit : Shruti Vimal, Vidya Vishwanathan, Arpana Dharwadker, 2022. Dengue and typhoid co-infection study. J. Med. P’ceutical Al...

 This study concludes that the Endonasal Cranial Balloon Release technique would reduce the pain and discomfort due to migraines without remissions. It rehabilitates the worker with improved productivity. We also suggest several randomized clinical trials should be conducted to identify the potential benefits of this therapy. For complete details visit : Anjali Agarwal, Suraj Kumar, Gowrishankar Potturi, 2022. Effectiveness of endonasal cranial balloon release technique in relieving symptoms of migraine and improving the quality of work in a sedentary worker-a single case study. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4539 - 4541 doi: 10.55522/jmpas.V11I2.2224.

 Drinking water that is safe to drink is the most essential necessity of any person or other creature. Because if the water is contaminated it can affect our life and health. In this research on song river, it was found that this water is contaminated. There was presence of diseasecausing bacteria Salmonella spp., klebsiella spp., Escherichia coli, Pseudomonas spp., were found and, also faecal coliform was found. Therefore, this water is not suitable to drinking without any purification. Song River water is polluted and contaminated by coliform and faecal coliform bacteria treatment of polluted river water made the water potable by ensuring 100% disinfection of water. It is recommended that purification method like boiled water, UV treated water etc. be used to purify the contaminated water before it can be used for drinking. Monitoring of water is to be done within constant time period. Aware people not to throw garbage of any type in river because this river is also a tribut...

 It this study it can be concluded that combining both the IASTM and Exercises have got beneficial effects in reducing the pain intensity and improving the foot and ankle function in patients with heel pain. The IASTM technique given by using edge mobility tool is proven to be effective in patients with heel pain as very less studies have been carried out on the effects of edge mobility tool. For complete details visit : Shivani K B, Pratik P, Neha C, Om C. W, 2022. A Case report on Efficacy of Instrument Assisted Soft Tissue Mobilization in a patient having heel pain. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages 4531 - 4533. doi: 10.55522/jmpas.V11I2.1242.

 This study documented the xanthine oxidase inhibitory activities, in vitro, of the antioxidants isolated from the stem bark of Jatropha podagrica. The findings showed that M3 (tomentin, fraxetin, methyl gallate) is a potential source of natural antioxidants as well as an anti-gout agent.       In vivo tests are recommended to affirm the bioavailability of M3 for the development of medicines for gout prevention and/or treatment. This will also ascertain the value of this plant for sustainable cultivation by the agricultural sector. For complete details visit : Truong Ngoc Minh, Yusuf Andriana, Bui Quang Minh, Nguyen Quang Trung, Chona de Guzman-Gelani, 2022. Investigation of xanthine oxidase inhibitors in bioactive components of Jatropha podagrica stem bark. J. Med. P’ceutical Allied. Sci. V 11 - I 2, Pages - 4527 - 4530 doi: 10.55522/jmpas.V11I2.2236.

 Liposomal carrier has been optimized for intranasal administration of CS. OCS-NSLs has been developed with the help of the BBD design, which presents an optimized preparation of the best particle size and trapping efficiency. A reasonable drug encapsulation was reported to OCS-NSLs along with a sustained drug release property in a 24 h study period. Thus, OCS-NSLs serve as potential drug delivery vehicles in treating glioblastoma effectively invitro.  ACKNOWLEDGMENT    The author is thankful to JNTUA-OTPRI, Ananthapuramu for providing the laboratory facilities, chemicals to carry out the research work. For complete details visit : M Alagusundaram, K B ChandraSekhar, G Nethra Vani, 2022. Nano-sized Liposomes for nose to brain delivery of Carmustine Formulation, Optimization by Box Behnken design. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4518 – 4526. doi: 10.55522/jmpas.V11I2.2159.

 It’s quite evident now, that it could undoubtedly forge the quality of medical management at community pharmacies, and help it to achieve novel forte. But it’s still a novel concept, it has yet not achieved a state of plateau in terms of evolution/development. Implying it still has an ample scope to be worked upon and result into its better variants. The collusion of IoT network architecture with Community Pharmacy, would unquestionably help us to help us to come across varying hindrances. As the Community Pharmacies have a plethora of records and data to be managed. At this point the involvement of IoT could really streamline their workflow and assist them with a better operational ability. The collusion of IoT in community pharmacy would really bear great outcomes, but before their collusion it must be foreseen that whether their contemporary SOPs would go hand in hand along with the application of IoT network architecture or not. For complete details visit : Pargaien A V, ...

 As she is a child an early operative procedure was done after diagnosing. Early surgery will help for better rehabilitative process and she will be able to achieve all the milestones in adulthood. This surgery may not bother in her instrumental activities of daily living in later life. Healing process is fast and it will achieve a higher recovery rate.  List of abbreviation :UAS-Upper abdominal surgery PPCs-Post operative pulmonary complications For complete details visit : Gunjan S, Ruchika, Tejaswini B F, Shruti D, Neha C, 2022. Impact of Comprehensive Rehabilitation in an 11-year-old patient undergone exploratory laparotomy in right ovarian mass. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4507 - 4510. doi: 10.55522/jmpas.V11I2.1241

 Infectious diseases can be avoided by practicing good hygiene, avoiding the source of contact, using a mask when cleaning dusty areas, getting vaccinated, and providing a safe and healthy environment in a child care facility. These actions can have a significant impact on the health and well-being of millions of children.  ACKNOWLEDGMENT  We would like to acknowledge the Department of Pharmacy Practice, JSS College of Pharmacy, Ooty for their support. For complete details visit : K Sumathi, William Delphin Bencer, Chandrasekar Keerthana, 2022. A review on common infectious disease conditions and antibiotic resistance in pediatric population. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4503 - 4506 doi: 10.55522/jmpas.V11I2.1451.

 A series of novel Pyrimidine derivatives (H1–H20) were synthesized and evaluated for its antimicrobial and anticancer potential. In general, some synthesized compounds were found to be good antimicrobial and anticancer agents. Anticancer screening results indicated that compound 10 (LC50 =0.09 µMolar) was the most active anticancer agent as compared to standard drug Adriamycin (Doxorubicin) ((LC50 =0.005 µMolar). Antimicrobial activity results indicated that compound 4 was the most active antimicrobial agent and may serve as important lead for the discovery of novel antimicrobial agents. For complete details visit : Mohan Verma, Prabhakar Kumar Verma, 2022. Synthesis, characterization, antimicrobial and anticancer evaluation of (e)- n'-benzylidene-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carbohydrazide derivatives. J. Med. P’ceutical Allied Sci. V 11 - I 2, Pages - 4498 - 4502 doi: 10.55522/jmpas.V11I2.2190.

 A series of novel Pyrimidine derivatives (H1–H20) were synthesized and evaluated for its antimicrobial and anticancer potential. In general, some synthesized compounds were found to be good antimicrobial and anticancer agents. Anticancer screening results indicated that compound 10 (LC50 =0.09 µMolar) was the most active anticancer agent as compared to standard drug Adriamycin (Doxorubicin) ((LC50 =0.005 µMolar). Antimicrobial activity results indicated that compound 4 was the most active antimicrobial agent and may serve as important lead for the discovery of novel antimicrobial agents. For complete details visit : Mohan Verma, Prabhakar Kumar Verma*. Synthesis, characterization, antimicrobial and anticancer evaluation of (E)-N'-benzylidene-6-methyl-4-(2- nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide derivatives, Journal of medical pharmaceutical and allied sciences, Volume 11 – Issue 2, 2190, March – April 2022, Page – 4498 - 4502.

 Prenatal care was affected by the pandemic since the proposed goal was not achieved and showed lower than the period without pandemic as we present, pregnant women attended 86.6% in pandemic and 114.8% without pandemic, pregnant women with first control in the first trimester 58.3% and 55.6%, pregnant women with six controls 62.1% and 88.9%; pregnant women with six controls with complete set 44.8% and 88.9 without pandemic. The monitoring of pregnant women was strengthened during the pandemic by increasing the number of visits and telephone follow-up. During the pandemic, there were 1.8 visits to each pregnant woman and 3.9 telephone follow-ups, compared to 0.8 visits per pregnant woman, which means that there were pregnant women who were not visited during the pandemic. Delivery care reached 236.7%, a phenomenon that occurred due to the return of the population and to deliveries from other jurisdictions; 5% of deliveries occurred at home, compared to 86.8% and 0% outside the pand...

 The review concluded that there is a need to improve HRQoL among patients diagnosed with rheumatoid arthritis to decrease the rates of treatment failure and improve treatment response. Patient care should be focused on behavioral and life style modification along with symptomatic relief by pharmacological treatment provided to such patients at both acute and chronic phase of disease. There is a need to conduct future studies to explore effect of different strategies used for treatment of rheumatoid arthritis. Longitudinal studies can be proposed to explore the factors affecting HRQoL among such patients and treatment failures. Moreover, effects of non-pharmacological treatment on HRQoL can be investigated. For complete details visit : Madeeha Malik*, Azhar Hussain, Ayisha Hashmi, Faiqa Zainab Awan. THE IMPACT OF RHEUMATOID ARTHRITIS ON HEALTH RELATED QUALITY OF LIFE: A LITERATURE REVIEW OF DEVELOPED AND DEVELOPING WORLD, Journal of Medical Pharmaceutical and Allied Sciences, ...

 Euphorbia thymifolia linn (euphorbiaceae) it is an annual herb pan-tropic distribution. This is mainly found in waste land and along roadside wall sides under humid condition. Whole plant contains a crystalline alkaloidal principal allied to quercetin, 5,7,4-trihydroxy flavones 7-glucoside and essential oil. The plant is a rich source of phytochemicals like tannin, flavanoid, phytosterol, quercetin through lacking substantial phyto pharmacological studies. Euphorbia thymifolia total steroid EETS at dose 75 mg/kg showed a significant increase (p≥0.001) in sleeping time, depression of locomotor activity duration of tail suspension induced immobility (p≤0.01). Euphorbia thymifolia total phytosterol showed marked CNS depressant and sub-maximal, muscle relaxant activity and anxiolytic effect. For complete details visit :  Brijesh Sirohi*, Vishnu Raj, Amit Pandey. QUALITATIVE AND QUANTITATIVE ESTIMATION OF EUPHORBIA THYMIFOLIA LINN, Journal of Medical Pharmaceutical and Allied Scie...

 Due to global alarm against side effects caused by allopathic drugs there is trend of returning back to nature. Large number of herbal species has been traditionally or as folk medicines [21] against inflammatory disorders. The current research is to explore the usage of Garcinia cambogia fruit against arthritis and inflammation experimentally representing significant activity. Hence Garcinia cambogia fruit can be used as a potent natural anti-arthritic activity and antiinflammatory agent. The anti-arthritic and anti-inflammatory activity might be due to xanthones present as one of the secondary metabolite. Further isolation of xanthone is necessary to ascertain mechanism behind Anti-arthritis activity and anti-inflammatory activity. The exploration is based on the need for antiarthritis and anti-inflammatory agents from natural herbal sources with potent activity and fewer side effects. The source of new Anti-arthritis and Anti-inflammatory drugs from herbal medicine is a fr...

 In recent years, interest has increased in the utilization of therapeutic plants since herbal remedies have been publicized to be safe and without adverse side reaction as synthetic drugs. The goal of this research was to perform qualitative and quantitative phytochemical evaluation and also to examine the mineral contents of Annona muricata leaf collected in Ilorin, Kwara State, Nigeria. Annona muricata leaf was dried at room temperature. Cold extraction method was employed to obtained crude extracts with solvents of varying polarities. Hexane, ethyl acetate and ethanol were utilized. Mineral determination was carried out using Atomic Absorption Spectroscopy. Phytochemicals from the leaf extracts were; saponins, phenols, tannins, glycosides, steroids, terpenoids and alkaloids. All the samples showed high content of alkaloids and saponins. Mineral evaluation of the leaf showed that Calcium had highest concentration in the leaf, (6.7 mg/g) while Iron, Manganese, Copper and Zinc wer...

 We describe the case of a 10-year-old girl admitted to a paediatric department with the clinical diagnosis of Henoch-Schonlein purpura (HSP). Symptoms on admission included a petechial rash on the lower limbs, abdominal pain, vomiting and loose motions with mucus. Abdominal pain and sigmoidoscopy suggested edematous bowel loops in left illiac fossa. The severity of cardiac, gastrointestinal, renal and skin involvement made the initial diagnosis of HSP For complete details visit :  M. Kalyan Sai, L. Reddenna*, M. Bhavani, J. T. Rudra, T. Rajavardhana, E. Pavan Kumar, T. Usha Nandini, V. Sreedhar. HENOCH-SCHONLEIN PURPURA ASSOCIATED WITH ACUTE WATERY DIARRHOEA, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 1, 799. January 2019, 2067-2068.

 The present study aims at implementation of Doctor of pharmacy services in identification reporting of drug related problems in in-patient units of cardiology and pulmonary medicine departments of an ESI hospital with an objectives of identification and reporting drug related problems. It is a prospective observational study& conducted for a period of six months from October 2018 to March 2019. The Patients admitted in hospital was 169 Patients. All the required data was collected from patients through personal interview and case sheets and treatment charts and data collection forms. All the patients satisfying the inclusion criteria above 18 who are willing to participate in this study were selected and exclusion criteria patients who are not willing to participate in this study like pregnancy lactation and cancer patients were excluded. A total of 169 patients were selected for the study, in which the total number of 180 drug related problem overcome by doctor of pharmacy du...

 The present study concludes that in India there is no proper awareness on Breast Cancer, Cervical Cancer and PCOD SelfTest & prevention among Women. Hence this study clearly states that role and importance of Doctor Of Pharmacy health care professionals in educating women in India and in detection of breast cancer, cervical cancers ,PCOD at early of their stages & prevention. The main aim and motto of the present study is achievement of healthy women India. We hope we achieved some extent by conducting this study by creating awareness among some Indian women as part of our responsible health care professional, and hope this study will be useful for further generations too. For complete details visit :  Dr. M.manasa rekha* . Karuna sharma, Rinku mathappan, k. Rekha. A PROSPECTIVE STUDY ON ROLE OF DOCTOR OF PHARMACY IN ESTIMATING THE KAP (knowledge, attitude, practice) OF SELF TEST FOR PCOD, BREAST AND CERVICAL CANCERS AND CREATION OF AWARENESS AND PREVENTION AMONG WOME...

 In India there is imbalance between physician and patient ratio recent statistics states that for every 1000 patients only one physician is available in India in this situation there is increased work load on physician ultimately leads to therapeutic failure as the physician even don’t have enough time to look over therapeutic and drug related issues, The present study clearly states and concludes that there is urgent need in creation of active role Doctor of Pharmacy Profession in Indian health care system for providing better therapy, positive health related outcomes and rational usage of drugs. For complete details visit :  Patel Aneesh Kumar, Dr. Omray Lavakesh, Soni Pushpendra. A PROSPECTIVE STUDY ON IMPLEMENTATION OF DOCTOR OF PHARMACY/CLINICAL PHARMACY SERVICES TO GENERAL MEDICINE DEPARTMENT OF AN ESI HOSPITAL, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 2, 808. March 2019, 2119-2132.

 Agenesis of the corpus callosum is a congenital disorder in which there is a whole or fractional absence of the corpus callosum. Some characteristics with callosal disorders include vision impairments, poor motor coordination, hypotonia, delays in motor milestones such as sitting and walking, delayed toilet training, low perception of pain, and chewing and swallowing difficulties. Sometimes associated with callosal disorders include spasticity, seizures, early feeding difficulties and/or gastric reflux, hearing impairments, abnormal head and facial features, and a mental handicap. For complete details visit :  Y. Yamini, L. Reddenna*, M. Bhavani, J. T. Rudra, T. Rajavardhana, CORPUS CALLOSAL AGENESIS WITH CENTRAL PONTINE MYELINOLYSIS: A RARE CASE , Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 2, 800. March 2019, 2112-2118.

 The study revealed that important phytochemicals abound in the seed of Annona muricta. It is also a rich source of vital minerals, fat and fiber. These components could be utilized to enhance health and prevent diseases. It is recommended that the seed of Annona muricta could be used in feed formulation as well as other industrial purposes. For complete details visit : Nwaehujor Idorenyin Ugochi*, Ayanda Ifedapo Solomon, Lawal Israel Oluwasanmi. PHYTOCHEMICAL ANALYSIS, PROXIMATE COMPOSITION AND MINERAL CONTENTS OF THE SEED OF ANNONA MURICATA, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 2, 806. March 2019, 2105-2112.

 The triptan class of the drugs mainly prescribed into the treatment of migraine such Sumatriptan succinate (SUM). Its IUPAC name is 3-[2- (Dimethylamino) ethyl] –N-methyl-1H indole - 5- methane sulphonamide succinate. SUM shows the agonistic activity on 5HT1D and 5- hydroxy tryptamine receptors and its subtypes. The SUM undergoes the biotransformation through the monoanino oxidase-A. It is used in the treatment of acute migraine relief or its attacks. Zingiber officinale i.e. Ginger belongs to family- Zingiberaceae. Ginger find in many of regions of India widely use in spice in many of countries condiment to add flavor to food. Ginger consisting two of categories herbal medicines of substances such as volatile and non-volatile constituents mainly in its rhizomes. Active ingredients is sesquiterpene, monoterpenoid hydrocarbons also gingerols, shogaols, paradols, and zingerone. Its shows the good antiinflammatory result. For complete details visit :  Sonawane Harshali R*, Dr. S...

 It is clear from this study that, the leaves, stems, roots and flowers of Nicotiana tabacum (both fresh and dried) have useful phytochemical properties which are responsible for its antibacterial activity. The antibacterial activity of this plant can be described as broad spectrum having inhibited both Gram negative bacteria (Escherichia coli) and Gram positive bacteria (Staphylococcus aureus). Thus, the plant can be used as an alternative source for production of chemotherapeutic agent especially against Escherichia coli and Staphylococcus aureus. The minimum bactericidal concentration (MBC) can further be determined. For complete details visit :  TYOKUSA A. G.*, ISHOMKEGH S. A., ITOLO O. TOBACCO PLANT (Nicotiana tabacum L) CRUDE EXTRACT AND ITS ANTIBACTERIAL ACTIVITY ON ESCHERICHIA coli AND STAPHYLOCOCCUS AUREUS, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 2, 814. March 2019, 2088-2098.

 Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Herbal formulation shares growing demand in the world market. it is very good attempt to establish the herbal hydrogel containing aqueous extracts of Neem oil , aloe vera, rosewater. The plants have been reported in literature having antimicrobial, antifungal, antiseptic, moisturizing, soothing effects and quite effective aganist to acne. Formulation are prepared by using varied concentration of extract prepared formulation (f1 to f8) where evaluated for various parameters like colour, appearance, consistency, washability, pH and spreadability, extrudability, skin irritation. For complete details visit :  Dr. CH Ajay Babu, Dr. M Prasada Rao, N Anitha*, S Bhargavi Latha, CH Lakshmi Anusha, K Parishudda, S Pragathi. DESIGN AND CHARACTERIZATION OF HYDROGEL FORMULATIONS CONTAINING ALOE VERA AND NEEM SEED OIL, Journal of Medical Pharmaceutical and Allied Sciences...

 Reflex epilepsy is an unusual form of epilepsy with varying triggers. The present case reports hot water epilepsy in a 17-year-old adolescent. This type of epilepsy may occur in infants, adults and pregnant women. Video-EEG and EEG-fMRI can be utilized for the diagnosis of these seizures. Clobazam is the drug of choice for HWE; depending upon the disease severity, benzodiazepines may also be considered. Avoidance of hot water is the cornerstone of the treatment being offered in this type of epilepsy. A combination of clinical and geographic studies may be helpful in knowing the prognosis of this rare type of epilepsy. Furthermore, since the exact pathophysiology of the epileptic phenomenon in the brain is unclear, further research in this area may advance the existing pieces of literature. For complete details visit :  Pathan Amanulla Khan1 , Neda Fatima2 , Naureen Fatima1 , Juwerriah Nishaat1, HOT WATER EPILEPSY: A CASE REPORT AND LITERATURE REVIEW,Journal of Medical Pharmac...

 The study concluded that the improved knowledge and attitude clearly indicates the benefits of pharmacist-provided Patient counselling. The pharmacist is in a highly noticeable and accessible position to answer patient concerns and queries about their drugs, disease and lifestyle. It is important for clinical pharmacists to provide appropriate, understandable and correct information and answers to patients about their drugs and lifestyle changes. Patient counselling by the clinical pharmacist plays an important role in incorporating education to the diabetic patients. We conclude that pharmacist provided patient counseling is a useful tool for decision-making in planning and monitoring disease and is a part of management of Diabetes. For complete details visit : Agilesh N V*, Anju Mariya Joy, Deepak P, Rahul M. AN OBSERVATIONAL STUDY ON EVALUATING THE IMPACT OF PATIENT COUNSELLING IN ENHANCING THE KNOWLEDGE, ATTITUDE, PRACTICE AND QUALITY OF LIFE AMONG DIABETES PATIENTS, Journal o...

 The suitable chromatographic methods (RPHPLC, HPTLC) were developed and validated for estimating OND and PAN in tablet dosage form. HPLC method was stability indicating as it achieved separation of both drugs from potential degraded products. More degradation has been observed for either of drugs in combination than degradation of such single drug. For complete details visit :  Patel Nitya*, Dr. Omray Lavakesh, Mr. Soni Pushpendra. STABILITY INDICATIµG ASSAY METHOD DEVELOPMENT AND VALIDATION FOR ONDANSETRON HYDROCHLORIDE AND PANTOPRAZOLE SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORM, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 4, 851. JULY 2019, 2308-2315.

 Indian drug market is flooded with various drug formulations, the majority of which are proprietary multi-drug combinations. Patients are being made to ingest totally unnecessary drugs. One of the major principles of rational use of drugs is to prescribe only those drugs that are really indicated; unnecessary drugs should not be prescribed and thus will improve the quality and cost of treatment. For complete details visit : Pradnya Deolekar, Pramila Yadav, Sandesh Deolekar, Prathmesh S. Deolekar . ANALYSIS OF HAEMATINIC PREPARATIONS AVAILABLE IN INDIAN MARKET, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 4, 847. JULY 2019, 2300-2307.  

 A Drug utilization study is considered to be one of the most effective methods to assess and evaluate the prescribing attitude of physician and help to promote rational use of drugs. The prescription ratio of Insulin injection and oral hypoglycemic agents was rational. The findings of the study suggest the need to increase the awareness of generic prescribing and prescribe from National list of Essential Medicines (NLEM). This study showed that slightly half 67.3% (n=37) of diabetic patients had good individual knowledge of their anti- diabetic medication. It was also observed that 50.9% (n=28) and 27.3% (n=15) of the participants had average and poor individual knowledge respectively (Table 3). Patients’ knowledge of anti-diabetic medication in this study comprised of five components that is being able to provide the drug name, drug administration and purpose of medication, storage of medication and dose of prescribed medication. Metformin and sulphonyl ureas have same glyce...

 Legitimate accumulation and isolation of biomedical waste are significant. There isn't sufficient data on medicinal waste administration advancements and its effect on general wellbeing and condition. Routine with regards to legitimate therapeutic waste transfer and the board is additionally lacking. In any case, there is requirement for bringing issues to light about medicinal waste and its related issues. Far reaching investigation of current waste administration rehearses in both government and private medical clinics. Course of action of appropriate preparing projects of medical clinic staff and healthcare experts. Checking and assessment of medical clinic squander the board mediations. For complete details visit :  Thakre Anup R*, Durge Rohit T, Shah Sapan K, Chaple Dinesh R. HOSPITAL WASTE MANAGEMENT: A REVIEW, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 4, 844. JULY 2019, 2256-2275.

 In conclusion, it could be said that the hydroalcoholic extract of S. virginianum exhibited a significant hypolipidemic activity. Administration of HFD produced a highly significant increase in weight mesenteric fat pads. A reduction in the raised weight in the fat pads as observed in the groups of animals treated with hydroalcoholic extract of S. virginianum may be attributed to increased thermogenesis and decreased lipogenesis. For complete details visit : Suraj Sahu, Narendra Patel, Hemant Kumar Sharma, Prabhakar Budholiya, Prabhat Kumar Jain. STUDY OF ANTIHYPERLIPIDEMIC EFFECT OF HYDROALCOHOLIC EXTRACT OF SOLANUM VIRGINIANUM WHOLE PLANT IN HIGH FAT DIET FED RATS, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 5, 861. September 2019, 2359-2366.

 Thus from the whole research work it can be concluded that, the oral fast dissolving tablet of PRE were formulated and evaluated for various parameters. From the compatibility studies by IR of drug it was found to be compatible with other formulation excipients. All evaluation parameter were within specification. The Croscarmellose sodium shown faster drug release than sodium starch glycolate and Crospovidone. Formulation F4 release maximum drug within the 10mins.ie. 98.21 % and shown minimum disintegration time i.e. 45sec than other formulation and hence considered best formulation. For complete details visit : Jitendra Singh, Neelesh Choubey , Hemant Kumar Sharma, Prabhakar Budholiya , Geeta Parkhe. FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF PREGABALIN, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 5, 860. September 2019, 2347-2358.  

 The participants believed that promotion of physical activity was important, but lack of time and motivation were the main barriers to physical activity. The participants expressed their knowledge on the issue that physical activity is important in the prevention of conditions like arthritis, depression, diabetes, heart disease, hypertension, cholesterol, back pain, obesity and osteoporosis. Almost half of the no. of participants occasionally participated in physical activities thereby indicating a positive attitude towards physical activity; however the other half of the participants who do not take part, still have knowledge of the benefits of physical activity in their life. This means that difference lies between being aware and actually performing physical activity. Thus there is need to encourage and motivate people to ensure good public health and prevention of noncommunicable diseases. For complete details visit :  Shaurya Deep Bajwa, Sarvesh Bassi. SURVEY ON AWARENES...

 This study reveals that Kashloff Syrup (Antitussive poly-herbal formulation) does not have any toxic effect at dose of 2000 mg/kg. So No-Observed-Adverse-EffectLevel (NOAEL) of Kashloff Syrup is 2000 mg/kg. The significant decrease in cough bouts proves potential anti tussive activity of Kashloff Syrup (Antitussive poly-herbal formulation). For complete details visit :  Nilesh Patel , Dr Janmejay Patel  , Achal Patel  , Dr Upendra U Zala. ACUTE ORAL TOXICITY AND ANTI TUSSIVE EFFECT OF KASHLOFF SYRUP (POLY HERBAL FORMULATION) ON SO2 INDUCED COUGH MODEL, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 5, 865. September 2019, 2333-2337.

 Exacerbation of Psoriasis by Metoprolol (Beta-Blocker) is a rare incidence and the immediate solution to such incidence would be substitution of Metoprolol with other Antihypertensive drugs. In this article we report a case of Metoprolol induced Exacerbation of Psoriasis. It is very important for health care practitioners to collect all relevant patient information before commencing therapy. A clinical pharmacist plays a major role in collection of patient history and individualisingtreatment accordingly. Critical evaluation of patient history by a Clinical Pharmacist may help in preventing the occurrence of such incidents in future.  For complete details visit :   Anju Mariya Joy, Agilesh N V .  A CASE REPORT ON METOPROLOL INDUCED PSORIASIS, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 5, 857. August - September 2019, 2329-2332 .

 The current study aimed at determining the knowledge level of Pre-hospital emergency care providers about the symptoms of acute stroke and transfer of patients to Ahvaz Golestan Hospital, as a referral center for stroke in Southwest Iran. The current descriptive-analytical study was performed on 144 Pre-hospital emergency care providers of Ahvaz selected using convenience random sampling from April 2018 to March 2019. Required information was collected by a 17-item researcher-made questionnaire. According to the mean score of each domain, the highest and lowest knowledge levels of the participants were in facilities required for the timely transfer of patients with stroke and stroke certified centers, respectively. Also, the overall knowledge of Pre-hospital emergency care providers was at desirable level (mean±SD= 68.35±13.38). The knowledge level of Pre-hospital emergency care providers in the five studied domains was above 65% (mean±SD= 68.35±13.38). Therefore, it is recommende...

 Solubility if drug is one of the important factors that governs the formulation development particularly for the rate and extent of drug to be absorbed. The Techniques discussed above are capable of improving the solubility of drug. These techniques along or in combination can be used to enhance the solubility of drug and thereby bioavailability. Proper selection of solubility enhancement method is the key to ensure the goals of good formulation. For complete details visit :  Manoj Gajanan Bajait*, Roshan Ghatmale, Bhagyashree mundhe. IMPORTANCE OF SOLUBILITY AND SOLUBILITY ENHANCEMENT TECHNIQUES, Journal of Medical Pharmaceutical and Allied Sciences, V 8-I 6, 878. November 2019, 2403-2416.

 With very few exceptions the generic formulations are generally cheaper than brand and present study results showed that there is no significant pharmaceutical difference between them.  2. The patient with chronic disease is in trouble due to long-time heavy prescription cost containing branded drugs. The present study indicates that the generic the drug is cheaper in cost and equivalent with branded drug hence reduce the cost of prescription even OTC and increases patient survival. Hence, considering the above pharmaceutical similarity and per capita income of the people generic drugs are a good choice instead of a branded one.  4. Present the study demonstrates pharmaceutical similarity, bioavailability and other evaluation parameters need to study for future prospect. For complete details visit :  Manoj Gajanan Bajait, Roshan Ghatmale, Bhagyashree mundhey. COMPARATIVE PHARMACEUTICAL STUDY OF SOME BRANDED AND GENERIC TABLET FORMULATIONS, Journal of Medical Pharmac...

 In the present work, it can be concluded that the TRZ floating tablets can be an innovative and promising approach for the delivery of TRZ. The optimized formulation F9 contains HPMC K15, K4 and a gas generating agent. The optimized formulation F9 showed drug release of 97.98% within 12h. The In vitro drug release data of the optimized formulation was subjected to goodness of fit test by linear regression analysis according to zero order, first order kinetic equation, higuchi’s, and korsmeyer’s models in order to determine the mechanism of drug release. When the regression coefficient values of were compared, it was observed that ‘r’ values of first order was maximum i.e. 0.996hence indicating drug release from formulations was found to follow first order release kinetics For complete details visit :  Vivek Jain , Halki Kushwah , Anwar Iqbal Khan, Geeta Parkhe. FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF TRAZODONE HYDROCHLORIDE, Journal of Me...